DT-Web

DB03608 - Diminazene


Identification
Name Diminazene
Accession Number DB03608 (EXPT00754)
Type small molecule
Description An effective trypanocidal agent.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 281.3158
Groups experimental
Monoisotopic Weight 281.138893515
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Peroxiredoxin-5, mitochondrial
Name Peroxiredoxin-5, mitochondrial
Gene Name PRDX5
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6226
HTH-type transcriptional regulator qacR
Name HTH-type transcriptional regulator qacR
Gene Name qacR
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.2728
Trypsin-1
Name Trypsin-1
Gene Name PRSS1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.8697
Amiloride-sensitive amine oxidase [copper-containing]
Name Amiloride-sensitive amine oxidase [copper-containing]
Gene Name ABP1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5143

Predictions


Id Partner name Gene Name Score
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.5143
2331 HTH-type transcriptional regulator qacR qacR 0.2728
54 Prothrombin F2 0.1871
6828 TetR family transcriptional repressor LfrR lfrR 0.1829
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.1204
1074 Urokinase-type plasminogen activator PLAU 0.093
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0656
587 Serum albumin ALB 0.0615
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0567
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0524
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0524
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0523
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0523
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0515
3014 Ribonuclease UK114 HRSP12 0.034
3617 Non-heme chloroperoxidase cpo 0.034
5426 Non-heme chloroperoxidase cpo 0.034
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0339
5428 Replication protein repA 0.0339
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0339
3018 HTH-type transcriptional regulator malT malT 0.0339
3115 Ras-related protein Rab-9 RAB9A 0.0297
2958 Probable tautomerase ydcE pptA 0.0296
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0295
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0295
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0295
2573 Cocaine esterase cocE 0.0295
7263 Cocaine esterase Not Available 0.0295
833 Organic cation/carnitine transporter 1 SLC22A4 0.0276
2693 Heat-labile enterotoxin B chain eltB 0.0234
6144 Solute carrier family 22 member 2 SLC22A2 0.0232
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.023
6145 Solute carrier family 22 member 1 SLC22A1 0.0226
6645 D-amino-acid oxidase DAO 0.0224
3851 Serine protease hepsin HPN 0.0215
6011 Chymotrypsinogen B CTRB1 0.018
2324 Botulinum neurotoxin type B botB 0.017
2686 Tryptase beta-2 TPSB2 0.0162
738 Monocarboxylate transporter 1 SLC16A1 0.0155
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0148
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0148
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0148
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0139
2255 Copper amine oxidase tynA 0.0129
2914 Triosephosphate isomerase, glycosomal Not Available 0.0123
6142 Solute carrier family 22 member 8 SLC22A8 0.0111
1812 Kallikrein-1 KLK1 0.0107
2517 Subtilisin BPN' apr 0.0103
3382 Glycolipid transfer protein GLTP 0.0099
6882 Iodotyrosine dehalogenase 1 IYD 0.0071
6881 Nickel-binding periplasmic protein nikA 0.0071
6880 Alpha-amylase G-6 BH0413 0.0071
234 Plasminogen PLG 0.0062
474 Acetylcholinesterase ACHE 0.0056
2889 Kallikrein-6 KLK6 0.0047
2947 Trypsin sprT 0.0047
3011 Suppressor of tumorigenicity protein 14 ST14 0.0041
4814 Copper transport protein ATOX1 ATOX1 0.0041
3211 3,2-trans-enoyl-CoA isomerase, mitochondrial DCI 0.0041
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0036
2886 Trypsin-3 PRSS3 0.0034
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0033
2236 Casein kinase II subunit alpha CSNK2A1 0.0025
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