DT-Web

DB07156 - (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione


Identification
Name (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione
Accession Number DB07156
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 426.306
Groups experimental
Monoisotopic Weight 425.073889546
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Insulin-like growth factor 1 receptor
Name Insulin-like growth factor 1 receptor
Gene Name IGF1R
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6893

Predictions


Id Partner name Gene Name Score
36 Insulin receptor INSR 0.1974
1350 Insulin-like growth factor-binding protein 3 IGFBP3 0.0734
4200 Cytochrome P450 1A2 CYP1A2 0.0708
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0624
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0379
2009 Protein NOV homolog NOV 0.0379
1949 Carboxypeptidase E CPE 0.0379
3848 Neuroendocrine convertase 1 PCSK1 0.0379
3847 Neuroendocrine convertase 2 PCSK2 0.0379
3850 Synaptotagmin-like protein 4 SYTL4 0.0379
3846 Retinoblastoma-associated protein RB1 0.0379
2155 Insulin-degrading enzyme IDE 0.0334
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0319
1243 Cathepsin D CTSD 0.0316
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.021
3794 Osmolarity sensor protein envZ envZ 0.0064
5644 Sensor protein phoQ phoQ 0.0064
5641 Rod shape-determining protein MreB TM_0588 0.0064
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0064
5645 DNA topoisomerase 4 subunit B parE 0.0064
6227 DNA topoisomerase 4 subunit B parE 0.0064
5649 Potassium-transporting ATPase B chain kdpB 0.0064
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0064
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0064
5643 General secretion pathway protein E epsE 0.0064
5642 Chaperone clpB clpB 0.0064
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0056
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0056
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0056
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0056
5302 TrwB trwB 0.0056
2282 Protein recA recA 0.0056
2315 Protein recA recA 0.0056
2332 Protein recA recA 0.0056
5263 Protein recA recA 0.0056
2397 Dihydroxyacetone kinase dhaK 0.0056
4751 Mitogen-activated protein kinase 12 MAPK12 0.0056
5646 Galactokinase GALK1 0.0056
2852 DNA mismatch repair protein mutL mutL 0.0056
740 Argininosuccinate synthase ASS1 0.0056
865 Argininosuccinate synthase ASS1 0.0056
2680 Argininosuccinate synthase argG 0.0056
3194 Argininosuccinate synthase argG 0.0056
5265 FtsH ftsH 0.0056
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0051
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0051
3231 Death-associated protein kinase 1 DAPK1 0.0051
5312 Kinesin-like protein KIF1A KIF1A 0.0051
887 DNA gyrase subunit B gyrB 0.0049
4150 DNA gyrase subunit B gyrB 0.0049
6225 DNA gyrase subunit B gyrB 0.0049
936 Ephrin type-A receptor 2 EPHA2 0.0049
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0048
2371 Pantothenate kinase coaA 0.0048
825 Arsenical pump-driving ATPase ASNA1 0.0048
3435 Arsenical pump-driving ATPase arsA 0.0048
2892 Acetylglutamate kinase argB 0.0048
3550 Acetylglutamate kinase argB 0.0048
2615 Chemotaxis protein cheA cheA 0.0048
1881 Hexokinase-1 HK1 0.0048
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0047
2727 S-adenosylmethionine synthetase metK 0.0046
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0045
4878 Glycoprotein hormones alpha chain CGA 0.0045
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0044
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0044
1072 Granzyme B GZMB 0.0044
4877 Beta-mannanase man 0.0044
4852 Reticulon-4 receptor RTN4R 0.0044
4850 Beta-2-glycoprotein 1 APOH 0.0044
4880 Membrane cofactor protein CD46 0.0044
4856 CD209 antigen CD209 0.0044
442 Envelope glycoprotein gp41 0.0044
4859 Envelope glycoprotein env 0.0044
4889 Ig epsilon chain C region IGHE 0.0044
4189 Alpha-galactosidase A GLA 0.0044
4869 Major capsid protein A430L 0.0044
757 Fusion glycoprotein F0 F 0.0044
4875 Fusion glycoprotein F0 F 0.0044
4721 Beta-1,4-mannanase manA 0.0044
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0044
1354 Beta-glucuronidase GUSB 0.0044
3352 Structural polyprotein Not Available 0.0044
3628 Structural polyprotein Not Available 0.0044
