SPECifIC

Sub-Pathway Extractor and Enricher

Select a disease

Choose one or more nodes of interest. If no nodes are chosen an automated selection procedure will be used.

Subpathways max p-value

Annotation max p-value

Advanced options...

Pathways Max p-value

NoIs max p-value

Nodes max p-value

Min number of nodes

Backward visit

In the era of network medicine, pathway perturbation analysis methods play a central role in the prediction of phenotype from high throughput experiments. SPECifIC is a network-based systems biology tool capable of extracting disease-perturbed subpathways within pathway networks in connection with expression data.

Our system extends pathways with missing regulatory elements, such as microRNAs, and their interactions with genes. The framework enables the extraction, visualization, and analysis of statistically significant disease-specific subpathways computed on a meta-pathway.