DT-Web

DB03205 - Pyrroloquinoline Quinone


Identification
Name Pyrroloquinoline Quinone
Accession Number DB03205 (EXPT02652)
Type small molecule
Description A pyrrolo-quinoline having two adjacent keto-groups at the 4 and 5 positions and three acidic carboxyl groups. It is a coenzyme of some DEHYDROGENASES. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 329.1981
Groups experimental
Monoisotopic Weight 329.004590146
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Quinohaemoprotein ethanol dehydrogenase type-1
Name Quinohaemoprotein ethanol dehydrogenase type-1
Gene Name qheDH
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.6445
Quinoprotein glucose dehydrogenase-B
Name Quinoprotein glucose dehydrogenase-B
Gene Name gdhB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.602
Quinohemoprotein alcohol dehydrogenase ADH IIB
Name Quinohemoprotein alcohol dehydrogenase ADH IIB
Gene Name qbdA
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.0234
Pyrroloquinoline-quinone synthase
Name Pyrroloquinoline-quinone synthase
Gene Name pqqC
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.19
Quinoprotein ethanol dehydrogenase
Name Quinoprotein ethanol dehydrogenase
Gene Name exaA
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.1902

Predictions


Id Partner name Gene Name Score
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.2253
4948 Cytochrome c-553 Not Available 0.0287
4923 Cytochrome c3 DvMF_2499 0.0287
4945 Cytochrome c3 Not Available 0.0287
4949 Cytochrome c3 DVU_3171 0.0287
4968 Cytochrome c3 cytc3 0.0287
4997 Cytochrome c3 SO_2727 0.0287
5219 Cytochrome c3 cyd 0.0287
4902 Nine-heme cytochrome c Ddes_2038 0.0287
3189 High-molecular-weight cytochrome c hmcA 0.0286
4386 Hemoglobin-like protein HbN glbN 0.0264
3221 Cytochrome c4 cc4 0.025
3152 Cytochrome c'' cycA 0.0244
5221 Cytochrome c3, 13 kDa Not Available 0.0244
5220 Split-Soret cytochrome c Ddes_2150 0.0244
3700 Cytochrome c-552 precursor nrfA 0.0244
1507 Cytochrome c CYCS 0.0213
3127 Nitrite reductase nirS 0.0212
3284 Nitrite reductase nirS 0.0212
3689 Endoglucanase A celA 0.0086
5411 Slt-IIvB stxB2e 0.0085
5563 Galectin-2 LGALS2 0.0085
3009 Beta-glucanase Not Available 0.0085
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0085
5046 Ecotin eco 0.0085
3793 Aspartate ammonia-lyase aspA 0.0085
5554 D-galactose-binding periplasmic protein mglB 0.0085
3741 D-galactose-binding periplasmic protein precursor mglB 0.0085
5568 Endoglucanase C307 celC307 0.0085
1875 Pulmonary surfactant-associated protein D SFTPD 0.0085
4668 Laminarinase TM_0024 0.0085
5562 Hexokinase Not Available 0.0085
5569 Endo-1,4-beta glucanase EngF engF 0.0085
5553 Endoglucanase E1 Acel_0614 0.0085
5570 Endoglucanase E-4 celD 0.0085
5559 Neopullulanase nplT 0.0085
4670 Cellulase B celB 0.0085
4667 BH0236 protein BH0236 0.0085
4943 Cytochrome c6 petJ 0.0085
3744 Endoglucanase SS precursor celS 0.0085
4975 Cytochrome c-556 RPA3973 0.0085
4994 Hemoglobin-like protein HbO glbO 0.0085
4671 Endoglucanase C cenC 0.0085
4934 Cytochrome c-551 nirM 0.0085
5218 Cytochrome c-551 nirM 0.0085
4905 Cytochrome c2 Not Available 0.0085
4939 Cytochrome c2 cycA 0.0085
4964 Cytochrome c2 cycA 0.0085
4979 Cytochrome c2 cycA 0.0085
6673 Cytochrome c2 cycA 0.0085
4936 Cytochrome c2 iso-2 Not Available 0.0085
4916 Cyanoglobin glbN 0.0085
4915 Cytochrome c-550 psbV 0.0085
4959 Cytochrome c-550 psbV 0.0085
5216 Cytochrome c-550 psbV 0.0085
4925 Cytochrome c-type protein SHP shp 0.0085
4942 Diheme cytochrome c napB napB 0.0085
4984 Neuroglobin NGB 0.0085
3116 Bacterioferritin bfr 0.0085
4906 Bacterioferritin bfr 0.0085
4965 Bacterioferritin bfr 0.0085
4954 Soluble cytochrome b558 Not Available 0.0085
