DT-Web

DB03068 - Zebularine


Identification
Name Zebularine
Accession Number DB03068 (EXPT03280)
Type small molecule
Description A chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 228.202
Groups experimental
Monoisotopic Weight 228.074621504
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Cytidine deaminase
Name Cytidine deaminase
Gene Name cdd
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 2

Predictions


Id Partner name Gene Name Score
3611 Cytidine deaminase cdd 2
4211 Cytidine deaminase CDA 2
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