DT-Web

DB01422 - Nitroxoline


Identification
Name Nitroxoline
Accession Number DB01422
Type small molecule
Description Nitroxoline is a urinary antibacterial agent active against susceptible gram-positive and gram-negative organisms commonly found in urinary tract infections. It is a fluorquinolone that is active against bacterial gyrases.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 190.1555
Groups approved
Monoisotopic Weight 190.037842068
Pharmacology
Indication Nitroxoline is an antibiotic agent.
Mechanism of action This drug may also have antitumor activity by inhibition of ype 2 methionine aminopeptidase (MetAP2) protein which is involved in angiogenesis. Its antibacterial activity may stem from the metal ion complexation vital for bacterial growth.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Methionine aminopeptidase 1
Name Methionine aminopeptidase 1
Gene Name METAP1
Pharmacological action yes
Actions inhibitor
References
  • Shim JS, Matsui Y, Bhat S, Nacev BA, Xu J, Bhang HE, Dhara S, Han KC, Chong CR, Pomper MG, So A, Liu JO: Effect of nitroxoline on angiogenesis and growth of human bladder cancer. J Natl Cancer Inst. 2010 Dec 15;102(24):1855-73. Epub 2010 Nov 18. - Pubmed
DTHybrid score 1.6248
Magnesium
Name Magnesium
Gene Name Not Available
Pharmacological action unknown
Actions chelator
References
  • Pelletier C, Prognon P, Latrache H, Villart L, Bourlioux P: [Microbiological consequences of chelation of bivalent metal cations by nitroxoline]. Pathol Biol (Paris). 1994 May;42(5):406-11. - Pubmed
  • Pelletier C, Prognon P, Bourlioux P: Roles of divalent cations and pH in mechanism of action of nitroxoline against Escherichia coli strains. Antimicrob Agents Chemother. 1995 Mar;39(3):707-13. - Pubmed
DTHybrid score Not Available
manganese
Name manganese
Gene Name Not Available
Pharmacological action unknown
Actions chelator
References
  • Pelletier C, Prognon P, Latrache H, Villart L, Bourlioux P: [Microbiological consequences of chelation of bivalent metal cations by nitroxoline]. Pathol Biol (Paris). 1994 May;42(5):406-11. - Pubmed
  • Pelletier C, Prognon P, Bourlioux P: Roles of divalent cations and pH in mechanism of action of nitroxoline against Escherichia coli strains. Antimicrob Agents Chemother. 1995 Mar;39(3):707-13. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
2795 Methionine aminopeptidase 2 METAP2 0.1224
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