DT-Web

DB07670 - 4-METHYL-N-METHYL-N-(2-PHENYL-2H-PYRAZOL-3-YL)BENZENESULFONAMIDE


Identification
Name 4-METHYL-N-METHYL-N-(2-PHENYL-2H-PYRAZOL-3-YL)BENZENESULFONAMIDE
Accession Number DB07670
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 327.401
Groups experimental
Monoisotopic Weight 327.104147493
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.1471

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.0498
4924 Cytochrome P450 2C8 CYP2C8 0.043
4757 Cytochrome P450 2C9 CYP2C9 0.0429
4512 Cytochrome P450 3A4 CYP3A4 0.039
6030 Cytochrome P450 2B6 CYP2B6 0.0303
4200 Cytochrome P450 1A2 CYP1A2 0.0266
4119 Cytochrome P450 2D6 CYP2D6 0.0264
6107 Cytochrome P450 3A7 CYP3A7 0.0219
5718 Cytochrome P450 2A6 CYP2A6 0.0215
4118 Cytochrome P450 3A5 CYP3A5 0.0205
1588 Multidrug resistance protein 1 ABCB1 0.0192
20 Prostaglandin G/H synthase 1 PTGS1 0.0133
468 Cytochrome P450 4A11 CYP4A11 0.0129
6024 Cytochrome P450 1A1 CYP1A1 0.0123
85 Growth hormone receptor GHR 0.0119
824 Sodium-dependent serotonin transporter SLC6A4 0.0103
6013 Cytochrome P450 2E1 CYP2E1 0.0103
1729 Solute carrier family 22 member 6 SLC22A6 0.0096
1898 Cytochrome P450 1B1 CYP1B1 0.0084
118 Organic cation/carnitine transporter 2 SLC22A5 0.0082
587 Serum albumin ALB 0.008
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0079
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0075
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.007
320 5-hydroxytryptamine 1A receptor HTR1A 0.0068
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0067
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0065
6174 50S ribosomal protein L32 rpmF 0.0063
4238 50S ribosomal protein L4 rplD 0.0063
5578 50S ribosomal protein L4 rplD 0.0063
6173 50S ribosomal protein L4 rplD 0.0063
6219 50S ribosomal protein L4 rplD 0.0063
3426 Glutamine synthetase glnA 0.006
3987 Glutamine synthetase GLUL 0.006
290 Prostaglandin G/H synthase 2 PTGS2 0.006
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0059
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0058
6145 Solute carrier family 22 member 1 SLC22A1 0.0058
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0056
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0053
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0053
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0052
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0052
6144 Solute carrier family 22 member 2 SLC22A2 0.0052
3808 Dihydropteroate synthase 2 folP2 0.005
492 Histamine H1 receptor HRH1 0.005
3601 Dihydropteroate synthase 1 folP1 0.005
3807 Dihydropteroate synthase 1 folP1 0.005
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0049
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0049
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0049
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0049
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0049
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0049
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0048
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0048
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0048
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0048
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0048
380 Cytochrome P450 17A1 CYP17A1 0.0047
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0047
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0047
467 Delta-type opioid receptor OPRD1 0.0046
847 Mu-type opioid receptor OPRM1 0.0044
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0044
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0043
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0043
6031 Cytochrome P450 3A43 CYP3A43 0.0041
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.004
3923 Cholinesterase BCHE 0.004
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0038
6432 Transporter snf 0.0037
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0037
465 Calmodulin CALM1 0.0036
833 Organic cation/carnitine transporter 1 SLC22A4 0.0036
719 Retinoic acid receptor responder protein 1 RARRES1 0.0035
770 Retinoic acid-induced protein 3 GPRC5A 0.0035
6102 Arylamine N-acetyltransferase 2 NAT2 0.0035
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0034
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0033
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0032
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0032
844 Epidermal growth factor receptor EGFR 0.0031
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0031
23 D(1A) dopamine receptor DRD1 0.0031
