DT-Web

DB07840 - (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol


Identification
Name (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol
Accession Number DB07840
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 364.3449
Groups experimental
Monoisotopic Weight 364.102334112
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Basic fibroblast growth factor receptor 1
Name Basic fibroblast growth factor receptor 1
Gene Name FGFR1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.904

Predictions


Id Partner name Gene Name Score
823 Fibroblast growth factor receptor 2 FGFR2 0.1694
2216 Fibroblast growth factor receptor 4 FGFR4 0.0605
3856 Fibroblast growth factor receptor 3 FGFR3 0.0563
1585 Basement membrane-specific heparan sulfate proteoglycan core protein HSPG2 0.0537
3852 Neuropilin-1 NRP1 0.0468
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0272
504 Mast/stem cell growth factor receptor KIT 0.0226
407 Vascular endothelial growth factor receptor 2 KDR 0.0216
5787 Angiopoietin-1 receptor TEK 0.0207
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0188
165 FL cytokine receptor FLT3 0.0186
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0175
26 Vascular endothelial growth factor receptor 3 FLT4 0.0167
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0164
32 Vascular endothelial growth factor receptor 1 FLT1 0.0163
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0151
228 Beta platelet-derived growth factor receptor PDGFRB 0.0145
5798 Mitogen-activated protein kinase 11 MAPK11 0.0129
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0126
6824 Tyrosine-protein kinase Lyn LYN 0.0118
4924 Cytochrome P450 2C8 CYP2C8 0.0105
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.01
1588 Multidrug resistance protein 1 ABCB1 0.0097
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0093
936 Ephrin type-A receptor 2 EPHA2 0.0091
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0086
4512 Cytochrome P450 3A4 CYP3A4 0.0085
1618 High affinity nerve growth factor receptor NTRK1 0.0083
6030 Cytochrome P450 2B6 CYP2B6 0.0072
4118 Cytochrome P450 3A5 CYP3A5 0.0072
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0068
4119 Cytochrome P450 2D6 CYP2D6 0.0065
6016 Cytochrome P450 2C19 CYP2C19 0.0063
4757 Cytochrome P450 2C9 CYP2C9 0.006
776 Bile salt export pump ABCB11 0.0054
2164 Multidrug resistance-associated protein 4 ABCC4 0.0044
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0039
6107 Cytochrome P450 3A7 CYP3A7 0.0034
4200 Cytochrome P450 1A2 CYP1A2 0.0031
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