DT-Web

DB06707 - Levonordefrin


Identification
Name Levonordefrin
Accession Number DB06707
Type small molecule
Description Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 183.2044
Groups approved
Monoisotopic Weight 183.089543287
Pharmacology
Indication Used as a topical nasal decongestant and vasoconstrictor in dentistry.
Mechanism of action It is designed to mimic the molecular shape of adrenaline. It binds to alpha-adrenergic receptors in the nasal mucosa. Here it can, therefore, cause vasoconstriction
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Desvenlafaxine Desvenlafaxine may increase the tachycardic and vasopressor effects of levonordefrin. Consider alternate therapy or monitor for increased sympathomimetic effects, such as increased blood pressure, chest pain and headache.
Food Interactions Not Available

Targets


Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action yes
Actions agonist
References
  • Jastak JT, Yagiela JA: Vasoconstrictors and local anesthesia: a review and rationale for use. J Am Dent Assoc. 1983 Oct;107(4):623-30. - Pubmed
  • Hersh EV, Giannakopoulos H: Beta-adrenergic blocking agents and dental vasoconstrictors. Dent Clin North Am. 2010 Oct;54(4):687-96. - Pubmed
  • Yang HT, Endoh M: (+/-)-tamsulosin, an alpha 1A-adrenoceptor antagonist, inhibits the positive inotropic effect but not the accumulation of inositol phosphates in rabbit heart. Eur J Pharmacol. 1996 Oct 3;312(3):281-91. - Pubmed
  • Haenisch B, Walstab J, Herberhold S, Bootz F, Tschaikin M, Ramseger R, Bonisch H: Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39. - Pubmed
DTHybrid score 0.3072
Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action unknown
Actions inhibitor
References
  • Habecker BA, Willison BD, Shi X, Woodward WR: Chronic depolarization stimulates norepinephrine transporter expression via catecholamines. J Neurochem. 2006 May;97(4):1044-51. Epub 2006 Mar 29. - Pubmed
  • Bonisch H, Bruss M: The norepinephrine transporter in physiology and disease. Handb Exp Pharmacol. 2006;(175):485-524. - Pubmed
  • Mandela P, Ordway GA: KCl stimulation increases norepinephrine transporter function in PC12 cells. J Neurochem. 2006 Sep;98(5):1521-30. Epub 2006 Jul 31. - Pubmed
  • Gutman DA, Owens MJ: Serotonin and norepinephrine transporter binding profile of SSRIs. Essent Psychopharmacol. 2006;7(1):35-41. - Pubmed
  • Ksiazek P, Buraczynska K, Buraczynska M: Norepinephrine transporter gene (NET) polymorphism in patients with type 2 diabetes. Kidney Blood Press Res. 2006;29(6):338-43. Epub 2006 Nov 23. - Pubmed
DTHybrid score 0.3503

