DT-Web

DB01830 - {4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic Acid


Identification
Name {4-[2-Acetylamino-2-(3-Carbamoyl-2-Cyclohexylmethoxy-6,7,8,9-Tetrahydro-5h-Benzocyclohepten-5ylcarbamoyl)-Ethyl]-2-Phosphono-Phenyl}-Phosphonic Acid
Accession Number DB01830 (EXPT00856)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 665.6082
Groups experimental
Monoisotopic Weight 665.226717571
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Proto-oncogene tyrosine-protein kinase LCK
Name Proto-oncogene tyrosine-protein kinase LCK
Gene Name LCK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2545

Predictions


Id Partner name Gene Name Score
6824 Tyrosine-protein kinase Lyn LYN 0.068
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0441
2473 Tyrosine-protein kinase CSK CSK 0.0164
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0163
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0143
2530 Protein kinase C theta type PRKCQ 0.0131
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0121
504 Mast/stem cell growth factor receptor KIT 0.012
936 Ephrin type-A receptor 2 EPHA2 0.0118
2408 Tyrosine-protein kinase SYK SYK 0.0114
1721 Glycogen synthase kinase-3 beta GSK3B 0.0113
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0112
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0108
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0099
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0095
2216 Fibroblast growth factor receptor 4 FGFR4 0.009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0089
1588 Multidrug resistance protein 1 ABCB1 0.0088
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0083
3856 Fibroblast growth factor receptor 3 FGFR3 0.0082
1063 Signal transducer and activator of transcription 5B STAT5B 0.008
5787 Angiopoietin-1 receptor TEK 0.0077
484 Tyrosine-protein kinase ABL2 ABL2 0.0074
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0067
823 Fibroblast growth factor receptor 2 FGFR2 0.0067
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0066
228 Beta platelet-derived growth factor receptor PDGFRB 0.0065
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0064
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0063
165 FL cytokine receptor FLT3 0.0062
2240 Cell division protein kinase 2 CDK2 0.0061
407 Vascular endothelial growth factor receptor 2 KDR 0.0054
4118 Cytochrome P450 3A5 CYP3A5 0.0054
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0053
5643 General secretion pathway protein E epsE 0.0046
5641 Rod shape-determining protein MreB TM_0588 0.0046
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0046
5649 Potassium-transporting ATPase B chain kdpB 0.0046
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0046
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0046
3794 Osmolarity sensor protein envZ envZ 0.0046
5644 Sensor protein phoQ phoQ 0.0046
5642 Chaperone clpB clpB 0.0046
5645 DNA topoisomerase 4 subunit B parE 0.0046
6227 DNA topoisomerase 4 subunit B parE 0.0046
4512 Cytochrome P450 3A4 CYP3A4 0.0044
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0041
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0041
2282 Protein recA recA 0.0041
2315 Protein recA recA 0.0041
2332 Protein recA recA 0.0041
5263 Protein recA recA 0.0041
5646 Galactokinase GALK1 0.0041
5302 TrwB trwB 0.0041
5265 FtsH ftsH 0.0041
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.004
4751 Mitogen-activated protein kinase 12 MAPK12 0.004
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.004
2852 DNA mismatch repair protein mutL mutL 0.004
740 Argininosuccinate synthase ASS1 0.004
865 Argininosuccinate synthase ASS1 0.004
2680 Argininosuccinate synthase argG 0.004
3194 Argininosuccinate synthase argG 0.004
2397 Dihydroxyacetone kinase dhaK 0.004
1898 Cytochrome P450 1B1 CYP1B1 0.0039
5312 Kinesin-like protein KIF1A KIF1A 0.0037
3231 Death-associated protein kinase 1 DAPK1 0.0037
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0037
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0037
2892 Acetylglutamate kinase argB 0.0035
3550 Acetylglutamate kinase argB 0.0035
2615 Chemotaxis protein cheA cheA 0.0035
2371 Pantothenate kinase coaA 0.0035
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0035
1881 Hexokinase-1 HK1 0.0035
825 Arsenical pump-driving ATPase ASNA1 0.0035
3435 Arsenical pump-driving ATPase arsA 0.0035
776 Bile salt export pump ABCB11 0.0035
2727 S-adenosylmethionine synthetase metK 0.0034
887 DNA gyrase subunit B gyrB 0.0033
4150 DNA gyrase subunit B gyrB 0.0033
6225 DNA gyrase subunit B gyrB 0.0033
6024 Cytochrome P450 1A1 CYP1A1 0.0033
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0032
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0032
958 Insulin-like growth factor 1 receptor IGF1R 0.003
2251 Thymidylate kinase tmk 0.0029
2254 Thymidylate kinase DTYMK 0.0029
3522 Thymidylate kinase tmk 0.0029
4200 Cytochrome P450 1A2 CYP1A2 0.0027
3822 Actin, alpha skeletal muscle ACTA1 0.0027
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0027
1836 Mitogen-activated protein kinase 10 MAPK10 0.0026
207 Glutathione synthetase GSS 0.0026
5269 Glutathione synthetase gshB 0.0026
4192 DNA topoisomerase 2-beta TOP2B 0.0026
4924 Cytochrome P450 2C8 CYP2C8 0.0025
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
4119 Cytochrome P450 2D6 CYP2D6 0.0023
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