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0031
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0031
862 Multidrug resistance-associated protein 1 ABCC1 0.0031
84 Nuclear receptor 0B1 NR0B1 0.003
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.003
569 Retinal dehydrogenase 2 ALDH1A2 0.003
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.003
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.003
831 D(2) dopamine receptor DRD2 0.0029
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0028
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0028
611 Retinal dehydrogenase 1 ALDH1A1 0.0028
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0027
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0027
1039 Histone deacetylase 9 HDAC9 0.0027
1757 Myeloperoxidase MPO 0.0027
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0027
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0027
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0026
1360 Sphingomyelin phosphodiesterase SMPD1 0.0026
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0026
6147 Solute carrier family 22 member 3 SLC22A3 0.0026
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0026
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0026
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0025
780 Retinoic acid receptor RXR-gamma RXRG 0.0025
3937 Fatty-acid amide hydrolase FAAH 0.0024
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0024
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0023
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0023
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0023
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0023
696 Kappa-type opioid receptor OPRK1 0.0023
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0023
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0022
6142 Solute carrier family 22 member 8 SLC22A8 0.0022
88 Retinoic acid receptor RXR-beta RXRB 0.0022
502 5-hydroxytryptamine 2A receptor HTR2A 0.0022
162 Retinoic acid receptor gamma-1 RARG 0.0022
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0022
3811 Cytochrome P450 19A1 CYP19A1 0.0022
556 Alpha-1A adrenergic receptor ADRA1A 0.0022
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0022
2164 Multidrug resistance-associated protein 4 ABCC4 0.0021
776 Bile salt export pump ABCB11 0.0021
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.002
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.002
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.002
275 Arachidonate 5-lipoxygenase ALOX5 0.002
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0019
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0018
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0018
2981 Phospholipase A2, membrane associated PLA2G2A 0.0016
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0015
738 Monocarboxylate transporter 1 SLC16A1 0.0015
811 Translocator protein TSPO 0.0014
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0014
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0014
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0014
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0014
789 Alpha-1D adrenergic receptor ADRA1D 0.0014
6143 Solute carrier family 22 member 7 SLC22A7 0.0013
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0013
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0013
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0013
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0013
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0013
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0013
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0013
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0013
373 Transthyretin TTR 0.0013
1024 Solute carrier family 22 member 11 SLC22A11 0.0013
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0012
193 Beta-1 adrenergic receptor ADRB1 0.0012
766 Beta-2 adrenergic receptor ADRB2 0.0012
921 Glutamate receptor 2 GRIA2 0.0012
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0011
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0011
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0011
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0011
6148 Multidrug resistance-associated protein 7 ABCC10 0.0011
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.001
4954 Soluble cytochrome b558 Not Available 0.001
4934 Cytochrome c-551 nirM 0.001
5218 Cytochrome c-551 nirM 0.001
4905 Cytochrome c2 Not Available 0.001
4939 Cytochrome c2 cycA 0.001
4964 Cytochrome c2 cycA 0.001
