DT-Web

DB03127 - Benzamidine


Identification
Name Benzamidine
Accession Number DB03127 (EXPT00669)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 121.1598
Groups experimental
Monoisotopic Weight 121.076573298
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Kallikrein-6
Name Kallikrein-6
Gene Name KLK6
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8059
Trypsin-2
Name Trypsin-2
Gene Name PRSS2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Trypsin-3
Name Trypsin-3
Gene Name PRSS3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 2.2645
Copper transport protein ATOX1
Name Copper transport protein ATOX1
Gene Name ATOX1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7557
3,2-trans-enoyl-CoA isomerase, mitochondrial
Name 3,2-trans-enoyl-CoA isomerase, mitochondrial
Gene Name DCI
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1884
Trypsin
Name Trypsin
Gene Name sprT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8058
Suppressor of tumorigenicity protein 14
Name Suppressor of tumorigenicity protein 14
Gene Name ST14
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7979
Urokinase-type plasminogen activator
Name Urokinase-type plasminogen activator
Gene Name PLAU
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 2.0005
Trypsin-1
Name Trypsin-1
Gene Name PRSS1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 2.0871
Casein kinase II subunit alpha
Name Casein kinase II subunit alpha
Gene Name CSNK2A1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 2.0363

Predictions


Id Partner name Gene Name Score
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.3927
54 Prothrombin F2 0.1752
3834 Nidogen-1 NID1 0.1081
3833 Plasma serine protease inhibitor SERPINA5 0.0942
1349 Plasminogen activator inhibitor 2 SERPINB2 0.0941
791 Urokinase plasminogen activator surface receptor PLAUR 0.0784
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0773
234 Plasminogen PLG 0.0715
267 Plasminogen activator inhibitor 1 SERPINE1 0.0713
1792 Tissue-type plasminogen activator PLAT 0.0684
4748 Levansucrase sacB 0.0653
4818 Beta-lactamase CTX-M-27 blaCTX-M-27 0.0653
4816 Orange carotenoid-binding protein Not Available 0.0653
4810 Beta-glucosidase bgl3 0.0653
4817 Sucrose porin scrY 0.0653
2780 Septum formation protein Maf maf 0.0569
4813 Heme oxygenase hmuO 0.0569
5769 Heme oxygenase Not Available 0.0569
4812 Extended-spectrum beta-lactamase CTX-M-14 blaCTX-M-14 0.0569
4811 Amylosucrase ams 0.0525
3367 GDP-mannose 6-dehydrogenase algD 0.0524
2617 Nitric oxide synthase oxygenase nos 0.0495
2701 Nitric oxide synthase oxygenase nos 0.0495
4629 Beta-lactamase CTX-M-9a blaCTX-M-9a 0.0412
3822 Actin, alpha skeletal muscle ACTA1 0.0402
3851 Serine protease hepsin HPN 0.0389
4531 Putative ketoacyl reductase actIII 0.0358
332 Beta-lactamase blaZ 0.0309
2478 Beta-lactamase ampC 0.0309
2613 Beta-lactamase ampC 0.0309
2635 Beta-lactamase ampC 0.0309
2700 Beta-lactamase penP 0.0309
5445 Beta-lactamase blaB 0.0309
6019 Beta-lactamase SHV-7 0.0309
6701 Beta-lactamase cphA 0.0309
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0282
6011 Chymotrypsinogen B CTRB1 0.018
2324 Botulinum neurotoxin type B botB 0.017
2686 Tryptase beta-2 TPSB2 0.0162
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0148
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0148
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0148
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0136
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0136
2255 Copper amine oxidase tynA 0.0129
2914 Triosephosphate isomerase, glycosomal Not Available 0.0123
1812 Kallikrein-1 KLK1 0.0107
2517 Subtilisin BPN' apr 0.0103
3382 Glycolipid transfer protein GLTP 0.0099
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.008
2331 HTH-type transcriptional regulator qacR qacR 0.0076
6461 HTH-type transcriptional regulator qacR qacR 0.0076
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0074
6882 Iodotyrosine dehalogenase 1 IYD 0.0071
6881 Nickel-binding periplasmic protein nikA 0.0071
6880 Alpha-amylase G-6 BH0413 0.0071
373 Transthyretin TTR 0.0065
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0065
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0062
6024 Cytochrome P450 1A1 CYP1A1 0.0059
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0056
