DT-Web

DB08597 - 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine


Identification
Name 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Accession Number DB08597
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 399.4882
Groups experimental
Monoisotopic Weight 399.205910447
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Activin receptor type-1
Name Activin receptor type-1
Gene Name ACVR1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5109
FK506-binding protein 1A
Name FK506-binding protein 1A
Gene Name FKBP1A
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4876

Predictions


Id Partner name Gene Name Score
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0493
4148 Serine/threonine-protein kinase mTOR MTOR 0.0491
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.025
733 Activin receptor type 1B ACVR1B 0.024
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0235
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0234
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0234
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0234
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0234
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0234
825 Arsenical pump-driving ATPase ASNA1 0.0234
3435 Arsenical pump-driving ATPase arsA 0.0234
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0234
154 AFG3-like protein 2 AFG3L2 0.0234
395 ALK tyrosine kinase receptor Not Available 0.0234
340 Apoptotic protease-activating factor 1 APAF1 0.0227
4512 Cytochrome P450 3A4 CYP3A4 0.0211
849 Activated CDC42 kinase 1 TNK2 0.0203
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0198
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0198
297 Adenylate cyclase type 1 ADCY1 0.0198
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0198
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0186
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0179
484 Tyrosine-protein kinase ABL2 ABL2 0.0174
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0171
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0169
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0162
1588 Multidrug resistance protein 1 ABCB1 0.0161
6021 Adenosine kinase ADK 0.0158
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0157
661 ADP/ATP translocase 1 SLC25A4 0.0156
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0154
740 Argininosuccinate synthase ASS1 0.0141
865 Argininosuccinate synthase ASS1 0.0141
2680 Argininosuccinate synthase argG 0.0141
3194 Argininosuccinate synthase argG 0.0141
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0133
1525 Heparin-binding growth factor 2 FGF2 0.0118
6107 Cytochrome P450 3A7 CYP3A7 0.0112
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0111
4118 Cytochrome P450 3A5 CYP3A5 0.0108
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0094
776 Bile salt export pump ABCB11 0.0093
1181 Alpha-1-acid glycoprotein 1 ORM1 0.008
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0079
587 Serum albumin ALB 0.0075
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0066
394 Calcineurin subunit B isoform 1 PPP3R1 0.0039
6743 Non-fluorescent flavoprotein luxF 0.0039
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0039
6753 Apolipoprotein M APOM 0.0039
6742 Recoverin RCVRN 0.0039
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0039
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0039
2528 Fatty acid metabolism regulator protein fadR 0.0039
6740 Fatty acid metabolism regulator protein fadR 0.0039
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0039
6747 Chalcone/stilbene synthase family protein MT1417 0.0039
6751 Gag polyprotein gag 0.0039
6749 Polyprotein Not Available 0.0039
6527 Lymphocyte antigen 96 LY96 0.0034
5961 Insulin INS 0.0034
6755 Poliovirus receptor PVR 0.0034
6750 ADP-ribosylation factor 6 ARF6 0.0031
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0031
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0031
6524 Protein tonB tonB 0.0031
2616 Ganglioside GM2 activator GM2A 0.003
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0028
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0028
4210 Toll-like receptor 4 TLR4 0.0028
6316 ADP-ribosylation factor 1 ARF1 0.0027
2297 Genome polyprotein Not Available 0.0026
2322 Genome polyprotein Not Available 0.0026
2694 Genome polyprotein Not Available 0.0026
2719 Genome polyprotein Not Available 0.0026
2860 Genome polyprotein Not Available 0.0026
2928 Genome polyprotein Not Available 0.0026
3160 Genome polyprotein Not Available 0.0026
3260 Genome polyprotein Not Available 0.0026
4783 Genome polyprotein Not Available 0.0026
5726 Genome polyprotein Not Available 0.0026
5779 Genome polyprotein Not Available 0.0026
5867 Genome polyprotein Not Available 0.0026
6253 Genome polyprotein Not Available 0.0026
6301 Genome polyprotein Not Available 0.0026
6380 Genome polyprotein Not Available 0.0026
6381 Genome polyprotein Not Available 0.0026
6437 Genome polyprotein Not Available 0.0026
6520 Genome polyprotein Not Available 0.0026
6521 Genome polyprotein Not Available 0.0026
6652 Genome polyprotein Not Available 0.0026
6734 Genome polyprotein Not Available 0.0026
6735 Genome polyprotein Not Available 0.0026
6736 Genome polyprotein Not Available 0.0026
6737 Genome polyprotein Not Available 0.0026
6738 Genome polyprotein Not Available 0.0026
6739 Genome polyprotein Not Available 0.0026
6744 Genome polyprotein Not Available 0.0026
6748 Genome polyprotein Not Available 0.0026
6894 Genome polyprotein Not Available 0.0026
6898 Genome polyprotein Not Available 0.0026
864 Gag-Pol polyprotein gag-pol 0.0025
2237 Gag-Pol polyprotein gag-pol 0.0025
2326 Gag-Pol polyprotein gag-pol 0.0025
2451 Gag-Pol polyprotein gag-pol 0.0025
2901 Gag-Pol polyprotein gag-pol 0.0025
3165 Gag-Pol polyprotein gag-pol 0.0025
3722 Gag-Pol polyprotein gag-pol 0.0025
6306 Gag-Pol polyprotein gag-pol 0.0025
6624 Gag-Pol polyprotein gag-pol 0.0025
6085 Fatty acid-binding protein, intestinal FABP2 0.0023
2427 Ferrichrome-iron receptor fhuA 0.0022
6228 Nuclear receptor coactivator 1 NCOA1 0.0021
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.002
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0018
465 Calmodulin CALM1 0.0017
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