DT-Web

DB05265 - Ecabet


Identification
Name Ecabet
Accession Number DB05265
Type small molecule
Description Ecabet is a prescription eye drop for the treatment of dry eye syndrome. Ecabet represents a new class of molecules that increases the quantity and quality of mucin produced by conjunctival goblet cells and corneal epithelia. Mucin is a glycoprotein component of tear film that lubricates while retarding moisture loss from tear evaporation. Ecabet is currently marketed in Japan as an oral agent for treatment of gastric ulcers and gastritis.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 380.498
Groups approved
Monoisotopic Weight 380.165744696
Pharmacology
Indication For the treatment of reflux oesophagitis and peptic ulcer disease.
Mechanism of action Ecabet reduces the survival of H. pylori in the stomach and inhibits pepsin activity in the gastric juice of experimental animals. Here we have investigated the effects of ecabet on some of the factors involved in the dynamics of the mucosal barrier, i.e. pepsins and mucins. Pepsin, acid and Helicobacter pylori are major factors in the pathophysiology of peptic ulcer disease and reflux oesophagitis. Ecabet also acts as an inhibitor of H. pylori NADPH oxidase as well as urease. Inhibition of these enzymes prevents bacterial adhesion to gastric mucosa.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


NADPH oxidase organizer 1
Name NADPH oxidase organizer 1
Gene Name NOXO1
Pharmacological action yes
Actions antagonist
References
  • Kusumoto K, Kawahara T, Kuwano Y, Teshima-Kondo S, Morita K, Kishi K, Rokutan K: Ecabet sodium inhibits Helicobacter pylori lipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G300-7. Epub 2004 Sep 30. - Pubmed
DTHybrid score 1.3884
Urease alpha subunit
Name Urease alpha subunit
Gene Name ureC
Pharmacological action yes
Actions inhibitor
References
  • Koizumi W, Tanabe S, Imaizumi H, Kida M, Ohida M, Koshida Y, Mitomi H, Hosaka Y, Nagaba S, Sasaki T, Higuchi K, Saigenji K: Inhibition of peptic ulcer relapse by ranitidine and ecabet independently of eradication of Helicobacter pylori: a prospective, controlled study versus ranitidine. Hepatogastroenterology. 2003 Mar-Apr;50(50):577-81. - Pubmed
  • Takahashi S, Tanaka A: [Ecabet sodium] Nippon Rinsho. 2002 Feb;60 Suppl 2:711-6. - Pubmed
  • Adachi K, Ishihara S, Hashimoto T, Hirakawa K, Ishimura N, Niigaki M, Kaji T, Kawamura A, Sato H, Fujishiro H, Hattori S, Watanabe M, Kinoshita Y: Efficacy of ecabet sodium for Helicobacter pylori eradication triple therapy in comparison with a lansoprazole-based regimen. Aliment Pharmacol Ther. 2001 Aug;15(8):1187-91. - Pubmed
DTHybrid score 1.4138

Predictions


Id Partner name Gene Name Score
2203 Macrophage metalloelastase MMP12 0.2265
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