474 Acetylcholinesterase ACHE 0.0056
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.005
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.005
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.005
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.005
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0049
1898 Cytochrome P450 1B1 CYP1B1 0.0049
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0049
997 Protein kinase C beta type PRKCB 0.0047
2408 Tyrosine-protein kinase SYK SYK 0.0047
290 Prostaglandin G/H synthase 2 PTGS2 0.0046
20 Prostaglandin G/H synthase 1 PTGS1 0.0043
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0042
6131 Carbonic anhydrase 14 CA14 0.0041
1970 Protein kinase C alpha type PRKCA 0.0041
6122 Carbonic anhydrase 3 CA3 0.0041
634 Squalene monooxygenase SQLE 0.0037
7196 Squalene monooxygenase ERG1 0.0037
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0036
4205 Carbonic anhydrase 9 CA9 0.0035
3007 Carbonic anhydrase 12 CA12 0.0035
4200 Cytochrome P450 1A2 CYP1A2 0.0034
6126 Carbonic anhydrase 7 CA7 0.0033
833 Organic cation/carnitine transporter 1 SLC22A4 0.0031
4512 Cytochrome P450 3A4 CYP3A4 0.0029
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0029
5641 Rod shape-determining protein MreB TM_0588 0.0029
3794 Osmolarity sensor protein envZ envZ 0.0029
5644 Sensor protein phoQ phoQ 0.0029
5643 General secretion pathway protein E epsE 0.0029
5645 DNA topoisomerase 4 subunit B parE 0.0029
6227 DNA topoisomerase 4 subunit B parE 0.0029
5649 Potassium-transporting ATPase B chain kdpB 0.0029
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0029
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0029
5642 Chaperone clpB clpB 0.0029
6144 Solute carrier family 22 member 2 SLC22A2 0.0026
6145 Solute carrier family 22 member 1 SLC22A1 0.0026
2282 Protein recA recA 0.0025
2315 Protein recA recA 0.0025
2332 Protein recA recA 0.0025
5263 Protein recA recA 0.0025
740 Argininosuccinate synthase ASS1 0.0025
865 Argininosuccinate synthase ASS1 0.0025
2680 Argininosuccinate synthase argG 0.0025
3194 Argininosuccinate synthase argG 0.0025
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0025
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0025
4751 Mitogen-activated protein kinase 12 MAPK12 0.0025
5646 Galactokinase GALK1 0.0025
2852 DNA mismatch repair protein mutL mutL 0.0025
5265 FtsH ftsH 0.0025
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0025
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0025
5302 TrwB trwB 0.0025
2397 Dihydroxyacetone kinase dhaK 0.0025
592 Carbonic anhydrase 4 CA4 0.0025
295 Carbonic anhydrase 1 CA1 0.0025
357 Carbonic anhydrase 2 CA2 0.0025
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0023
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0023
3231 Death-associated protein kinase 1 DAPK1 0.0023
5312 Kinesin-like protein KIF1A KIF1A 0.0023
2892 Acetylglutamate kinase argB 0.0022
3550 Acetylglutamate kinase argB 0.0022
2371 Pantothenate kinase coaA 0.0022
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0022
2615 Chemotaxis protein cheA cheA 0.0022
825 Arsenical pump-driving ATPase ASNA1 0.0022
3435 Arsenical pump-driving ATPase arsA 0.0022
1881 Hexokinase-1 HK1 0.0022
1024 Solute carrier family 22 member 11 SLC22A11 0.0022
2727 S-adenosylmethionine synthetase metK 0.0021
887 DNA gyrase subunit B gyrB 0.0021
4150 DNA gyrase subunit B gyrB 0.0021
6225 DNA gyrase subunit B gyrB 0.0021
936 Ephrin type-A receptor 2 EPHA2 0.0021
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.002
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.002
958 Insulin-like growth factor 1 receptor IGF1R 0.0019
2251 Thymidylate kinase tmk 0.0018
2254 Thymidylate kinase DTYMK 0.0018
3522 Thymidylate kinase tmk 0.0018
1729 Solute carrier family 22 member 6 SLC22A6 0.0018
6013 Cytochrome P450 2E1 CYP2E1 0.0018
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0017
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0017
1836 Mitogen-activated protein kinase 10 MAPK10 0.0017
4192 DNA topoisomerase 2-beta TOP2B 0.0016
207 Glutathione synthetase GSS 0.0016
5269 Glutathione synthetase gshB 0.0016
1721 Glycogen synthase kinase-3 beta GSK3B 0.0016
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0016
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