DT-Web

DB07609 - N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE


Identification
Name N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE
Accession Number DB07609
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 202.2524
Groups experimental
Monoisotopic Weight 202.11061308
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.2188

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.0476
4757 Cytochrome P450 2C9 CYP2C9 0.0436
6013 Cytochrome P450 2E1 CYP2E1 0.0371
4119 Cytochrome P450 2D6 CYP2D6 0.0369
4200 Cytochrome P450 1A2 CYP1A2 0.0367
6016 Cytochrome P450 2C19 CYP2C19 0.0344
6030 Cytochrome P450 2B6 CYP2B6 0.0336
4924 Cytochrome P450 2C8 CYP2C8 0.0278
6024 Cytochrome P450 1A1 CYP1A1 0.0257
1588 Multidrug resistance protein 1 ABCB1 0.0211
4118 Cytochrome P450 3A5 CYP3A5 0.0156
6106 Cytochrome P450 2C18 CYP2C18 0.0129
6107 Cytochrome P450 3A7 CYP3A7 0.0126
3811 Cytochrome P450 19A1 CYP19A1 0.012
6014 Cytochrome P450 2A13 CYP2A13 0.0109
20 Prostaglandin G/H synthase 1 PTGS1 0.0108
766 Beta-2 adrenergic receptor ADRB2 0.0073
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0067
2230 Catalase CAT 0.0065
3249 Catalase katA 0.0065
3625 Catalase katA 0.0065
4539 Catalase katA 0.0065
4941 Catalase katB 0.0065
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0063
468 Cytochrome P450 4A11 CYP4A11 0.0063
6102 Arylamine N-acetyltransferase 2 NAT2 0.0062
118 Organic cation/carnitine transporter 2 SLC22A5 0.0062
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.006
4238 50S ribosomal protein L4 rplD 0.0059
5578 50S ribosomal protein L4 rplD 0.0059
6173 50S ribosomal protein L4 rplD 0.0059
6219 50S ribosomal protein L4 rplD 0.0059
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0056
1729 Solute carrier family 22 member 6 SLC22A6 0.0056
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0055
4237 50S ribosomal protein L22 rplV 0.0054
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0053
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0052
587 Serum albumin ALB 0.0051
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0051
6144 Solute carrier family 22 member 2 SLC22A2 0.0051
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0051
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.005
1898 Cytochrome P450 1B1 CYP1B1 0.005
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.005
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0048
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
590 5-hydroxytryptamine 2C receptor HTR2C 0.0046
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0046
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0046
537 ATP synthase delta chain, mitochondrial ATP5D 0.0046
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0046
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0045
251 Alcohol dehydrogenase 1A ADH1A 0.0045
492 Histamine H1 receptor HRH1 0.0044
136 Estrogen receptor ESR1 0.0044
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0044
6147 Solute carrier family 22 member 3 SLC22A3 0.0043
482 Glycine receptor subunit alpha-1 GLRA1 0.0043
776 Bile salt export pump ABCB11 0.0042
341 5-hydroxytryptamine 3 receptor HTR3A 0.0041
3941 Amine oxidase [flavin-containing] A MAOA 0.0041
3939 Amine oxidase [flavin-containing] B MAOB 0.0041
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0041
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0041
444 Alcohol dehydrogenase 1B ADH1B 0.004
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.004
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.004
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0039
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0039
891 Dihydropteroate synthase folP 0.0039
5359 Dihydropteroate synthase folP 0.0039
7175 Dihydropteroate synthase sulI 0.0039
705 Glutamate receptor 1 GRIA1 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
713 Sodium-dependent dopamine transporter SLC6A3 0.0038
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0037
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0037
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0037
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0037
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0037
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0037
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0037
6031 Cytochrome P450 3A43 CYP3A43 0.0037
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0036
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0036
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0036
517 Alcohol dehydrogenase 1C ADH1C 0.0035
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0034
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0034
871 Glucocorticoid receptor NR3C1 0.0034
