DB08626 - Thiorphan
| Identification | |
|---|---|
| Name | Thiorphan |
| Accession Number | DB08626 (DB01654) |
| Type | small molecule |
| Description | A potent inhibitor of membrane metalloendopeptidase (enkephalinase). Thiorphan potentiates morphine-induced analgesia and attenuates naloxone-precipitated withdrawal symptoms. |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 253.317 |
| Groups | experimental |
| Monoisotopic Weight | 253.077264041 |
| Pharmacology | |
| Indication | Not Available |
| Mechanism of action | Not Available |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms | Not Available |
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Neprilysin | |
|---|---|
| Name | Neprilysin |
| Gene Name | MME |
| Pharmacological action | unknown |
| Actions | inhibitor |
| References |
|
| DTHybrid score | 1.3319 |
Predictions
| Id | Partner name | Gene Name | Score |
|---|---|---|---|
| 957 | Glucagon-like peptide 1 receptor | GLP1R | 0.0863 |
| 3060 | Leukotriene A-4 hydrolase | LTA4H | 0.0863 |
| 244 | Angiotensin-converting enzyme | ACE | 0.0679 |
| 6285 | Thermolysin | npr | 0.0648 |
| 2457 | Bacillolysin | nprS | 0.0635 |
| 952 | Dipeptidyl peptidase 4 | DPP4 | 0.0461 |