DT-Web

DB03882 - 5-Alpha-Androstane-3-Beta,17beta-Diol


Identification
Name 5-Alpha-Androstane-3-Beta,17beta-Diol
Accession Number DB03882 (DB01507, EXPT00530)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 292.4562
Groups experimental
Monoisotopic Weight 292.240230268
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Estrogen receptor beta
Name Estrogen receptor beta
Gene Name ESR2
Pharmacological action unknown
Actions agonist
References
  • Norata GD, Cattaneo P, Poletti A, Catapano AL: The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits tumor necrosis factor alpha and lipopolysaccharide induced inflammatory response in human endothelial cells and in mice aorta. Atherosclerosis. 2010 Sep;212(1):100-6. Epub 2010 May 19. - Pubmed
DTHybrid score 0.9133

Carriers


Predictions


Id Partner name Gene Name Score
6228 Nuclear receptor coactivator 1 NCOA1 0.2444
136 Estrogen receptor ESR1 0.1569
146 Androgen receptor AR 0.0785
3811 Cytochrome P450 19A1 CYP19A1 0.0651
6560 Nuclear receptor coactivator 5 NCOA5 0.0526
3437 Eosinophil lysophospholipase CLC 0.0424
4512 Cytochrome P450 3A4 CYP3A4 0.0396
1588 Multidrug resistance protein 1 ABCB1 0.0361
269 Adrenodoxin, mitochondrial FDX1 0.0348
381 Prolactin receptor PRLR 0.0347
587 Serum albumin ALB 0.0291
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0284
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0283
614 Progesterone receptor PGR 0.0237
232 Corticosteroid-binding globulin SERPINA6 0.0229
871 Glucocorticoid receptor NR3C1 0.0224
6107 Cytochrome P450 3A7 CYP3A7 0.0172
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0171
6145 Solute carrier family 22 member 1 SLC22A1 0.0171
1649 Small inducible cytokine A2 CCL2 0.0167
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0163
4118 Cytochrome P450 3A5 CYP3A5 0.0163
4757 Cytochrome P450 2C9 CYP2C9 0.0158
4924 Cytochrome P450 2C8 CYP2C8 0.0157
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0155
380 Cytochrome P450 17A1 CYP17A1 0.0154
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0153
4200 Cytochrome P450 1A2 CYP1A2 0.0147
6030 Cytochrome P450 2B6 CYP2B6 0.0143
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0141
226 Gonadotropin-releasing hormone receptor GNRHR 0.0136
2107 Microtubule-associated protein 1A MAP1A 0.013
6142 Solute carrier family 22 member 8 SLC22A8 0.0129
6016 Cytochrome P450 2C19 CYP2C19 0.0113
469 Annexin A1 ANXA1 0.0112
1852 Microtubule-associated protein 2 MAP2 0.0097
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0086
1898 Cytochrome P450 1B1 CYP1B1 0.0079
373 Transthyretin TTR 0.0077
6147 Solute carrier family 22 member 3 SLC22A3 0.0064
6024 Cytochrome P450 1A1 CYP1A1 0.0063
6020 Aldehyde oxidase AOX1 0.0062
992 Protein tyrosine kinase 2 beta PTK2B 0.0062
6085 Fatty acid-binding protein, intestinal FABP2 0.0057
3809 Estrogen-related receptor gamma ESRRG 0.005
6241 Nuclear receptor coactivator 2 NCOA2 0.005
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0049
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0047
6014 Cytochrome P450 2A13 CYP2A13 0.0046
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0042
6148 Multidrug resistance-associated protein 7 ABCC10 0.0041
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0039
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0038
5718 Cytochrome P450 2A6 CYP2A6 0.0038
3810 Catechol O-methyltransferase COMT 0.0037
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0036
817 DNA topoisomerase 2-alpha TOP2A 0.0036
6141 Sodium/bile acid cotransporter SLC10A1 0.0035
1024 Solute carrier family 22 member 11 SLC22A11 0.0035
6031 Cytochrome P450 3A43 CYP3A43 0.0035
6013 Cytochrome P450 2E1 CYP2E1 0.0034
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0033
6144 Solute carrier family 22 member 2 SLC22A2 0.0032
862 Multidrug resistance-associated protein 1 ABCC1 0.0032
833 Organic cation/carnitine transporter 1 SLC22A4 0.0028
3941 Amine oxidase [flavin-containing] A MAOA 0.0027
1192 Sulfotransferase 1A1 SULT1A1 0.0027
6143 Solute carrier family 22 member 7 SLC22A7 0.0026
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0023
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.002
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0019
4604 Liver carboxylesterase 1 CES1 0.0018
776 Bile salt export pump ABCB11 0.0015
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0013
4119 Cytochrome P450 2D6 CYP2D6 0.001
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