DT-Web

DB05246 - Methsuximide


Identification
Name Methsuximide
Accession Number DB05246
Type small molecule
Description Mesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 203.2371
Groups approved
Monoisotopic Weight 203.094628665
Pharmacology
Indication For the control of absence (petit mal) seizures that are refractory to other drugs.
Mechanism of action Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression. Levels greater than 40 µg/mL have caused toxicity and coma has been seen at levels of 150 µg/mL.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Lamotrigine Methsuximide decreases the effect of lamotrigine
Ticlopidine Ticlopidine may decrease the metabolism and clearance of Methsuximide. Consider alternate therapy or monitor for adverse/toxic effects of Methsuximide if Ticlopidine is initiated, discontinued or dose changed.
Triprolidine The CNS depressants, Triprolidine and Methsuximide, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Food Interactions
  • Avoid alcohol
  • Take with food

Targets


Voltage-dependent T-type calcium channel subunit alpha-1G
Name Voltage-dependent T-type calcium channel subunit alpha-1G
Gene Name CACNA1G
Pharmacological action yes
Actions inhibitor
References
  • Gomora JC, Daud AN, Weiergraber M, Perez-Reyes E: Block of cloned human T-type calcium channels by succinimide antiepileptic drugs. Mol Pharmacol. 2001 Nov;60(5):1121-32. - Pubmed
  • Coulter DA, Huguenard JR, Prince DA: Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol. 1989 Jun;25(6):582-93. - Pubmed
  • Wang G, Thompson SM: Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions. J Neurosci. 2008 Nov 12;28(46):11959-69. - Pubmed
  • Matthews EA, Dickenson AH: Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats. Eur J Pharmacol. 2001 Mar;415(2-3):141-9. - Pubmed
DTHybrid score 0.2117

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2154

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.1072
4512 Cytochrome P450 3A4 CYP3A4 0.0995
4119 Cytochrome P450 2D6 CYP2D6 0.0695
4200 Cytochrome P450 1A2 CYP1A2 0.0633
4924 Cytochrome P450 2C8 CYP2C8 0.0571
6013 Cytochrome P450 2E1 CYP2E1 0.0561
4118 Cytochrome P450 3A5 CYP3A5 0.0513
6030 Cytochrome P450 2B6 CYP2B6 0.0475
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.043
6107 Cytochrome P450 3A7 CYP3A7 0.0415
1588 Multidrug resistance protein 1 ABCB1 0.0394
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0339
6024 Cytochrome P450 1A1 CYP1A1 0.0327
5718 Cytochrome P450 2A6 CYP2A6 0.0321
6031 Cytochrome P450 3A43 CYP3A43 0.0253
492 Histamine H1 receptor HRH1 0.0233
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0232
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.02
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0195
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0195
6106 Cytochrome P450 2C18 CYP2C18 0.0184
587 Serum albumin ALB 0.0165
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0163
20 Prostaglandin G/H synthase 1 PTGS1 0.0162
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0152
824 Sodium-dependent serotonin transporter SLC6A4 0.0134
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0127
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0127
465 Calmodulin CALM1 0.0127
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0123
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0114
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0107
831 D(2) dopamine receptor DRD2 0.0107
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0103
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0096
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0095
260 Cytochrome P450 51 ERG11 0.0092
761 Cytochrome P450 51 ERG11 0.0092
3163 Cytochrome P450 51 cyp51 0.0092
3941 Amine oxidase [flavin-containing] A MAOA 0.0091
6145 Solute carrier family 22 member 1 SLC22A1 0.0086
1729 Solute carrier family 22 member 6 SLC22A6 0.0082
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0081
3939 Amine oxidase [flavin-containing] B MAOB 0.008
1181 Alpha-1-acid glycoprotein 1 ORM1 0.008
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
6144 Solute carrier family 22 member 2 SLC22A2 0.0077
862 Multidrug resistance-associated protein 1 ABCC1 0.0077
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0074
6133 Sodium channel subunit beta-2 SCN2B 0.0071
6135 Sodium channel subunit beta-4 SCN4B 0.0071
6134 Sodium channel subunit beta-3 SCN3B 0.0071
6132 Sodium channel subunit beta-1 SCN1B 0.0071
6127 Carbonic anhydrase-related protein CA8 0.0071
6129 Carbonic anhydrase-related protein 11 CA11 0.0071
6128 Carbonic anhydrase-related protein 10 CA10 0.0071
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.007
731 HIV-1 protease HIV-1 protease 0.007
3811 Cytochrome P450 19A1 CYP19A1 0.0069
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0069
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0068
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0067
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0066
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0064
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0064
6130 Carbonic anhydrase 13 CA13 0.0063
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0063
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0063
776 Bile salt export pump ABCB11 0.0063
713 Sodium-dependent dopamine transporter SLC6A3 0.0063
290 Prostaglandin G/H synthase 2 PTGS2 0.0062
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0061
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0061
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0061
