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DB08764 - 4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE


Identification
Name 4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE
Accession Number DB08764
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 475.354
Groups experimental
Monoisotopic Weight 474.106666884
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Proto-oncogene tyrosine-protein kinase receptor ret
Name Proto-oncogene tyrosine-protein kinase receptor ret
Gene Name RET
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5782

Predictions


Id Partner name Gene Name Score
2599 Tyrosine-protein kinase HCK HCK 0.1448
407 Vascular endothelial growth factor receptor 2 KDR 0.0691
1144 Hepatocyte growth factor receptor MET 0.0485
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0323
504 Mast/stem cell growth factor receptor KIT 0.0284
4512 Cytochrome P450 3A4 CYP3A4 0.0278
4757 Cytochrome P450 2C9 CYP2C9 0.0269
5787 Angiopoietin-1 receptor TEK 0.0258
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0239
165 FL cytokine receptor FLT3 0.0235
823 Fibroblast growth factor receptor 2 FGFR2 0.023
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0219
26 Vascular endothelial growth factor receptor 3 FLT4 0.021
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0205
32 Vascular endothelial growth factor receptor 1 FLT1 0.0204
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0188
228 Beta platelet-derived growth factor receptor PDGFRB 0.0184
2216 Fibroblast growth factor receptor 4 FGFR4 0.0164
5798 Mitogen-activated protein kinase 11 MAPK11 0.0162
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.016
3856 Fibroblast growth factor receptor 3 FGFR3 0.015
6824 Tyrosine-protein kinase Lyn LYN 0.0146
4924 Cytochrome P450 2C8 CYP2C8 0.0134
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0127
1588 Multidrug resistance protein 1 ABCB1 0.0123
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0119
936 Ephrin type-A receptor 2 EPHA2 0.0114
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0107
1618 High affinity nerve growth factor receptor NTRK1 0.0105
4118 Cytochrome P450 3A5 CYP3A5 0.0092
6030 Cytochrome P450 2B6 CYP2B6 0.0092
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0085
4119 Cytochrome P450 2D6 CYP2D6 0.0083
6016 Cytochrome P450 2C19 CYP2C19 0.008
776 Bile salt export pump ABCB11 0.0069
2164 Multidrug resistance-associated protein 4 ABCC4 0.0056
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.005
6107 Cytochrome P450 3A7 CYP3A7 0.0044
4200 Cytochrome P450 1A2 CYP1A2 0.0039
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