Identification | |
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Name | Bafilomycin A1 |
Accession Number | DB06733 |
Type | small molecule |
Description | The bafilomycins are a family of toxic macrolide antibiotic derived from Streptomyces griseus. These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase). The most used bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis. [Wikipedia] |
Structure |
|
Categories (*) | |
Molecular Weight | Not Available |
Groups | experimental |
Monoisotopic Weight | Not Available |
Pharmacology | |
Indication | Not Available |
Mechanism of action | The bafilomycins are a family of toxic macrolide antibiotic derived from Streptomyces griseus. These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase). |
Absorption | Not Available |
Protein binding | Not Available |
Biotransformation | Not Available |
Route of elimination | Not Available |
Toxicity | Not Available |
Affected organisms | Not Available |
Interactions | |
Drug Interactions | Not Available |
Food Interactions | Not Available |
V-type proton ATPase catalytic subunit A | |
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Name | V-type proton ATPase catalytic subunit A |
Gene Name | ATP6V1A |
Pharmacological action | yes |
Actions | inhibitor |
References |
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DTHybrid score | 1.2272 |
Id | Partner name | Gene Name | Score |
---|---|---|---|
6055 | Receptor-type tyrosine-protein phosphatase S | PTPRS | 0.2659 |
1376 | Tyrosine-protein phosphatase non-receptor type 4 | PTPN4 | 0.0871 |
6056 | Receptor-type tyrosine-protein phosphatase epsilon | PTPRE | 0.0871 |
687 | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 | 0.0812 |
853 | Farnesyl pyrophosphate synthetase | FDPS | 0.0483 |