DT-Web

DB02877 - TTNPB


Identification
Name TTNPB
Accession Number DB02877 (EXPT03128)
Type small molecule
Description TTNPB is a retinoic acid analog which acts as a selective RAR agonist.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 348.4779
Groups experimental
Monoisotopic Weight 348.20893014
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Retinoic acid receptor beta
Name Retinoic acid receptor beta
Gene Name RARB
Pharmacological action unknown
Actions Not Available
References
  • Alvarez R, Vega MJ, Kammerer S, Rossin A, Germain P, Gronemeyer H, de Lera AR: 9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6117-22. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4849

Predictions


Id Partner name Gene Name Score
730 Retinoic acid receptor alpha RARA 0.2399
162 Retinoic acid receptor gamma-1 RARG 0.123
88 Retinoic acid receptor RXR-beta RXRB 0.1117
780 Retinoic acid receptor RXR-gamma RXRG 0.0888
459 Retinoic acid receptor RXR-alpha RXRA 0.0785
5934 Cytochrome P450 26A1 CYP26A1 0.0427
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0421
331 Retinol-binding protein I, cellular RBP1 0.0251
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0195
4924 Cytochrome P450 2C8 CYP2C8 0.0165
3811 Cytochrome P450 19A1 CYP19A1 0.0126
587 Serum albumin ALB 0.01
4200 Cytochrome P450 1A2 CYP1A2 0.0078
1588 Multidrug resistance protein 1 ABCB1 0.0076
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