Identification
Name Cardiolipin
Accession Number DB03429 (EXPT00874)
Type small molecule
Description Cardiolipin (bisphosphatidyl glycerol) is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid. It is typically present in metabolically active cells of the heart and skeletal muscle, in the membranes of their mitochondria, mostly in the inner membrane, and consists roughly 20% of its lipids. It has also been observed in certain bacterial membranes. It serves as an insulator and stabilizes the activity of protein complexes important to the electron transport chain. It also "glues" them together. Cardiolipin is a "double" phospholipid because it has four fatty acid tails, instead of the usual two. [Wikipedia]
Structure
Categories (*)
Molecular Weight 1466.0585
Groups experimental
Monoisotopic Weight 1465.097426654
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available
ADP/ATP translocase 1
Name ADP/ATP translocase 1
Gene Name SLC25A4
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0483
Id Partner name Gene Name Score
1900 Bactericidal permeability-increasing protein BPI 0.1771
782 ADP/ATP translocase 2 SLC25A5 0.081
688 ADP/ATP translocase 3 SLC25A6 0.0808
290 Prostaglandin G/H synthase 2 PTGS2 0.0286
340 Apoptotic protease-activating factor 1 APAF1 0.0087
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0081
825 Arsenical pump-driving ATPase ASNA1 0.0081
3435 Arsenical pump-driving ATPase arsA 0.0081
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0081
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0081
154 AFG3-like protein 2 AFG3L2 0.0081
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0081
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0081
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0081
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0081
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0081
733 Activin receptor type 1B ACVR1B 0.0081
395 ALK tyrosine kinase receptor Not Available 0.0081
292 Activin receptor type-1 ACVR1 0.008
849 Activated CDC42 kinase 1 TNK2 0.008
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.007
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.007
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.007
297 Adenylate cyclase type 1 ADCY1 0.007
484 Tyrosine-protein kinase ABL2 ABL2 0.0069
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0068
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0067
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0066
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0062
6021 Adenosine kinase ADK 0.0061
132 ATP-binding cassette sub-family A member 1 ABCA1 0.006
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0058
740 Argininosuccinate synthase ASS1 0.0056
865 Argininosuccinate synthase ASS1 0.0056
2680 Argininosuccinate synthase argG 0.0056
3194 Argininosuccinate synthase argG 0.0056
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0054
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0044
776 Bile salt export pump ABCB11 0.0038
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0032
1588 Multidrug resistance protein 1 ABCB1 0.0025