DT-Web

DB08361 - 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide


Identification
Name 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide
Accession Number DB08361
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 340.4228
Groups experimental
Monoisotopic Weight 340.20115942
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Tyrosine-protein kinase SYK
Name Tyrosine-protein kinase SYK
Gene Name SYK
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.3756

Predictions


Id Partner name Gene Name Score
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0317
2473 Tyrosine-protein kinase CSK CSK 0.0313
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0273
2530 Protein kinase C theta type PRKCQ 0.0251
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0206
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.019
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0182
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0182
1721 Glycogen synthase kinase-3 beta GSK3B 0.0168
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0167
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0145
997 Protein kinase C beta type PRKCB 0.0143
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0125
6131 Carbonic anhydrase 14 CA14 0.0125
1970 Protein kinase C alpha type PRKCA 0.0124
6122 Carbonic anhydrase 3 CA3 0.0122
2240 Cell division protein kinase 2 CDK2 0.0117
634 Squalene monooxygenase SQLE 0.0113
7196 Squalene monooxygenase ERG1 0.0113
2236 Casein kinase II subunit alpha CSNK2A1 0.0108
4205 Carbonic anhydrase 9 CA9 0.0104
3007 Carbonic anhydrase 12 CA12 0.0104
6126 Carbonic anhydrase 7 CA7 0.0098
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0095
357 Carbonic anhydrase 2 CA2 0.0075
592 Carbonic anhydrase 4 CA4 0.0075
295 Carbonic anhydrase 1 CA1 0.0074
1588 Multidrug resistance protein 1 ABCB1 0.0071
1024 Solute carrier family 22 member 11 SLC22A11 0.0066
6024 Cytochrome P450 1A1 CYP1A1 0.0055
1729 Solute carrier family 22 member 6 SLC22A6 0.0053
6013 Cytochrome P450 2E1 CYP2E1 0.0053
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