DT-Web

DB07326 - 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide


Identification
Name 6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide
Accession Number DB07326
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 433.771
Groups experimental
Monoisotopic Weight 433.055336943
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Vascular endothelial growth factor receptor 2
Name Vascular endothelial growth factor receptor 2
Gene Name KDR
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2592

Predictions


Id Partner name Gene Name Score
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0346
26 Vascular endothelial growth factor receptor 3 FLT4 0.0318
32 Vascular endothelial growth factor receptor 1 FLT1 0.0314
504 Mast/stem cell growth factor receptor KIT 0.0225
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0214
1144 Hepatocyte growth factor receptor MET 0.0197
228 Beta platelet-derived growth factor receptor PDGFRB 0.0187
4512 Cytochrome P450 3A4 CYP3A4 0.0186
165 FL cytokine receptor FLT3 0.0162
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0141
1588 Multidrug resistance protein 1 ABCB1 0.0136
3856 Fibroblast growth factor receptor 3 FGFR3 0.0135
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0129
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0127
4757 Cytochrome P450 2C9 CYP2C9 0.0107
4118 Cytochrome P450 3A5 CYP3A5 0.0106
5787 Angiopoietin-1 receptor TEK 0.0104
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0093
823 Fibroblast growth factor receptor 2 FGFR2 0.0092
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0085
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0082
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0079
4200 Cytochrome P450 1A2 CYP1A2 0.0078
4924 Cytochrome P450 2C8 CYP2C8 0.0077
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0076
6016 Cytochrome P450 2C19 CYP2C19 0.0071
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0069
2216 Fibroblast growth factor receptor 4 FGFR4 0.0066
5798 Mitogen-activated protein kinase 11 MAPK11 0.0063
6824 Tyrosine-protein kinase Lyn LYN 0.0059
2164 Multidrug resistance-associated protein 4 ABCC4 0.0059
760 Fibroblast growth factor 1 FGF1 0.0055
4119 Cytochrome P450 2D6 CYP2D6 0.0055
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0052
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.005
6107 Cytochrome P450 3A7 CYP3A7 0.0046
936 Ephrin type-A receptor 2 EPHA2 0.0045
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0043
1618 High affinity nerve growth factor receptor NTRK1 0.0041
6030 Cytochrome P450 2B6 CYP2B6 0.0036
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0034
776 Bile salt export pump ABCB11 0.0028
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