DT-Web

DB07354 - 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM


Identification
Name 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM
Accession Number DB07354
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 322.3346
Groups experimental
Monoisotopic Weight 322.107933005
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


DNA topoisomerase 1
Name DNA topoisomerase 1
Gene Name TOP1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9971

Predictions


Id Partner name Gene Name Score
3552 DNA topoisomerase 1 topA 0.9971
4180 DNA-(apurinic or apyrimidinic site) lyase APEX1 0.1088
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0647
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0608
1588 Multidrug resistance protein 1 ABCB1 0.0467
817 DNA topoisomerase 2-alpha TOP2A 0.0423
4512 Cytochrome P450 3A4 CYP3A4 0.0178
4604 Liver carboxylesterase 1 CES1 0.0086
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0076
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0071
6147 Solute carrier family 22 member 3 SLC22A3 0.007
3923 Cholinesterase BCHE 0.0065
862 Multidrug resistance-associated protein 1 ABCC1 0.0064
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0064
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0059
587 Serum albumin ALB 0.0055
6030 Cytochrome P450 2B6 CYP2B6 0.0054
6107 Cytochrome P450 3A7 CYP3A7 0.0052
4118 Cytochrome P450 3A5 CYP3A5 0.005
↑