DT-Web

DB02588 - Moxalactam Derivative


Identification
Name Moxalactam Derivative
Accession Number DB02588 (EXPT02215)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 406.3435
Groups experimental
Monoisotopic Weight 406.101230184
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions
Drug Mechanism of interaction
Probenecid Probenecid may increase the serum level of the moxalactam derivative.
Food Interactions Not Available

Targets


Beta-lactamase
Name Beta-lactamase
Gene Name ampC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.6209

Predictions


Id Partner name Gene Name Score
332 Beta-lactamase blaZ 1.6209
2613 Beta-lactamase ampC 1.6209
2635 Beta-lactamase ampC 1.6209
2700 Beta-lactamase penP 1.6209
5445 Beta-lactamase blaB 1.6209
6019 Beta-lactamase SHV-7 1.6209
6701 Beta-lactamase cphA 1.6209
4629 Beta-lactamase CTX-M-9a blaCTX-M-9a 0.0803
2858 Beta-lactamase TEM bla 0.0383
6396 Beta-lactamase TEM bla 0.0383
3010 Regulatory protein blaR1 blaR1 0.0365
4812 Extended-spectrum beta-lactamase CTX-M-14 blaCTX-M-14 0.0316
3195 Beta-lactamase Toho-1 bla 0.0244
645 Penicillin-binding protein 1A mrcA 0.0152
5805 Penicillin-binding protein 1A ponA 0.0152
6185 Penicillin-binding protein 1A mrcA 0.0152
6799 Penicillin-binding protein 1A pbpA 0.0152
4252 Penicillin-binding protein 5 dacA 0.0082
633 Penicillin-binding proteins 1A/1B pbpA 0.0067
159 Penicillin-binding protein 2B penA 0.0066
6121 Penicillin-binding protein 2B penA 0.0066
4810 Beta-glucosidase bgl3 0.0061
4816 Orange carotenoid-binding protein Not Available 0.0061
4748 Levansucrase sacB 0.0061
4817 Sucrose porin scrY 0.0061
4818 Beta-lactamase CTX-M-27 blaCTX-M-27 0.0061
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0057
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0055
4813 Heme oxygenase hmuO 0.0053
5769 Heme oxygenase Not Available 0.0053
4814 Copper transport protein ATOX1 ATOX1 0.0053
2780 Septum formation protein Maf maf 0.0053
587 Serum albumin ALB 0.0049
3367 GDP-mannose 6-dehydrogenase algD 0.0049
4811 Amylosucrase ams 0.0049
1729 Solute carrier family 22 member 6 SLC22A6 0.0048
2617 Nitric oxide synthase oxygenase nos 0.0046
2701 Nitric oxide synthase oxygenase nos 0.0046
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0038
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0038
3822 Actin, alpha skeletal muscle ACTA1 0.0036
543 Penicillin-binding protein 1B mrcB 0.0027
6186 Penicillin-binding protein 1B ponB 0.0027
6822 Penicillin-binding protein 1b pbp1b 0.0027
6844 Penicillin-binding protein 1b pbp1b 0.0027
1024 Solute carrier family 22 member 11 SLC22A11 0.0022
6143 Solute carrier family 22 member 7 SLC22A7 0.0021
118 Organic cation/carnitine transporter 2 SLC22A5 0.002
6142 Solute carrier family 22 member 8 SLC22A8 0.0019
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