DT-Web

DB03878 - N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide


Identification
Name N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
Accession Number DB03878 (EXPT02657)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 382.4179
Groups experimental
Monoisotopic Weight 382.154209228
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Tyrosine-protein kinase transforming protein Abl
Name Tyrosine-protein kinase transforming protein Abl
Gene Name ABL
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1015
Proto-oncogene tyrosine-protein kinase ABL1
Name Proto-oncogene tyrosine-protein kinase ABL1
Gene Name ABL1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9642

Predictions


Id Partner name Gene Name Score
504 Mast/stem cell growth factor receptor KIT 0.0307
6824 Tyrosine-protein kinase Lyn LYN 0.0243
5449 Hypothetical gliding protein mglB 0.0196
4705 Manganese catalase Not Available 0.0196
5443 UPF0189 protein ymdB ymdB 0.0196
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0196
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0196
5439 33 kDa chaperonin hslO 0.0196
332 Beta-lactamase blaZ 0.0196
2478 Beta-lactamase ampC 0.0196
2613 Beta-lactamase ampC 0.0196
2635 Beta-lactamase ampC 0.0196
2700 Beta-lactamase penP 0.0196
5445 Beta-lactamase blaB 0.0196
6019 Beta-lactamase SHV-7 0.0196
6701 Beta-lactamase cphA 0.0196
5448 Ribonuclease Z rnz 0.0196
5440 UPF0067 protein yebR yebR 0.0196
2720 Copper-containing nitrite reductase nirK 0.0196
5454 Internalin-A inlA 0.0196
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0196
1588 Multidrug resistance protein 1 ABCB1 0.0193
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.019
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0184
2714 Chorismate mutase aroH 0.0171
4611 Chorismate mutase aroG 0.0171
4498 Ornithine cyclodeaminase PP3533 0.0171
4771 Dissimilatory copper-containing nitrite reductase nir 0.0171
3356 Diaminopimelate decarboxylase lysA 0.0171
5450 Prolyl endopeptidase Pep pep 0.0171
3274 Hydroxylamine reductase hcp 0.0171
4804 Hydroxylamine reductase hcp 0.0171
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0169
2599 Tyrosine-protein kinase HCK HCK 0.016
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0158
3399 Limonene-1,2-epoxide hydrolase limA 0.0158
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0158
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0158
4512 Cytochrome P450 3A4 CYP3A4 0.0157
228 Beta platelet-derived growth factor receptor PDGFRB 0.0151
5180 L(+)-mandelate dehydrogenase mdlB 0.0149
3500 Putative family 31 glucosidase yicI yicI 0.0149
1615 Chymase CMA1 0.0142
4608 Putative cytochrome P450 SCO1207 0.0142
4963 Putative cytochrome P450 SCO2884 0.0142
6254 Putative cytochrome P450 SCO6998 0.0142
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0137
597 Dihydropteridine reductase QDPR 0.0137
3480 Mannan endo-1,4-beta-mannosidase manA 0.0137
577 Argininosuccinate lyase ASL 0.0136
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0136
365 Dihydrofolate reductase DHFR 0.0133
2381 Dihydrofolate reductase DFR1 0.0133
2833 Dihydrofolate reductase Not Available 0.0133
2931 Dihydrofolate reductase folA 0.0133
3544 Dihydrofolate reductase folA 0.0133
3682 Dihydrofolate reductase folA 0.0133
6642 Dihydrofolate reductase folA 0.0133
6756 Dihydrofolate reductase dfrA 0.0133
936 Ephrin type-A receptor 2 EPHA2 0.0133
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0128
5787 Angiopoietin-1 receptor TEK 0.0127
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0115
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0113
823 Fibroblast growth factor receptor 2 FGFR2 0.0112
484 Tyrosine-protein kinase ABL2 ABL2 0.0112
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0108
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0105
1618 High affinity nerve growth factor receptor NTRK1 0.0101
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0098
4924 Cytochrome P450 2C8 CYP2C8 0.0091
407 Vascular endothelial growth factor receptor 2 KDR 0.0091
904 Glutathione S-transferase P GSTP1 0.0089
4119 Cytochrome P450 2D6 CYP2D6 0.0083
2216 Fibroblast growth factor receptor 4 FGFR4 0.0082
4757 Cytochrome P450 2C9 CYP2C9 0.0081
2240 Cell division protein kinase 2 CDK2 0.0079
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0079
474 Acetylcholinesterase ACHE 0.0077
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0076
5798 Mitogen-activated protein kinase 11 MAPK11 0.0076
1063 Signal transducer and activator of transcription 5B STAT5B 0.0076
3856 Fibroblast growth factor receptor 3 FGFR3 0.0075
6030 Cytochrome P450 2B6 CYP2B6 0.0075
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0072
4118 Cytochrome P450 3A5 CYP3A5 0.0071
3923 Cholinesterase BCHE 0.0062
1864 RET proto-oncogene RET 0.006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.006
165 FL cytokine receptor FLT3 0.0059
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0056
776 Bile salt export pump ABCB11 0.0052
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0051
26 Vascular endothelial growth factor receptor 3 FLT4 0.005
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.005
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0049
32 Vascular endothelial growth factor receptor 1 FLT1 0.0049
4200 Cytochrome P450 1A2 CYP1A2 0.0045