766 Beta-2 adrenergic receptor ADRB2 0.006
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.006
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0059
6131 Carbonic anhydrase 14 CA14 0.0059
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0059
592 Carbonic anhydrase 4 CA4 0.0058
6126 Carbonic anhydrase 7 CA7 0.0058
2164 Multidrug resistance-associated protein 4 ABCC4 0.0057
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0057
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0057
6122 Carbonic anhydrase 3 CA3 0.0056
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0054
1898 Cytochrome P450 1B1 CYP1B1 0.0052
502 5-hydroxytryptamine 2A receptor HTR2A 0.0052
118 Organic cation/carnitine transporter 2 SLC22A5 0.0052
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0052
556 Alpha-1A adrenergic receptor ADRA1A 0.0051
3007 Carbonic anhydrase 12 CA12 0.005
4205 Carbonic anhydrase 9 CA9 0.005
6142 Solute carrier family 22 member 8 SLC22A8 0.0049
146 Androgen receptor AR 0.0048
833 Organic cation/carnitine transporter 1 SLC22A4 0.0047
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0046
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0046
468 Cytochrome P450 4A11 CYP4A11 0.0046
6148 Multidrug resistance-associated protein 7 ABCC10 0.0045
357 Carbonic anhydrase 2 CA2 0.0045
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0044
295 Carbonic anhydrase 1 CA1 0.0044
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0044
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0043
632 Alpha-1B adrenergic receptor ADRA1B 0.0043
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0043
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0042
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0042
23 D(1A) dopamine receptor DRD1 0.0042
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0042
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.004
124 Histamine H2 receptor HRH2 0.004
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.004
6143 Solute carrier family 22 member 7 SLC22A7 0.004
6020 Aldehyde oxidase AOX1 0.0039
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0038
122 P2Y purinoceptor 12 P2RY12 0.0038
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0038
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0037
193 Beta-1 adrenergic receptor ADRB1 0.0037
590 5-hydroxytryptamine 2C receptor HTR2C 0.0037
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0036
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0036
320 5-hydroxytryptamine 1A receptor HTR1A 0.0035
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0035
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0035
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0035
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0033
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0033
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0033
362 Melatonin receptor type 1B MTNR1B 0.0032
571 Melatonin receptor type 1A MTNR1A 0.0032
6182 Cytochrome P450 2J2 CYP2J2 0.0032
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0031
341 5-hydroxytryptamine 3 receptor HTR3A 0.003
789 Alpha-1D adrenergic receptor ADRA1D 0.003
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0029
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0029
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0029
817 DNA topoisomerase 2-alpha TOP2A 0.0028
318 Alpha-2A adrenergic receptor ADRA2A 0.0028
49 Endothelin B receptor EDNRB 0.0027
777 Tumor necrosis factor TNF 0.0026
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0026
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0026
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0026
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0026
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0026
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0026
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0026
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0026
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0026
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0026
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0026
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0026
885 5-hydroxytryptamine 1B receptor HTR1B 0.0026
136 Estrogen receptor ESR1 0.0025
85 Growth hormone receptor GHR 0.0025
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0025
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0025
578 Endothelin-1 receptor EDNRA 0.0025
6147 Solute carrier family 22 member 3 SLC22A3 0.0024
921 Glutamate receptor 2 GRIA2 0.0024
183 Vascular endothelial growth factor A VEGFA 0.0023
844 Epidermal growth factor receptor EGFR 0.0023
638 D(3) dopamine receptor DRD3 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
2539 Tubulin alpha-1 chain TUBA4A 0.0022
70 Type-1 angiotensin II receptor AGTR1 0.0022
373 Transthyretin TTR 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
6136 Multidrug resistance-associated protein 5 ABCC5 0.0021
5300 Antigen peptide transporter 1 TAP1 0.0021
725 5-hydroxytryptamine 1D receptor HTR1D 0.0021
696 Kappa-type opioid receptor OPRK1 0.0021
1024 Solute carrier family 22 member 11 SLC22A11 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6137 Multidrug resistance-associated protein 6 ABCC6 0.002
161 Tubulin beta chain TUBB 0.002
312 Tubulin beta chain TUB2 0.002
6220 Aryl hydrocarbon receptor AHR 0.002
6014 Cytochrome P450 2A13 CYP2A13 0.0019
467 Delta-type opioid receptor OPRD1 0.0019
1656 CYP2B protein CYP2B 0.0019
4120 NADPH--cytochrome P450 reductase POR 0.0019
558 Solute carrier family 12 member 1 SLC12A1 0.0018
