Identification | |||||||||||
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Name | Aluminum hydroxide | ||||||||||
Accession Number | DB06723 | ||||||||||
Type | small molecule | ||||||||||
Description | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | ||||||||||
Structure |
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Categories (*) | |||||||||||
Molecular Weight | 78.0036 | ||||||||||
Groups | approved | ||||||||||
Monoisotopic Weight | 77.989757403 | ||||||||||
Pharmacology | |||||||||||
Indication | For relief of heartburn and acid indigestion. | ||||||||||
Mechanism of action | Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins. | ||||||||||
Absorption | Approximately 17-30% of the aluminum chloride formed is absorbed. | ||||||||||
Protein binding | Not Available | ||||||||||
Biotransformation | Not metabolized. | ||||||||||
Route of elimination | Absorbed aluminum chloride is rapidly eliminated by the kidneys in patients with normal renal function. | ||||||||||
Toxicity | Not Available | ||||||||||
Affected organisms | Not Available | ||||||||||
Interactions | |||||||||||
Drug Interactions |
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Food Interactions | Not Available |
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