DT-Web

DB07664 - 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE


Identification
Name 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Accession Number DB07664
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 425.436
Groups experimental
Monoisotopic Weight 425.054020485
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Casein kinase I isoform gamma-3
Name Casein kinase I isoform gamma-3
Gene Name CSNK1G3
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.7929
STE20-like serine/threonine-protein kinase
Name STE20-like serine/threonine-protein kinase
Gene Name SLK
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2311
Calcium/calmodulin-dependent protein kinase type IV
Name Calcium/calmodulin-dependent protein kinase type IV
Gene Name CAMK4
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2309
Dual specificity protein kinase CLK3
Name Dual specificity protein kinase CLK3
Gene Name CLK3
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2312
Tyrosine-protein kinase ABL2
Name Tyrosine-protein kinase ABL2
Gene Name ABL2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5742

Predictions


Id Partner name Gene Name Score
6612 Serine/threonine-protein kinase MST4 MST4 0.4892
3318 Dual specificity protein kinase CLK1 CLK1 0.4301
1721 Glycogen synthase kinase-3 beta GSK3B 0.2632
6782 Ribosomal protein S6 kinase alpha-1 RPS6KA1 0.1873
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.1011
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0299
1063 Signal transducer and activator of transcription 5B STAT5B 0.0298
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0282
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0255
936 Ephrin type-A receptor 2 EPHA2 0.0247
228 Beta platelet-derived growth factor receptor PDGFRB 0.0196
504 Mast/stem cell growth factor receptor KIT 0.0184
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0179
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0167
340 Apoptotic protease-activating factor 1 APAF1 0.0158
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0156
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0156
395 ALK tyrosine kinase receptor Not Available 0.0156
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0156
733 Activin receptor type 1B ACVR1B 0.0156
825 Arsenical pump-driving ATPase ASNA1 0.0156
3435 Arsenical pump-driving ATPase arsA 0.0156
154 AFG3-like protein 2 AFG3L2 0.0156
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0156
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0156
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0156
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0156
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0156
292 Activin receptor type-1 ACVR1 0.0136
849 Activated CDC42 kinase 1 TNK2 0.0135
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0132
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0132
297 Adenylate cyclase type 1 ADCY1 0.0132
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0132
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0127
1588 Multidrug resistance protein 1 ABCB1 0.0126
1898 Cytochrome P450 1B1 CYP1B1 0.0125
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0124
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0115
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0111
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0109
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0106
6021 Adenosine kinase ADK 0.0106
661 ADP/ATP translocase 1 SLC25A4 0.0104
6024 Cytochrome P450 1A1 CYP1A1 0.0102
740 Argininosuccinate synthase ASS1 0.01
865 Argininosuccinate synthase ASS1 0.01
2680 Argininosuccinate synthase argG 0.01
3194 Argininosuccinate synthase argG 0.01
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0094
4118 Cytochrome P450 3A5 CYP3A5 0.009
4200 Cytochrome P450 1A2 CYP1A2 0.0085
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0081
4512 Cytochrome P450 3A4 CYP3A4 0.0072
776 Bile salt export pump ABCB11 0.0066
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0056
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