4979 Cytochrome c2 cycA 0.001
6673 Cytochrome c2 cycA 0.001
4915 Cytochrome c-550 psbV 0.001
4959 Cytochrome c-550 psbV 0.001
5216 Cytochrome c-550 psbV 0.001
4925 Cytochrome c-type protein SHP shp 0.001
4998 Hemoglobin-like protein yjbI yjbI 0.001
4947 Bacterial hemoglobin vhb 0.001
4975 Cytochrome c-556 RPA3973 0.001
4984 Neuroglobin NGB 0.001
4943 Cytochrome c6 petJ 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
4907 Cytochrome c-L moxG 0.0009
6865 Cytochrome c-L moxG 0.0009
4936 Cytochrome c2 iso-2 Not Available 0.0009
4916 Cyanoglobin glbN 0.0009
4909 CooA protein cooA 0.0009
4994 Hemoglobin-like protein HbO glbO 0.0009
644 Heme oxygenase 2 HMOX2 0.0009
4982 Heme oxygenase 2 pbsA2 0.0009
4942 Diheme cytochrome c napB napB 0.0009
4935 Cytochrome c-554 cycA1 0.0009
4971 Nonaheme cytochrome c hmcA 0.0009
4989 Cytochrome c551 peroxidase ccp 0.0009
5222 Cytochrome c551 peroxidase ccpA 0.0009
4961 Hemophore HasA hasA 0.0009
4910 Cytoglobin CYGB 0.0009
4976 Apocytochrome f petA 0.0009
6407 Apocytochrome f petA 0.0009
4904 Cytochrome c family protein GSU1996 0.0009
4981 Iron-starvation protein PigA pigA 0.0009
4999 Cytochrome P450 165B3 CYP165B3 0.0009
4764 Cytochrome P450 165C4 CYP165C4 0.0009
4960 Putative cytochrome P450-family protein SCO7417 0.0009
5000 HemO hemO 0.0009
4931 Cytochrome P450 167A1 CYP167A1 0.0009
4926 Heme-based aerotactic transducer hemAT hemAT 0.0009
4937 Cytochrome oxidase subunit II rcoxA 0.0009
4993 Hydroxylamine oxidoreductase hao1 0.0009
4903 Methyl-accepting chemotaxis protein Tar4 0.0009
4972 P450cin cinA 0.0009
3093 Catalase HPII katE 0.0009
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0009
4922 Cytochrome c, putative SO_4144 0.0009
4952 Catalase/peroxidase katA 0.0009
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0009
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0008
4920 Peroxidase/catalase katG 0.0007
4948 Cytochrome c-553 Not Available 0.0007
4923 Cytochrome c3 DvMF_2499 0.0007
4945 Cytochrome c3 Not Available 0.0007
4949 Cytochrome c3 DVU_3171 0.0007
4968 Cytochrome c3 cytc3 0.0007
4997 Cytochrome c3 SO_2727 0.0007
5219 Cytochrome c3 cyd 0.0007
2119 Cytochrome b5 CYB5A 0.0007
4902 Nine-heme cytochrome c Ddes_2038 0.0007
3189 High-molecular-weight cytochrome c hmcA 0.0007
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0007
4990 PpcA ppcA 0.0007
4988 Sulfite oxidase, mitochondrial SUOX 0.0007
3375 Acidic cytochrome c3 Not Available 0.0007
4385 Cytochrome c' Not Available 0.0007
4967 Cytochrome c' cycA 0.0007
5038 Cytochrome c' Not Available 0.0007
5223 Cytochrome c' cycP 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
3570 Cytochrome P450 152A1 cypC 0.0007
2915 Sensor protein fixL fixL 0.0007
4944 Sensor protein fixL fixL 0.0007
4992 Cytochrome c peroxidase Not Available 0.0007
4289 Cytochrome P450 TT_P0059 0.0007
6262 Cytochrome P450 staP 0.0007
2230 Catalase CAT 0.0007
3249 Catalase katA 0.0007
3625 Catalase katA 0.0007
4539 Catalase katA 0.0007
4941 Catalase katB 0.0007
4813 Heme oxygenase hmuO 0.0007
5769 Heme oxygenase Not Available 0.0007
3670 Soluble cytochrome b562 precursor cybC 0.0006
3411 Cytochrome P450 121 cyp121 0.0006
3291 Cytochrome c-552 cycA 0.0006
4927 Cytochrome c-552 nrfA 0.0006
4938 Cytochrome c-552 cycA 0.0006
4953 Cytochrome c-552 nrfA 0.0006
5217 Cytochrome c-552 cycM 0.0006
2617 Nitric oxide synthase oxygenase nos 0.0006
2701 Nitric oxide synthase oxygenase nos 0.0006
4386 Hemoglobin-like protein HbN glbN 0.0006
518 Peroxidase/catalase T katG 0.0006
3102 Flavohemoprotein hmp 0.0006
4969 Flavohemoprotein hmp 0.0006
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
605 Fumarate reductase flavoprotein subunit frdA 0.0005
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0005
3673 Fumarate reductase flavoprotein subunit fccA 0.0005
4912 Fumarate reductase flavoprotein subunit ifcA 0.0005
6549 Fumarate reductase flavoprotein subunit frdA 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
3221 Cytochrome c4 cc4 0.0005
4608 Putative cytochrome P450 SCO1207 0.0005
4963 Putative cytochrome P450 SCO2884 0.0005
6254 Putative cytochrome P450 SCO6998 0.0005
358 Cystathionine beta-synthase CBS 0.0005
260 Cytochrome P450 51 ERG11 0.0005
761 Cytochrome P450 51 ERG11 0.0005
3163 Cytochrome P450 51 cyp51 0.0005
1507 Cytochrome c CYCS 0.0005
693 Hemoglobin subunit beta HBB 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
2298 Cytochrome P450-cam camC 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0003
7 Nitric oxide synthase, inducible NOS2 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
↑