DT-Web

DB01933 - 7-Hydroxystaurosporine


Identification
Name 7-Hydroxystaurosporine
Accession Number DB01933 (EXPT03167)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 482.5304
Groups experimental
Monoisotopic Weight 482.19540534
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


3-phosphoinositide-dependent protein kinase 1
Name 3-phosphoinositide-dependent protein kinase 1
Gene Name PDPK1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2092

Predictions


Id Partner name Gene Name Score
6392 Myotonin-protein kinase DMPK 0.1064
6391 Protein kinase C iota type PRKCI 0.071
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0531
2379 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide DAPP1 0.0303
2355 Tyrosine-protein kinase BTK BTK 0.0303
2348 Pleckstrin homology domain-containing family A member 4 PLEKHA4 0.0302
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0231
2530 Protein kinase C theta type PRKCQ 0.0226
4534 Cytohesin-2 CYTH2 0.0219
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0188
2473 Tyrosine-protein kinase CSK CSK 0.0164
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0164
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0143
3602 Anti-sigma F factor antagonist spoIIAA 0.0118
2514 Phosphocarrier protein HPr ptsH 0.0118
5689 Phosphocarrier protein HPr ptsH 0.0118
5686 Potassium voltage-gated channel subfamily C member 4 KCNC4 0.0118
2408 Tyrosine-protein kinase SYK SYK 0.0114
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0109
1130 Lithostathine 1 alpha REG1A 0.0102
4542 Glutaminase 1 glsA1 0.0102
4544 Glutaminase 1 glsA1 0.0102
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.01
4318 Siroheme synthase cysG 0.0096
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0095
3119 Fimbrial protein pilE1 0.0095
3453 Alkaline phosphatase phoA 0.0089
1721 Glycogen synthase kinase-3 beta GSK3B 0.0088
5150 Endo-1,4-beta-xylanase Y xynY 0.0086
2503 Phosphomannomutase/phosphoglucomutase algC 0.0085
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0082
2164 Multidrug resistance-associated protein 4 ABCC4 0.0077
290 Prostaglandin G/H synthase 2 PTGS2 0.0073
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0068
10 Glycogen phosphorylase, liver form PYGL 0.0067
2207 Rhodopsin RHO 0.0066
587 Serum albumin ALB 0.0065
2240 Cell division protein kinase 2 CDK2 0.0061
4924 Cytochrome P450 2C8 CYP2C8 0.0058
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0056
1152 Glycogen phosphorylase, muscle form PYGM 0.0054
4757 Cytochrome P450 2C9 CYP2C9 0.0053
4119 Cytochrome P450 2D6 CYP2D6 0.0052
4512 Cytochrome P450 3A4 CYP3A4 0.0047
1588 Multidrug resistance protein 1 ABCB1 0.0037
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