DT-Web

DB07422 - (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide


Identification
Name (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
Accession Number DB07422
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 474.2589
Groups experimental
Monoisotopic Weight 474.04619708
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Androgen receptor
Name Androgen receptor
Gene Name AR
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0315

Predictions


Id Partner name Gene Name Score
3811 Cytochrome P450 19A1 CYP19A1 0.0627
756 Sex hormone-binding globulin SHBG 0.0394
614 Progesterone receptor PGR 0.0297
737 Mineralocorticoid receptor NR3C2 0.0267
871 Glucocorticoid receptor NR3C1 0.0158
4512 Cytochrome P450 3A4 CYP3A4 0.0146
136 Estrogen receptor ESR1 0.0145
381 Prolactin receptor PRLR 0.013
6241 Nuclear receptor coactivator 2 NCOA2 0.013
6016 Cytochrome P450 2C19 CYP2C19 0.0129
3810 Catechol O-methyltransferase COMT 0.0119
4757 Cytochrome P450 2C9 CYP2C9 0.01
4924 Cytochrome P450 2C8 CYP2C8 0.0098
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0096
290 Prostaglandin G/H synthase 2 PTGS2 0.0092
3941 Amine oxidase [flavin-containing] A MAOA 0.0084
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0082
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0081
1588 Multidrug resistance protein 1 ABCB1 0.008
3939 Amine oxidase [flavin-containing] B MAOB 0.0078
4120 NADPH--cytochrome P450 reductase POR 0.0074
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0071
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0066
1649 Small inducible cytokine A2 CCL2 0.0063
380 Cytochrome P450 17A1 CYP17A1 0.0062
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0061
587 Serum albumin ALB 0.0059
6030 Cytochrome P450 2B6 CYP2B6 0.0059
4119 Cytochrome P450 2D6 CYP2D6 0.0055
226 Gonadotropin-releasing hormone receptor GNRHR 0.0054
373 Transthyretin TTR 0.0054
4118 Cytochrome P450 3A5 CYP3A5 0.0054
6220 Aryl hydrocarbon receptor AHR 0.0053
3923 Cholinesterase BCHE 0.0052
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0048
1898 Cytochrome P450 1B1 CYP1B1 0.0047
6142 Solute carrier family 22 member 8 SLC22A8 0.004
20 Prostaglandin G/H synthase 1 PTGS1 0.0039
6024 Cytochrome P450 1A1 CYP1A1 0.0038
1729 Solute carrier family 22 member 6 SLC22A6 0.0037
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0035
4200 Cytochrome P450 1A2 CYP1A2 0.0024
6014 Cytochrome P450 2A13 CYP2A13 0.0018
6141 Sodium/bile acid cotransporter SLC10A1 0.0014
6031 Cytochrome P450 3A43 CYP3A43 0.0014
833 Organic cation/carnitine transporter 1 SLC22A4 0.0011
6147 Solute carrier family 22 member 3 SLC22A3 0.0011
6143 Solute carrier family 22 member 7 SLC22A7 0.001
6145 Solute carrier family 22 member 1 SLC22A1 0.0009
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0009
6107 Cytochrome P450 3A7 CYP3A7 0.0008
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