DT-Web

DB02491 - 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine


Identification
Name 4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine
Accession Number DB02491 (EXPT00378)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 451.992
Groups experimental
Monoisotopic Weight 451.213888314
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Fibroblast growth factor receptor 2
Name Fibroblast growth factor receptor 2
Gene Name FGFR2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5727

Predictions


Id Partner name Gene Name Score
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.2013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0755
3856 Fibroblast growth factor receptor 3 FGFR3 0.0709
1585 Basement membrane-specific heparan sulfate proteoglycan core protein HSPG2 0.0676
3852 Neuropilin-1 NRP1 0.0589
5787 Angiopoietin-1 receptor TEK 0.0254
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0243
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.023
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0218
504 Mast/stem cell growth factor receptor KIT 0.0193
777 Tumor necrosis factor TNF 0.0191
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0186
407 Vascular endothelial growth factor receptor 2 KDR 0.0184
5798 Mitogen-activated protein kinase 11 MAPK11 0.0153
6824 Tyrosine-protein kinase Lyn LYN 0.0146
4118 Cytochrome P450 3A5 CYP3A5 0.0146
6016 Cytochrome P450 2C19 CYP2C19 0.0132
4757 Cytochrome P450 2C9 CYP2C9 0.0126
165 FL cytokine receptor FLT3 0.0125
290 Prostaglandin G/H synthase 2 PTGS2 0.0118
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0115
20 Prostaglandin G/H synthase 1 PTGS1 0.0112
936 Ephrin type-A receptor 2 EPHA2 0.0112
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.011
6024 Cytochrome P450 1A1 CYP1A1 0.0107
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0107
1618 High affinity nerve growth factor receptor NTRK1 0.0103
6013 Cytochrome P450 2E1 CYP2E1 0.0103
26 Vascular endothelial growth factor receptor 3 FLT4 0.0103
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0101
32 Vascular endothelial growth factor receptor 1 FLT1 0.01
4924 Cytochrome P450 2C8 CYP2C8 0.0092
228 Beta platelet-derived growth factor receptor PDGFRB 0.0091
4200 Cytochrome P450 1A2 CYP1A2 0.009
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0085
1588 Multidrug resistance protein 1 ABCB1 0.0085
4512 Cytochrome P450 3A4 CYP3A4 0.0074
776 Bile salt export pump ABCB11 0.0069
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0063
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0059
6030 Cytochrome P450 2B6 CYP2B6 0.0046
4119 Cytochrome P450 2D6 CYP2D6 0.0045
↑