DT-Web

DB08341 - 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide


Identification
Name 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Accession Number DB08341
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 458.501
Groups experimental
Monoisotopic Weight 458.171179379
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Protein tyrosine kinase 2 beta
Name Protein tyrosine kinase 2 beta
Gene Name PTK2B
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6715

Predictions


Id Partner name Gene Name Score
6220 Aryl hydrocarbon receptor AHR 0.0599
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0501
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0482
4200 Cytochrome P450 1A2 CYP1A2 0.0403
6228 Nuclear receptor coactivator 1 NCOA1 0.0269
6241 Nuclear receptor coactivator 2 NCOA2 0.0266
4757 Cytochrome P450 2C9 CYP2C9 0.0253
869 Estrogen receptor beta ESR2 0.0245
373 Transthyretin TTR 0.0228
817 DNA topoisomerase 2-alpha TOP2A 0.0224
136 Estrogen receptor ESR1 0.0201
862 Multidrug resistance-associated protein 1 ABCC1 0.019
1588 Multidrug resistance protein 1 ABCB1 0.0137
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