4961 Hemophore HasA hasA 0.0085
4910 Cytoglobin CYGB 0.0085
4907 Cytochrome c-L moxG 0.0085
6865 Cytochrome c-L moxG 0.0085
4981 Iron-starvation protein PigA pigA 0.0085
4971 Nonaheme cytochrome c hmcA 0.0085
4909 CooA protein cooA 0.0085
5000 HemO hemO 0.0085
4998 Hemoglobin-like protein yjbI yjbI 0.0085
4935 Cytochrome c-554 cycA1 0.0085
644 Heme oxygenase 2 HMOX2 0.0085
4982 Heme oxygenase 2 pbsA2 0.0085
4947 Bacterial hemoglobin vhb 0.0085
4960 Putative cytochrome P450-family protein SCO7417 0.0085
4937 Cytochrome oxidase subunit II rcoxA 0.0085
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0085
4989 Cytochrome c551 peroxidase ccp 0.0085
5222 Cytochrome c551 peroxidase ccpA 0.0085
4976 Apocytochrome f petA 0.0085
6407 Apocytochrome f petA 0.0085
4999 Cytochrome P450 165B3 CYP165B3 0.0085
4972 P450cin cinA 0.0085
4764 Cytochrome P450 165C4 CYP165C4 0.0085
4931 Cytochrome P450 167A1 CYP167A1 0.0085
4922 Cytochrome c, putative SO_4144 0.0085
4952 Catalase/peroxidase katA 0.0085
4993 Hydroxylamine oxidoreductase hao1 0.0085
4903 Methyl-accepting chemotaxis protein Tar4 0.0085
4904 Cytochrome c family protein GSU1996 0.0085
3093 Catalase HPII katE 0.0085
4926 Heme-based aerotactic transducer hemAT hemAT 0.0085
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0085
4757 Cytochrome P450 2C9 CYP2C9 0.0076
1503 Galectin-7 LGALS7 0.0074
1184 Interferon beta IFNB1 0.0074
4509 Acetoin(diacetyl) reductase budC 0.0074
5498 Maltoporin lamB 0.0074
5561 Maltoporin lamB 0.0074
4622 Amylase Not Available 0.0074
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0074
5416 Coat protein VP1 Not Available 0.0074
5247 Endo-1,4-beta-xylanase Not Available 0.0074
5248 Endo-1,4-beta-xylanase xlnA 0.0074
5250 Endo-1,4-beta-xylanase xyl 0.0074
4669 Endo-1,4-beta-xylanase A xynA 0.0074
4715 Endo-1,4-beta-xylanase A xlnA 0.0074
5560 Endo-1,4-beta-xylanase A xynA 0.0074
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0074
2119 Cytochrome b5 CYB5A 0.0074
5176 YtnJ moxC 0.0074
2705 Dimethyl sulfoxide reductase dmsA 0.0074
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0074
3375 Acidic cytochrome c3 Not Available 0.0074
4385 Cytochrome c' Not Available 0.0074
4967 Cytochrome c' cycA 0.0074
5038 Cytochrome c' Not Available 0.0074
5223 Cytochrome c' cycP 0.0074
4990 PpcA ppcA 0.0074
4813 Heme oxygenase hmuO 0.0074
5769 Heme oxygenase Not Available 0.0074
4037 Hypothetical protein GPX1 0.0074
4297 Hypothetical protein SP_1951 0.0074
4521 Hypothetical protein BC_2969 0.0074
4540 Hypothetical protein TM_1070 0.0074
4555 Hypothetical protein MT1739 0.0074
4569 Hypothetical protein mshD 0.0074
4578 Hypothetical protein PA3270 0.0074
4747 Hypothetical protein PA3967 0.0074
5177 Hypothetical protein TM_0096 0.0074
5194 Hypothetical protein PA1204 0.0074
5240 Hypothetical protein Rv2991 0.0074
5370 Hypothetical protein TM_1158 0.0074
5710 Hypothetical protein Tb927.5.1360 0.0074
4289 Cytochrome P450 TT_P0059 0.0074
6262 Cytochrome P450 staP 0.0074
4992 Cytochrome c peroxidase Not Available 0.0074
3570 Cytochrome P450 152A1 cypC 0.0074
4988 Sulfite oxidase, mitochondrial SUOX 0.0074
2915 Sensor protein fixL fixL 0.0074
4944 Sensor protein fixL fixL 0.0074
4920 Peroxidase/catalase katG 0.0074
4819 Hydrolase Not Available 0.0068
5249 Hydrolase Not Available 0.0068
5436 Hydrolase Not Available 0.0068
3547 Enterotoxin type B entB 0.0068
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0068
3747 Cellulase B precursor celB 0.0068
4811 Amylosucrase ams 0.0068
2531 Alpha-amylase amyE 0.0068
2948 Alpha-amylase amy 0.0068
3169 Alpha-amylase Not Available 0.0068
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0068
