DT-Web

DB03944 - 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One


Identification
Name 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One
Accession Number DB03944 (EXPT01339)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 425.501
Groups experimental
Monoisotopic Weight 425.140926929
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Troponin C, slow skeletal and cardiac muscles
Name Troponin C, slow skeletal and cardiac muscles
Gene Name TNNC1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4418

Predictions


Id Partner name Gene Name Score
465 Calmodulin CALM1 0.0896
722 Troponin I, cardiac muscle TNNI3 0.0831
4246 Voltage-dependent anion-selective channel protein 2 VDAC2 0.0564
4247 Voltage-dependent anion-selective channel protein 3 VDAC3 0.0564
4245 Voltage-dependent anion-selective channel protein 1 VDAC1 0.0563
1108 Calpastatin CAST 0.0403
1089 Cartilage oligomeric matrix protein COMP 0.0403
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0403
6048 Troponin C, skeletal muscle TNNC2 0.0396
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0376
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0351
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0262
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.025
6859 Protein S100-A4 S100A4 0.0233
2132 Protein S100-B S100B 0.0232
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0232
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0223
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0203
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.019
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0181
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.018
1588 Multidrug resistance protein 1 ABCB1 0.0174
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0152
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0142
3947 Xanthine dehydrogenase/oxidase XDH 0.012
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0118
4119 Cytochrome P450 2D6 CYP2D6 0.0101
831 D(2) dopamine receptor DRD2 0.0097
556 Alpha-1A adrenergic receptor ADRA1A 0.0094
4200 Cytochrome P450 1A2 CYP1A2 0.0075
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.007
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0069
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0069
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0068
737 Mineralocorticoid receptor NR3C2 0.0068
6107 Cytochrome P450 3A7 CYP3A7 0.0042
4118 Cytochrome P450 3A5 CYP3A5 0.004
4924 Cytochrome P450 2C8 CYP2C8 0.004
4757 Cytochrome P450 2C9 CYP2C9 0.0036
4512 Cytochrome P450 3A4 CYP3A4 0.0032
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