340 Apoptotic protease-activating factor 1 APAF1 0.0043
292 Activin receptor type-1 ACVR1 0.0041
849 Activated CDC42 kinase 1 TNK2 0.0041
394 Calcineurin subunit B isoform 1 PPP3R1 0.0041
6753 Apolipoprotein M APOM 0.0041
6742 Recoverin RCVRN 0.0041
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0041
6747 Chalcone/stilbene synthase family protein MT1417 0.0041
6743 Non-fluorescent flavoprotein luxF 0.0041
2528 Fatty acid metabolism regulator protein fadR 0.0041
6740 Fatty acid metabolism regulator protein fadR 0.0041
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0041
6751 Gag polyprotein gag 0.0041
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0041
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0041
6749 Polyprotein Not Available 0.0041
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0039
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0039
395 ALK tyrosine kinase receptor Not Available 0.0039
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0039
733 Activin receptor type 1B ACVR1B 0.0039
825 Arsenical pump-driving ATPase ASNA1 0.0039
3435 Arsenical pump-driving ATPase arsA 0.0039
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0039
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0039
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0039
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0039
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0039
154 AFG3-like protein 2 AFG3L2 0.0039
6016 Cytochrome P450 2C19 CYP2C19 0.0038
1898 Cytochrome P450 1B1 CYP1B1 0.0037
5961 Insulin INS 0.0036
6755 Poliovirus receptor PVR 0.0036
6527 Lymphocyte antigen 96 LY96 0.0036
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0035
661 ADP/ATP translocase 1 SLC25A4 0.0035
587 Serum albumin ALB 0.0034
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0034
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0034
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0034
297 Adenylate cyclase type 1 ADCY1 0.0034
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0034
6750 ADP-ribosylation factor 6 ARF6 0.0033
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0033
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0033
6524 Protein tonB tonB 0.0033
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0033
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0031
2616 Ganglioside GM2 activator GM2A 0.0031
6021 Adenosine kinase ADK 0.0031
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0031
6024 Cytochrome P450 1A1 CYP1A1 0.003
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.003
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.003
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.003
4210 Toll-like receptor 4 TLR4 0.0029
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0029
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
6316 ADP-ribosylation factor 1 ARF1 0.0028
2297 Genome polyprotein Not Available 0.0028
2322 Genome polyprotein Not Available 0.0028
2694 Genome polyprotein Not Available 0.0028
2719 Genome polyprotein Not Available 0.0028
2860 Genome polyprotein Not Available 0.0028
2928 Genome polyprotein Not Available 0.0028
3160 Genome polyprotein Not Available 0.0028
3260 Genome polyprotein Not Available 0.0028
4783 Genome polyprotein Not Available 0.0028
5726 Genome polyprotein Not Available 0.0028
5779 Genome polyprotein Not Available 0.0028
5867 Genome polyprotein Not Available 0.0028
6253 Genome polyprotein Not Available 0.0028
6301 Genome polyprotein Not Available 0.0028
6380 Genome polyprotein Not Available 0.0028
6381 Genome polyprotein Not Available 0.0028
6437 Genome polyprotein Not Available 0.0028
6520 Genome polyprotein Not Available 0.0028
6521 Genome polyprotein Not Available 0.0028
6652 Genome polyprotein Not Available 0.0028
6734 Genome polyprotein Not Available 0.0028
6735 Genome polyprotein Not Available 0.0028
6736 Genome polyprotein Not Available 0.0028
6737 Genome polyprotein Not Available 0.0028
6738 Genome polyprotein Not Available 0.0028
6739 Genome polyprotein Not Available 0.0028
6744 Genome polyprotein Not Available 0.0028
6748 Genome polyprotein Not Available 0.0028
6894 Genome polyprotein Not Available 0.0028
6898 Genome polyprotein Not Available 0.0028
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0027
864 Gag-Pol polyprotein gag-pol 0.0026
2237 Gag-Pol polyprotein gag-pol 0.0026
2326 Gag-Pol polyprotein gag-pol 0.0026
2451 Gag-Pol polyprotein gag-pol 0.0026
2901 Gag-Pol polyprotein gag-pol 0.0026
3165 Gag-Pol polyprotein gag-pol 0.0026
3722 Gag-Pol polyprotein gag-pol 0.0026
6306 Gag-Pol polyprotein gag-pol 0.0026
6624 Gag-Pol polyprotein gag-pol 0.0026
6144 Solute carrier family 22 member 2 SLC22A2 0.0025
6145 Solute carrier family 22 member 1 SLC22A1 0.0024
6085 Fatty acid-binding protein, intestinal FABP2 0.0024
20 Prostaglandin G/H synthase 1 PTGS1 0.0024
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0023
2427 Ferrichrome-iron receptor fhuA 0.0023
768 FK506-binding protein 1A FKBP1A 0.0022
6228 Nuclear receptor coactivator 1 NCOA1 0.0022
6107 Cytochrome P450 3A7 CYP3A7 0.0021
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0021
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0019
465 Calmodulin CALM1 0.0018
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0017
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