1253 Interferon gamma IFNG 0.0018
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0018
380 Cytochrome P450 17A1 CYP17A1 0.0018
1757 Myeloperoxidase MPO 0.0018
1010 Cytochrome P450 51A1 CYP51A1 0.0018
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0018
756 Sex hormone-binding globulin SHBG 0.0018
6141 Sodium/bile acid cotransporter SLC10A1 0.0018
427 Substance-P receptor TACR1 0.0018
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0017
6102 Arylamine N-acetyltransferase 2 NAT2 0.0017
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0017
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
528 5-hydroxytryptamine 1E receptor HTR1E 0.0017
891 Dihydropteroate synthase folP 0.0017
5359 Dihydropteroate synthase folP 0.0017
7175 Dihydropteroate synthase sulI 0.0017
633 Penicillin-binding proteins 1A/1B pbpA 0.0016
6432 Transporter snf 0.0016
847 Mu-type opioid receptor OPRM1 0.0016
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0016
432 D(4) dopamine receptor DRD4 0.0016
436 5-hydroxytryptamine 2B receptor HTR2B 0.0016
823 Fibroblast growth factor receptor 2 FGFR2 0.0015
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0015
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0015
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0015
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0015
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0015
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0015
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0015
4604 Liver carboxylesterase 1 CES1 0.0014
3923 Cholinesterase BCHE 0.0014
716 5-hydroxytryptamine 7 receptor HTR7 0.0014
629 Alpha-2B adrenergic receptor ADRA2B 0.0014
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0014
614 Progesterone receptor PGR 0.0014
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0014
65 Matrix metalloproteinase-9 Not Available 0.0014
1618 High affinity nerve growth factor receptor NTRK1 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0014
4311 tRNA TRDMT1 0.0013
4325 tRNA trmD 0.0013
4328 tRNA trmD 0.0013
228 Beta platelet-derived growth factor receptor PDGFRB 0.0013
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0013
106 Cannabinoid receptor 2 CNR2 0.0013
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0013
818 50S ribosomal protein L10 rplJ 0.0013
518 Peroxidase/catalase T katG 0.0013
6174 50S ribosomal protein L32 rpmF 0.0013
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0013
4238 50S ribosomal protein L4 rplD 0.0013
5578 50S ribosomal protein L4 rplD 0.0013
6173 50S ribosomal protein L4 rplD 0.0013
6219 50S ribosomal protein L4 rplD 0.0013
1196 Complement decay-accelerating factor CD55 0.0013
3426 Glutamine synthetase glnA 0.0013
3987 Glutamine synthetase GLUL 0.0013
871 Glucocorticoid receptor NR3C1 0.0013
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
504 Mast/stem cell growth factor receptor KIT 0.0012
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0012
68 Cannabinoid receptor 1 CNR1 0.0012
563 Thyroid peroxidase TPO 0.0012
811 Translocator protein TSPO 0.0012
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0012
634 Squalene monooxygenase SQLE 0.0012
7196 Squalene monooxygenase ERG1 0.0012
2808 Chloramphenicol acetyltransferase 3 cat3 0.0011
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0011
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0011
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0011
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0011
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.001
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.001
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.001
3601 Dihydropteroate synthase 1 folP1 0.001
3807 Dihydropteroate synthase 1 folP1 0.001
3808 Dihydropteroate synthase 2 folP2 0.001
2417 Chloramphenicol acetyltransferase cat 0.001
3278 Chloramphenicol acetyltransferase cat 0.001
2810 Dr hemagglutinin structural subunit draA 0.001
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.001
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.001
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.001
365 Dihydrofolate reductase DHFR 0.001
2381 Dihydrofolate reductase DFR1 0.001
2833 Dihydrofolate reductase Not Available 0.001
2931 Dihydrofolate reductase folA 0.001
3544 Dihydrofolate reductase folA 0.001
3682 Dihydrofolate reductase folA 0.001
6642 Dihydrofolate reductase folA 0.001
6756 Dihydrofolate reductase dfrA 0.001
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.001
163 D(1B) dopamine receptor DRD5 0.001
3913 Glutamic acid decarboxylase GAD65 0.001
581 Cytochrome P450 2R1 CYP2R1 0.001
378 Alpha-2C adrenergic receptor ADRA2C 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.001
950 Alpha platelet-derived growth factor receptor PDGFRA 0.001
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0009
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0009
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0009
3830 Calreticulin CALR 0.0009
1992 Vitamin D-binding protein GC 0.0009
319 Opioid receptor, sigma 1 OPRS1 0.0009
1483 Membrane copper amine oxidase AOC3 0.0009
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0009
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0009
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0009
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0009
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0009
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0009
6034 Hydroxyindole O-methyltransferase ASMT 0.0009
6035 Nuclear receptor ROR-beta RORB 0.0009
