DT-Web

DB08402 - 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID


Identification
Name 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
Accession Number DB08402
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 404.204
Groups experimental
Monoisotopic Weight 403.012661269
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Peroxisome proliferator-activated receptor gamma
Name Peroxisome proliferator-activated receptor gamma
Gene Name PPARG
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0225
Nuclear receptor coactivator 2
Name Nuclear receptor coactivator 2
Gene Name NCOA2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0089
Retinoic acid receptor RXR-alpha
Name Retinoic acid receptor RXR-alpha
Gene Name RXRA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4886

Predictions


Id Partner name Gene Name Score
136 Estrogen receptor ESR1 0.4099
6283 Oxysterols receptor LXR-alpha NR1H3 0.1277
88 Retinoic acid receptor RXR-beta RXRB 0.118
780 Retinoic acid receptor RXR-gamma RXRG 0.0923
6228 Nuclear receptor coactivator 1 NCOA1 0.0922
229 Retinoic acid receptor beta RARB 0.0598
730 Retinoic acid receptor alpha RARA 0.058
162 Retinoic acid receptor gamma-1 RARG 0.0553
6350 Nuclear receptor subfamily 1 group I member 3 NR1I3 0.0432
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0345
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0333
20 Prostaglandin G/H synthase 1 PTGS1 0.0298
4757 Cytochrome P450 2C9 CYP2C9 0.0286
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0286
5934 Cytochrome P450 26A1 CYP26A1 0.0283
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0264
290 Prostaglandin G/H synthase 2 PTGS2 0.0244
4512 Cytochrome P450 3A4 CYP3A4 0.0231
587 Serum albumin ALB 0.023
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0225
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0202
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0201
146 Androgen receptor AR 0.0184
614 Progesterone receptor PGR 0.0178
2907 Oxysterols receptor LXR-beta NR1H2 0.0172
275 Arachidonate 5-lipoxygenase ALOX5 0.0171
331 Retinol-binding protein I, cellular RBP1 0.0164
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0155
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0147
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0138
1588 Multidrug resistance protein 1 ABCB1 0.0131
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0129
4924 Cytochrome P450 2C8 CYP2C8 0.0129
703 NADPH azoreductase azr 0.0122
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0113
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.011
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0108
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0104
4200 Cytochrome P450 1A2 CYP1A2 0.0102
6016 Cytochrome P450 2C19 CYP2C19 0.0102
3811 Cytochrome P450 19A1 CYP19A1 0.0101
1729 Solute carrier family 22 member 6 SLC22A6 0.0096
992 Protein tyrosine kinase 2 beta PTK2B 0.0078
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0076
70 Type-1 angiotensin II receptor AGTR1 0.0063
862 Multidrug resistance-associated protein 1 ABCC1 0.0061
869 Estrogen receptor beta ESR2 0.0058
1757 Myeloperoxidase MPO 0.0058
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0055
373 Transthyretin TTR 0.0055
759 Free fatty acid receptor 1 FFAR1 0.0054
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0054
4119 Cytochrome P450 2D6 CYP2D6 0.0052
1053 BC269730_2 FADS1 0.0047
1395 Sodium/calcium exchanger 1 SLC8A1 0.0047
6024 Cytochrome P450 1A1 CYP1A1 0.0045
817 DNA topoisomerase 2-alpha TOP2A 0.0044
1650 Heme carrier protein 1 SLC46A1 0.0044
3312 Fatty acid-binding protein, brain FABP7 0.0044
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0044
4118 Cytochrome P450 3A5 CYP3A5 0.0043
2164 Multidrug resistance-associated protein 4 ABCC4 0.0041
33 Cystine/glutamate transporter SLC7A11 0.004
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0037
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0036
2021 Thrombomodulin THBD 0.0027
6221 Steroid hormone receptor ERR1 ESRRA 0.0026
267 Plasminogen activator inhibitor 1 SERPINE1 0.0025
5718 Cytochrome P450 2A6 CYP2A6 0.0024
6107 Cytochrome P450 3A7 CYP3A7 0.0024
1024 Solute carrier family 22 member 11 SLC22A11 0.0023
738 Monocarboxylate transporter 1 SLC16A1 0.0023
6042 Prostaglandin reductase 2 PTGR2 0.0023
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0021
3809 Estrogen-related receptor gamma ESRRG 0.0021
6142 Solute carrier family 22 member 8 SLC22A8 0.002
1792 Tissue-type plasminogen activator PLAT 0.002
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.002
6043 Putative G-protein coupled receptor 44 GPR44 0.002
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0019
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0019
1313 Lactoylglutathione lyase GLO1 0.0018
273 Apoptosis regulator Bcl-2 BCL2 0.0018
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0018
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0017
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0017
2981 Phospholipase A2, membrane associated PLA2G2A 0.0017
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0017
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0016
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0015
6141 Sodium/bile acid cotransporter SLC10A1 0.0014
4604 Liver carboxylesterase 1 CES1 0.0014
6137 Multidrug resistance-associated protein 6 ABCC6 0.0013
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0013
776 Bile salt export pump ABCB11 0.0013
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0012
6143 Solute carrier family 22 member 7 SLC22A7 0.0011
6030 Cytochrome P450 2B6 CYP2B6 0.001
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