2606 Neopullulanase 2 tvaII 0.0068
2541 Neopullulanase 1 tvaI 0.0068
2324 Botulinum neurotoxin type B botB 0.0068
3091 Maltodextrin phosphorylase malP 0.0068
3670 Soluble cytochrome b562 precursor cybC 0.0068
3102 Flavohemoprotein hmp 0.0068
4969 Flavohemoprotein hmp 0.0068
3291 Cytochrome c-552 cycA 0.0068
4927 Cytochrome c-552 nrfA 0.0068
4938 Cytochrome c-552 cycA 0.0068
4953 Cytochrome c-552 nrfA 0.0068
5217 Cytochrome c-552 cycM 0.0068
2617 Nitric oxide synthase oxygenase nos 0.0068
2701 Nitric oxide synthase oxygenase nos 0.0068
3411 Cytochrome P450 121 cyp121 0.0068
2230 Catalase CAT 0.0067
3249 Catalase katA 0.0067
3625 Catalase katA 0.0067
4539 Catalase katA 0.0067
4941 Catalase katB 0.0067
3225 Shiga toxin B-chain stxB 0.0065
4666 Fucose-binding lectin PA-IIL lecB 0.0065
4830 Aldose 1-epimerase galM 0.0065
2372 Bifunctional tail protein 9 0.0065
2826 Glucose--fructose oxidoreductase gfo 0.0065
3365 Beta-amylase spoII 0.0065
1881 Hexokinase-1 HK1 0.0065
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0064
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0062
2508 Cyclomaltodextrin glucanotransferase cgt 0.0062
2523 Cyclomaltodextrin glucanotransferase cgt 0.0062
3207 Cyclomaltodextrin glucanotransferase amyA 0.0062
1675 Glucokinase GCK 0.0062
4662 Glucokinase glk 0.0062
3030 Salivary alpha-amylase AMY1A 0.0062
6614 Lactase-like protein LCTL 0.0062
4608 Putative cytochrome P450 SCO1207 0.0062
4963 Putative cytochrome P450 SCO2884 0.0062
6254 Putative cytochrome P450 SCO6998 0.0062
605 Fumarate reductase flavoprotein subunit frdA 0.0061
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0061
3673 Fumarate reductase flavoprotein subunit fccA 0.0061
4912 Fumarate reductase flavoprotein subunit ifcA 0.0061
6549 Fumarate reductase flavoprotein subunit frdA 0.0061
2972 6-deoxyerythronolide B hydroxylase eryF 0.0061
518 Peroxidase/catalase T katG 0.006
3668 Maltose-binding periplasmic protein precursor malE 0.006
2802 Endoglucanase G celCCG 0.006
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.006
2570 Tetanus toxin tetX 0.0059
4692 A/G-specific adenine glycosylase mutY 0.0059
4272 POSSIBLE CELLULASE CELA1 celA1 0.0058
260 Cytochrome P450 51 ERG11 0.0058
761 Cytochrome P450 51 ERG11 0.0058
3163 Cytochrome P450 51 cyp51 0.0058
2440 Endoglucanase F celCCF 0.0055
2430 Chondroitinase B cslB 0.0055
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0054
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0054
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0054
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0054
693 Hemoglobin subunit beta HBB 0.0054
6268 Hydroxyacid oxidase 1 HAO1 0.0054
20 Prostaglandin G/H synthase 1 PTGS1 0.0053
358 Cystathionine beta-synthase CBS 0.0052
810 Heme oxygenase 1 HMOX1 0.0052
3391 Heme oxygenase 1 pbsA1 0.0052
2245 Xylose isomerase xylA 0.0051
2253 Xylose isomerase xylA 0.0051
2260 Xylose isomerase xylA 0.0051
2431 Xylose isomerase xylA 0.0051
2252 Endoglucanase 5A cel5A 0.0051
2723 Cholera enterotoxin subunit B ctxB 0.005
10 Glycogen phosphorylase, liver form PYGL 0.0048
2427 Ferrichrome-iron receptor fhuA 0.0048
2298 Cytochrome P450-cam camC 0.0047
4513 Pancreatic alpha-amylase AMY2A 0.0047
76 Nitric-oxide synthase, brain NOS1 0.0044
275 Arachidonate 5-lipoxygenase ALOX5 0.0042
7 Nitric oxide synthase, inducible NOS2 0.004
291 Nitric-oxide synthase, endothelial NOS3 0.0039
1152 Glycogen phosphorylase, muscle form PYGM 0.0039
6106 Cytochrome P450 2C18 CYP2C18 0.0036
290 Prostaglandin G/H synthase 2 PTGS2 0.0031
587 Serum albumin ALB 0.0027
6030 Cytochrome P450 2B6 CYP2B6 0.0027
4924 Cytochrome P450 2C8 CYP2C8 0.0025
4512 Cytochrome P450 3A4 CYP3A4 0.002
↑