DT-Web

DB04836 - Amineptine


Identification
Name Amineptine
Accession Number DB04836
Type small molecule
Description The Food and Drug Administration suspended the marketing authorisation for Survector in 1999 and France withdrew it from the market, however several developing countries continued to produce it up until 2005.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 373.916
Groups illicit
Monoisotopic Weight 373.180856852
Pharmacology
Indication For the treatment of depression.
Mechanism of action Amineptine selectively inhibits the reuptake of dopamine and to a lesser extent norepinephrine, thus exerting a powerful and fast-acting antidepressant effect.
Absorption Not Available
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Take with food to reduce irritation.
  • Avoid St.John's Wort.
  • Avoid alcohol.

Targets


Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.442
Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.3256

Predictions


Id Partner name Gene Name Score
713 Sodium-dependent dopamine transporter SLC6A3 0.1795
4119 Cytochrome P450 2D6 CYP2D6 0.1258
4512 Cytochrome P450 3A4 CYP3A4 0.0772
556 Alpha-1A adrenergic receptor ADRA1A 0.0645
1588 Multidrug resistance protein 1 ABCB1 0.052
3941 Amine oxidase [flavin-containing] A MAOA 0.0463
502 5-hydroxytryptamine 2A receptor HTR2A 0.0446
131 Synaptic vesicular amine transporter SLC18A2 0.0438
6016 Cytochrome P450 2C19 CYP2C19 0.0433
590 5-hydroxytryptamine 2C receptor HTR2C 0.0415
4200 Cytochrome P450 1A2 CYP1A2 0.039
3939 Amine oxidase [flavin-containing] B MAOB 0.0381
318 Alpha-2A adrenergic receptor ADRA2A 0.0367
4757 Cytochrome P450 2C9 CYP2C9 0.0335
492 Histamine H1 receptor HRH1 0.0322
6030 Cytochrome P450 2B6 CYP2B6 0.0307
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0299
436 5-hydroxytryptamine 2B receptor HTR2B 0.0272
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.026
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0252
632 Alpha-1B adrenergic receptor ADRA1B 0.0235
6013 Cytochrome P450 2E1 CYP2E1 0.0191
629 Alpha-2B adrenergic receptor ADRA2B 0.0182
320 5-hydroxytryptamine 1A receptor HTR1A 0.0179
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0172
4118 Cytochrome P450 3A5 CYP3A5 0.0171
617 Muscarinic acetylcholine receptor M2 CHRM2 0.016
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0154
4924 Cytochrome P450 2C8 CYP2C8 0.0154
450 Muscarinic acetylcholine receptor M4 CHRM4 0.015
6107 Cytochrome P450 3A7 CYP3A7 0.0149
193 Beta-1 adrenergic receptor ADRB1 0.0143
766 Beta-2 adrenergic receptor ADRB2 0.014
378 Alpha-2C adrenergic receptor ADRA2C 0.0134
789 Alpha-1D adrenergic receptor ADRA1D 0.0132
831 D(2) dopamine receptor DRD2 0.0123
1636 Trace amine-associated receptor 1 TAAR1 0.0121
6144 Solute carrier family 22 member 2 SLC22A2 0.0115
1656 CYP2B protein CYP2B 0.0113
6432 Transporter snf 0.0111
467 Delta-type opioid receptor OPRD1 0.0104
696 Kappa-type opioid receptor OPRK1 0.0104
1517 Beta-3 adrenergic receptor ADRB3 0.0101
23 D(1A) dopamine receptor DRD1 0.0098
6106 Cytochrome P450 2C18 CYP2C18 0.0096
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0091
6145 Solute carrier family 22 member 1 SLC22A1 0.0088
6147 Solute carrier family 22 member 3 SLC22A3 0.0088
6182 Cytochrome P450 2J2 CYP2J2 0.0086
847 Mu-type opioid receptor OPRM1 0.0084
587 Serum albumin ALB 0.0074
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.007
474 Acetylcholinesterase ACHE 0.0069
118 Organic cation/carnitine transporter 2 SLC22A5 0.0068
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0066
6024 Cytochrome P450 1A1 CYP1A1 0.0065
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0061
5718 Cytochrome P450 2A6 CYP2A6 0.0059
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0058
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0052
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0052
341 5-hydroxytryptamine 3 receptor HTR3A 0.005
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0047
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0046
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0046
2981 Phospholipase A2, membrane associated PLA2G2A 0.0044
1757 Myeloperoxidase MPO 0.0044
828 Phenylalanine-4-hydroxylase PAH 0.0043
3109 Phenylalanine-4-hydroxylase phhA 0.0043
904 Glutathione S-transferase P GSTP1 0.0042
833 Organic cation/carnitine transporter 1 SLC22A4 0.0042
3923 Cholinesterase BCHE 0.0042
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0041
482 Glycine receptor subunit alpha-1 GLRA1 0.004
94 5-hydroxytryptamine 4 receptor HTR4 0.0037
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0036
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0036
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0036
1360 Sphingomyelin phosphodiesterase SMPD1 0.0036
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0033
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0031
319 Opioid receptor, sigma 1 OPRS1 0.0031
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0027
174 Sigma 1-type opioid receptor SIGMAR1 0.0026
1618 High affinity nerve growth factor receptor NTRK1 0.0025
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0024
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0024
124 Histamine H2 receptor HRH2 0.0022
725 5-hydroxytryptamine 1D receptor HTR1D 0.0019
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0019
885 5-hydroxytryptamine 1B receptor HTR1B 0.0019
20 Prostaglandin G/H synthase 1 PTGS1 0.0018
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0018
6151 Monocarboxylate transporter 10 SLC16A10 0.0018
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.001
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.001
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.001
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0009
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0009
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0009
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0009
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0009
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0009
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0008
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0008
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0008
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0008
6148 Multidrug resistance-associated protein 7 ABCC10 0.0007
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0007
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0007
776 Bile salt export pump ABCB11 0.0006
2164 Multidrug resistance-associated protein 4 ABCC4 0.0006
862 Multidrug resistance-associated protein 1 ABCC1 0.0006
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0006
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0006
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0005
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