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DB03450 - Cephalothin Group


Identification
Name Cephalothin Group
Accession Number DB03450 (EXPT00891)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 398.454
Groups experimental
Monoisotopic Weight 398.060627698
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Gentamicin Increased risk of nephrotoxicity
Netilmicin Increased risk of nephrotoxicity
Probenecid Probenecid may increase the serum level of cephalothin.
Tobramycin Increased risk of nephrotoxicity
Food Interactions Not Available

Targets


Beta-lactamase Toho-1
Name Beta-lactamase Toho-1
Gene Name bla
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.3085
D-alanyl-D-alanine carboxypeptidase
Name D-alanyl-D-alanine carboxypeptidase
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.71

Predictions


Id Partner name Gene Name Score
5756 D-alanyl-D-alanine carboxypeptidase dac 1.71
645 Penicillin-binding protein 1A mrcA 0.1301
5805 Penicillin-binding protein 1A ponA 0.1301
6185 Penicillin-binding protein 1A mrcA 0.1301
6799 Penicillin-binding protein 1A pbpA 0.1301
332 Beta-lactamase blaZ 0.1194
2478 Beta-lactamase ampC 0.1194
2613 Beta-lactamase ampC 0.1194
2635 Beta-lactamase ampC 0.1194
2700 Beta-lactamase penP 0.1194
5445 Beta-lactamase blaB 0.1194
6019 Beta-lactamase SHV-7 0.1194
6701 Beta-lactamase cphA 0.1194
2457 Bacillolysin nprS 0.0438
543 Penicillin-binding protein 1B mrcB 0.0295
6186 Penicillin-binding protein 1B ponB 0.0295
6822 Penicillin-binding protein 1b pbp1b 0.0295
6844 Penicillin-binding protein 1b pbp1b 0.0295
159 Penicillin-binding protein 2B penA 0.0282
6121 Penicillin-binding protein 2B penA 0.0282
6151 Monocarboxylate transporter 10 SLC16A10 0.0267
633 Penicillin-binding proteins 1A/1B pbpA 0.0058
1024 Solute carrier family 22 member 11 SLC22A11 0.0051
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.005
6143 Solute carrier family 22 member 7 SLC22A7 0.0049
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0048
118 Organic cation/carnitine transporter 2 SLC22A5 0.0048
6142 Solute carrier family 22 member 8 SLC22A8 0.0045
587 Serum albumin ALB 0.0042
1729 Solute carrier family 22 member 6 SLC22A6 0.0041
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