6036 Eosinophil peroxidase EPX 0.0009
1256 5-hydroxytryptamine 6 receptor HTR6 0.0009
976 Platelet glycoprotein IX GP9 0.0009
1630 Integrin beta-2 ITGB2 0.0008
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0008
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0008
4102 Proteasome subunit beta type 5 PSMB5 0.0008
4101 Proteasome subunit beta type 1 PSMB1 0.0008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0008
4217 Telomerase reverse transcriptase TERT 0.0008
735 Alanine aminotransferase 1 GPT 0.0008
3904 Alanine aminotransferase 2 GPT2 0.0008
511 5-hydroxytryptamine 1F receptor HTR1F 0.0008
94 5-hydroxytryptamine 4 receptor HTR4 0.0008
6146 High affinity copper uptake protein 1 SLC31A1 0.0008
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0008
6085 Fatty acid-binding protein, intestinal FABP2 0.0008
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0008
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0008
239 Coagulation factor X F10 0.0008
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0008
174 Sigma 1-type opioid receptor SIGMAR1 0.0008
251 Alcohol dehydrogenase 1A ADH1A 0.0008
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0007
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0007
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0007
820 Glycine receptor subunit alpha-2 GLRA2 0.0007
6044 Serum paraoxonase/lactonase 3 PON3 0.0007
2981 Phospholipase A2, membrane associated PLA2G2A 0.0007
2021 Thrombomodulin THBD 0.0007
1517 Beta-3 adrenergic receptor ADRB3 0.0007
33 Cystine/glutamate transporter SLC7A11 0.0007
444 Alcohol dehydrogenase 1B ADH1B 0.0007
856 Vitamin D3 receptor VDR 0.0007
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0007
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0006
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0006
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0006
572 Integrin alpha-L ITGAL 0.0006
904 Glutathione S-transferase P GSTP1 0.0006
5798 Mitogen-activated protein kinase 11 MAPK11 0.0006
267 Plasminogen activator inhibitor 1 SERPINE1 0.0006
2320 Thymidine kinase, cytosolic TK1 0.0006
1864 RET proto-oncogene RET 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
482 Glycine receptor subunit alpha-1 GLRA1 0.0006
738 Monocarboxylate transporter 1 SLC16A1 0.0006
4122 Histone deacetylase 2 HDAC2 0.0006
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0006
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0006
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0006
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0006
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0006
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0006
153 Dopamine beta-hydroxylase DBH 0.0006
869 Estrogen receptor beta ESR2 0.0006
7 Nitric oxide synthase, inducible NOS2 0.0006
517 Alcohol dehydrogenase 1C ADH1C 0.0006
6218 Pannexin-1 PANX1 0.0006
5934 Cytochrome P450 26A1 CYP26A1 0.0006
6221 Steroid hormone receptor ERR1 ESRRA 0.0006
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0006
1039 Histone deacetylase 9 HDAC9 0.0006
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0005
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0005
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0005
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0005
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0005
6042 Prostaglandin reductase 2 PTGR2 0.0005
936 Ephrin type-A receptor 2 EPHA2 0.0005
165 FL cytokine receptor FLT3 0.0005
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0005
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0005
84 Nuclear receptor 0B1 NR0B1 0.0005
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0005
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0005
5787 Angiopoietin-1 receptor TEK 0.0005
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0005
1192 Sulfotransferase 1A1 SULT1A1 0.0005
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0005
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0005
3810 Catechol O-methyltransferase COMT 0.0005
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0005
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0005
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0005
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0005
1792 Tissue-type plasminogen activator PLAT 0.0005
273 Apoptosis regulator Bcl-2 BCL2 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
6043 Putative G-protein coupled receptor 44 GPR44 0.0005
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0005
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0004
469 Annexin A1 ANXA1 0.0004
3809 Estrogen-related receptor gamma ESRRG 0.0004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0004
284 DNA-directed RNA polymerase beta chain rpoB 0.0004
5773 DNA-directed RNA polymerase beta chain rpoB 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
737 Mineralocorticoid receptor NR3C2 0.0004
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0004
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0004
1313 Lactoylglutathione lyase GLO1 0.0004
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0004
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0004
489 Monocarboxylate transporter 2 SLC16A7 0.0003
164 Histamine H4 receptor HRH4 0.0003
275 Arachidonate 5-lipoxygenase ALOX5 0.0003
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0003
952 Dipeptidyl peptidase 4 DPP4 0.0003
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0003
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
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