232 Corticosteroid-binding globulin SERPINA6 0.0032
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0032
6143 Solute carrier family 22 member 7 SLC22A7 0.0032
2298 Cytochrome P450-cam camC 0.0031
106 Cannabinoid receptor 2 CNR2 0.0031
260 Cytochrome P450 51 ERG11 0.0031
761 Cytochrome P450 51 ERG11 0.0031
3163 Cytochrome P450 51 cyp51 0.0031
518 Peroxidase/catalase T katG 0.0031
6174 50S ribosomal protein L32 rpmF 0.0031
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.003
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.003
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.003
6136 Multidrug resistance-associated protein 5 ABCC5 0.003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0029
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0029
3932 Glutathione S-transferase A2 GSTA2 0.0029
68 Cannabinoid receptor 1 CNR1 0.0029
563 Thyroid peroxidase TPO 0.0029
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0029
131 Synaptic vesicular amine transporter SLC18A2 0.0029
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0029
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0028
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0028
275 Arachidonate 5-lipoxygenase ALOX5 0.0027
824 Sodium-dependent serotonin transporter SLC6A4 0.0027
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0027
465 Calmodulin CALM1 0.0027
1192 Sulfotransferase 1A1 SULT1A1 0.0026
84 Nuclear receptor 0B1 NR0B1 0.0026
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0025
528 5-hydroxytryptamine 1E receptor HTR1E 0.0024
3917 Methylenetetrahydrofolate reductase MTHFR 0.0024
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0023
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0022
869 Estrogen receptor beta ESR2 0.0022
921 Glutamate receptor 2 GRIA2 0.0021
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0021
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0021
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0021
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
502 5-hydroxytryptamine 2A receptor HTR2A 0.002
290 Prostaglandin G/H synthase 2 PTGS2 0.002
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.002
1181 Alpha-1-acid glycoprotein 1 ORM1 0.002
400 Coagulation factor IX F9 0.002
5461 Coagulation factor IX F9 0.002
540 Sodium-dependent noradrenaline transporter SLC6A2 0.002
380 Cytochrome P450 17A1 CYP17A1 0.002
3809 Estrogen-related receptor gamma ESRRG 0.002
477 DNA topoisomerase 4 subunit A parC 0.002
886 DNA topoisomerase 4 subunit A parC 0.002
6226 DNA topoisomerase 4 subunit A parC 0.002
4226 Uridine phosphorylase 2 UPP2 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
404 DNA gyrase subunit A gyrA 0.0019
6224 DNA gyrase subunit A gyrA 0.0019
2164 Multidrug resistance-associated protein 4 ABCC4 0.0019
94 5-hydroxytryptamine 4 receptor HTR4 0.0019
511 5-hydroxytryptamine 1F receptor HTR1F 0.0019
862 Multidrug resistance-associated protein 1 ABCC1 0.0018
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0018
604 Vitamin K-dependent protein Z PROZ 0.0018
725 5-hydroxytryptamine 1D receptor HTR1D 0.0018
885 5-hydroxytryptamine 1B receptor HTR1B 0.0018
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0018
4225 Uridine phosphorylase 1 UPP1 0.0018
817 DNA topoisomerase 2-alpha TOP2A 0.0017
6145 Solute carrier family 22 member 1 SLC22A1 0.0017
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0017
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0017
719 Retinoic acid receptor responder protein 1 RARRES1 0.0017
770 Retinoic acid-induced protein 3 GPRC5A 0.0017
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
413 Amidophosphoribosyltransferase PPAT 0.0017
2515 Amidophosphoribosyltransferase purF 0.0017
3714 Amidophosphoribosyltransferase purF 0.0017
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0016
320 5-hydroxytryptamine 1A receptor HTR1A 0.0016
3810 Catechol O-methyltransferase COMT 0.0016
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0016
844 Epidermal growth factor receptor EGFR 0.0016
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
569 Retinal dehydrogenase 2 ALDH1A2 0.0015
831 D(2) dopamine receptor DRD2 0.0014
436 5-hydroxytryptamine 2B receptor HTR2B 0.0014
1275 Estrogen sulfotransferase SULT1E1 0.0014
6142 Solute carrier family 22 member 8 SLC22A8 0.0014
7 Nitric oxide synthase, inducible NOS2 0.0014
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0014
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0014
611 Retinal dehydrogenase 1 ALDH1A1 0.0014
1268 Neuropeptide S receptor NPSR1 0.0014
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0014
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0014