Predictions


Id Partner name Gene Name Score
824 Sodium-dependent serotonin transporter SLC6A4 0.1332
713 Sodium-dependent dopamine transporter SLC6A3 0.1191
632 Alpha-1B adrenergic receptor ADRA1B 0.0966
318 Alpha-2A adrenergic receptor ADRA2A 0.0966
4119 Cytochrome P450 2D6 CYP2D6 0.0945
4512 Cytochrome P450 3A4 CYP3A4 0.0686
789 Alpha-1D adrenergic receptor ADRA1D 0.0555
502 5-hydroxytryptamine 2A receptor HTR2A 0.0525
131 Synaptic vesicular amine transporter SLC18A2 0.0489
1588 Multidrug resistance protein 1 ABCB1 0.0486
492 Histamine H1 receptor HRH1 0.0411
831 D(2) dopamine receptor DRD2 0.0408
4200 Cytochrome P450 1A2 CYP1A2 0.0348
23 D(1A) dopamine receptor DRD1 0.0326
629 Alpha-2B adrenergic receptor ADRA2B 0.0313
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0305
766 Beta-2 adrenergic receptor ADRB2 0.0301
193 Beta-1 adrenergic receptor ADRB1 0.0284
3941 Amine oxidase [flavin-containing] A MAOA 0.0277
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0274
590 5-hydroxytryptamine 2C receptor HTR2C 0.0265
320 5-hydroxytryptamine 1A receptor HTR1A 0.0262
6016 Cytochrome P450 2C19 CYP2C19 0.0261
378 Alpha-2C adrenergic receptor ADRA2C 0.0256
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0208
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0203
6030 Cytochrome P450 2B6 CYP2B6 0.0201
4757 Cytochrome P450 2C9 CYP2C9 0.02
51 Muscarinic acetylcholine receptor M3 CHRM3 0.02
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0191
3939 Amine oxidase [flavin-containing] B MAOB 0.0167
6013 Cytochrome P450 2E1 CYP2E1 0.015
6145 Solute carrier family 22 member 1 SLC22A1 0.0144
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0142
1636 Trace amine-associated receptor 1 TAAR1 0.0127
6144 Solute carrier family 22 member 2 SLC22A2 0.0117
432 D(4) dopamine receptor DRD4 0.0117
3923 Cholinesterase BCHE 0.0117
4118 Cytochrome P450 3A5 CYP3A5 0.0116
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0111
1517 Beta-3 adrenergic receptor ADRB3 0.0103
436 5-hydroxytryptamine 2B receptor HTR2B 0.0103
6147 Solute carrier family 22 member 3 SLC22A3 0.0102
725 5-hydroxytryptamine 1D receptor HTR1D 0.0099
6107 Cytochrome P450 3A7 CYP3A7 0.0098
638 D(3) dopamine receptor DRD3 0.0091
828 Phenylalanine-4-hydroxylase PAH 0.0089
3109 Phenylalanine-4-hydroxylase phhA 0.0089
587 Serum albumin ALB 0.0087
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0086
4924 Cytochrome P450 2C8 CYP2C8 0.0086
885 5-hydroxytryptamine 1B receptor HTR1B 0.0085
716 5-hydroxytryptamine 7 receptor HTR7 0.0083
163 D(1B) dopamine receptor DRD5 0.0081
1256 5-hydroxytryptamine 6 receptor HTR6 0.008
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0078
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0078
474 Acetylcholinesterase ACHE 0.0077
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0074
6432 Transporter snf 0.0071
6024 Cytochrome P450 1A1 CYP1A1 0.0069
118 Organic cation/carnitine transporter 2 SLC22A5 0.0061
465 Calmodulin CALM1 0.0058
467 Delta-type opioid receptor OPRD1 0.0055
696 Kappa-type opioid receptor OPRK1 0.0055
341 5-hydroxytryptamine 3 receptor HTR3A 0.0053
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0048
124 Histamine H2 receptor HRH2 0.0047
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0046
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0046
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0045
2981 Phospholipase A2, membrane associated PLA2G2A 0.0044
1757 Myeloperoxidase MPO 0.0044
6138 Multidrug resistance protein 3 ABCB4 0.0043
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0042
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0042
6182 Cytochrome P450 2J2 CYP2J2 0.0041
847 Mu-type opioid receptor OPRM1 0.004
482 Glycine receptor subunit alpha-1 GLRA1 0.004
1656 CYP2B protein CYP2B 0.004
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0038
3426 Glutamine synthetase glnA 0.0037
3987 Glutamine synthetase GLUL 0.0037
528 5-hydroxytryptamine 1E receptor HTR1E 0.0037
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0036
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0036
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0036
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0036
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0035
6859 Protein S100-A4 S100A4 0.0035
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0034
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0033
5718 Cytochrome P450 2A6 CYP2A6 0.0032
6151 Monocarboxylate transporter 10 SLC16A10 0.003
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.003
6106 Cytochrome P450 2C18 CYP2C18 0.003
4120 NADPH--cytochrome P450 reductase POR 0.003
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0029
1360 Sphingomyelin phosphodiesterase SMPD1 0.0029
833 Organic cation/carnitine transporter 1 SLC22A4 0.0029
3947 Xanthine dehydrogenase/oxidase XDH 0.0028
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0028
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0027
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0026
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0024
20 Prostaglandin G/H synthase 1 PTGS1 0.0023
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0023
904 Glutathione S-transferase P GSTP1 0.002
1618 High affinity nerve growth factor receptor NTRK1 0.002
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0019
1374 Natriuretic peptides B NPPB 0.0019
1827 Gap junction alpha-1 protein GJA1 0.0019
1908 Vascular cell adhesion protein 1 VCAM1 0.0019
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0017
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0017
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0017
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0016
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0016
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0015
183 Vascular endothelial growth factor A VEGFA 0.0014
233 Potassium channel subfamily K member 2 KCNK2 0.0014
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0012
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0012
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0012
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0011
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0011
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0011
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0011
158 Sodium channel protein type 1 subunit alpha SCN1A 0.001
776 Bile salt export pump ABCB11 0.001
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0009
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0008
164 Histamine H4 receptor HRH4 0.0007
1898 Cytochrome P450 1B1 CYP1B1 0.0004
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