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DB05245 - Silver sulfadiazine


Identification
Name Silver sulfadiazine
Accession Number DB05245
Type small molecule
Description Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 357.137
Groups approved
Monoisotopic Weight 355.949714262
Pharmacology
Indication Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
Mechanism of action Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. A specific mechanism of action has not been determined, but silver sulfadiazine's effectiveness may possibly be from a synergistic interaction, or the action of each component. Silver is a biocide, which binds to a broad range of targets. Silver ions bind to nucleophilic amino acids, as well as sulfhydryl, amino, imidazole, phosphate, and carboxyl groups in proteins, causing protein denaturation and enzyme inhibition. Silver binds to surface membranes and proteins, causing proton leaks in the membrane, leading to cell death. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Absorption Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Acute oral toxicity (LD50) in rat is 10001 mg/kg.
Affected organisms
  • Yeast and other fungi
  • Various gram-negative and gram-positive eubacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions binder
References
  • McDonnell G, Russell AD: Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999 Jan;12(1):147-79. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
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