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0014
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0014
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0014
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0014
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0014
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0014
798 Osteocalcin BGLAP 0.0014
3639 Thymidine phosphorylase deoA 0.0014
3936 Thymidine phosphorylase TYMP 0.0014
1050 Bile salt sulfotransferase SULT2A1 0.0014
373 Transthyretin TTR 0.0014
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0013
811 Translocator protein TSPO 0.0013
5934 Cytochrome P450 26A1 CYP26A1 0.0013
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0013
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0013
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0013
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0013
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0013
833 Organic cation/carnitine transporter 1 SLC22A4 0.0013
6073 Potassium channel subfamily K member 9 KCNK9 0.0012
6072 Potassium channel subfamily K member 3 KCNK3 0.0012
1360 Sphingomyelin phosphodiesterase SMPD1 0.0012
369 Coagulation factor VII F7 0.0012
3937 Fatty-acid amide hydrolase FAAH 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0012
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0012
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0011
467 Delta-type opioid receptor OPRD1 0.0011
696 Kappa-type opioid receptor OPRK1 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0011
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0011
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0011
24 Thymidylate synthase TMP1 0.0011
359 Thymidylate synthase TYMS 0.0011
2626 Thymidylate synthase thyA 0.0011
2729 Thymidylate synthase thyA 0.0011
5352 Thymidylate synthase THYA 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0011
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0011
162 Retinoic acid receptor gamma-1 RARG 0.0011
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0011
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0011
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0011
847 Mu-type opioid receptor OPRM1 0.0011
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0011
469 Annexin A1 ANXA1 0.0011
6020 Aldehyde oxidase AOX1 0.001
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
284 DNA-directed RNA polymerase beta chain rpoB 0.001
5773 DNA-directed RNA polymerase beta chain rpoB 0.001
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.001
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.001
737 Mineralocorticoid receptor NR3C2 0.001
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.001
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.001
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.001
1024 Solute carrier family 22 member 11 SLC22A11 0.001
3947 Xanthine dehydrogenase/oxidase XDH 0.001
2207 Rhodopsin RHO 0.0009
295 Carbonic anhydrase 1 CA1 0.0009
6141 Sodium/bile acid cotransporter SLC10A1 0.0009
239 Coagulation factor X F10 0.0009
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0009
556 Alpha-1A adrenergic receptor ADRA1A 0.0009
6432 Transporter snf 0.0009
614 Progesterone receptor PGR 0.0009
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0009
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0009
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0008
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0008
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0008
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0008
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0008
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0008
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0008
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0008
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0008
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0008
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0008
164 Histamine H4 receptor HRH4 0.0008
4604 Liver carboxylesterase 1 CES1 0.0008
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0008
54 Prothrombin F2 0.0008
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0007
738 Monocarboxylate transporter 1 SLC16A1 0.0007
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0007
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0006
193 Beta-1 adrenergic receptor ADRB1 0.0006
432 D(4) dopamine receptor DRD4 0.0005
638 D(3) dopamine receptor DRD3 0.0005
378 Alpha-2C adrenergic receptor ADRA2C 0.0005
629 Alpha-2B adrenergic receptor ADRA2B 0.0005
632 Alpha-1B adrenergic receptor ADRA1B 0.0004
23 D(1A) dopamine receptor DRD1 0.0004
318 Alpha-2A adrenergic receptor ADRA2A 0.0004
↑