4892 Structural polyprotein Not Available 0.0044
4845 ADAM 33 ADAM33 0.0044
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0044
4192 DNA topoisomerase 2-beta TOP2B 0.0043
207 Glutathione synthetase GSS 0.0042
5269 Glutathione synthetase gshB 0.0042
2251 Thymidylate kinase tmk 0.0041
2254 Thymidylate kinase DTYMK 0.0041
3522 Thymidylate kinase tmk 0.0041
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.004
1184 Interferon beta IFNB1 0.0039
793 T-cell surface antigen CD2 CD2 0.0039
6858 Inactive carboxylesterase 4 CES1P1 0.0039
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0039
1379 Interleukin-12 subunit beta IL12B 0.0039
4861 Interleukin-6 receptor alpha chain IL6R 0.0039
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0039
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0039
4890 Hemagglutinin HA 0.0039
6566 Hemagglutinin Not Available 0.0039
3837 Cytokine receptor common beta chain CSF2RB 0.0039
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0038
3822 Actin, alpha skeletal muscle ACTA1 0.0038
1836 Mitogen-activated protein kinase 10 MAPK10 0.0036
554 Low-density lipoprotein receptor LDLR 0.0036
3444 Cyanovirin-N Not Available 0.0036
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0036
1859 Prostatic acid phosphatase ACPP 0.0036
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0036
3140 Hemagglutinin-neuraminidase HN 0.0036
3609 Hemagglutinin-neuraminidase HN 0.0036
2297 Genome polyprotein Not Available 0.0036
2322 Genome polyprotein Not Available 0.0036
2694 Genome polyprotein Not Available 0.0036
2719 Genome polyprotein Not Available 0.0036
2860 Genome polyprotein Not Available 0.0036
2928 Genome polyprotein Not Available 0.0036
3160 Genome polyprotein Not Available 0.0036
3260 Genome polyprotein Not Available 0.0036
4783 Genome polyprotein Not Available 0.0036
5726 Genome polyprotein Not Available 0.0036
5779 Genome polyprotein Not Available 0.0036
5867 Genome polyprotein Not Available 0.0036
6253 Genome polyprotein Not Available 0.0036
6301 Genome polyprotein Not Available 0.0036
6380 Genome polyprotein Not Available 0.0036
6381 Genome polyprotein Not Available 0.0036
6437 Genome polyprotein Not Available 0.0036
6520 Genome polyprotein Not Available 0.0036
6521 Genome polyprotein Not Available 0.0036
6652 Genome polyprotein Not Available 0.0036
6734 Genome polyprotein Not Available 0.0036
6735 Genome polyprotein Not Available 0.0036
6736 Genome polyprotein Not Available 0.0036
6737 Genome polyprotein Not Available 0.0036
6738 Genome polyprotein Not Available 0.0036
6739 Genome polyprotein Not Available 0.0036
6744 Genome polyprotein Not Available 0.0036
6748 Genome polyprotein Not Available 0.0036
6894 Genome polyprotein Not Available 0.0036
6898 Genome polyprotein Not Available 0.0036
1721 Glycogen synthase kinase-3 beta GSK3B 0.0035
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0035
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0034
852 Heparin cofactor 2 SERPIND1 0.0034
2236 Casein kinase II subunit alpha CSNK2A1 0.0034
4666 Fucose-binding lectin PA-IIL lecB 0.0034
4787 Envelope glycoprotein gp160 env 0.0034
4820 Envelope glycoprotein gp160 env 0.0034
5727 Envelope glycoprotein gp160 env 0.0034
2372 Bifunctional tail protein 9 0.0034
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0032
3480 Mannan endo-1,4-beta-mannosidase manA 0.0031
64 Neuraminidase NA 0.0031
641 Neuraminidase NA 0.0031
2676 Neuraminidase NA 0.0031
3026 Neuraminidase NA 0.0031
3519 Neuraminidase NA 0.0031
6007 Neuraminidase NA 0.0031
595 Fibrinogen alpha chain FGA 0.003
1439 Lactotransferrin LTF 0.003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.003
2430 Chondroitinase B cslB 0.0029
6307 Ig gamma-2 chain C region IGHG2 0.0028
2581 Chondroitinase AC cslA 0.0028
6847 Lactase-phlorizin hydrolase LCT 0.0028
6500 Phospholipase A2 PLA2G1B 0.0027
309 Antithrombin-III SERPINC1 0.0027
2207 Rhodopsin RHO 0.0026
3814 Complement C1r subcomponent C1R 0.0025
4785 Ig gamma-1 chain C region IGHG1 0.0023
76 Nitric-oxide synthase, brain NOS1 0.0023
4604 Liver carboxylesterase 1 CES1 0.0022
952 Dipeptidyl peptidase 4 DPP4 0.002
3923 Cholinesterase BCHE 0.0017
20 Prostaglandin G/H synthase 1 PTGS1 0.0016
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