DT-Web

DB01284 - Cosyntropin


Identification
Name Cosyntropin
Accession Number DB01284
Type biotech
Description A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 2933.4370
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For use as a diagnostic agent in the screening of patients presumed to have adrenocortical insufficiency.
Mechanism of action Cosyntropin combines with a specific receptor in the adrenal cell plasma membrane and, in patients with normal adrenocortical function, stimulates the initial reaction involved in the synthesis of adrenal steroids (including cortisol, cortisone, weak androgenic substances, and a limited quantity of aldosterone) from cholesterol by increasing the quantity of the substrate within the mitochondria. Cosyntropin does not significantly increase plasma cortisol concentration in patients with primary or secondary adrenocortical insufficiency.
Absorption Rapidly absorbed following intramuscular administration.
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Adrenocorticotropic hormone receptor
Name Adrenocorticotropic hormone receptor
Gene Name MC2R
Pharmacological action yes
Actions antagonist
References
  • Schwerin M, Kanitz E, Tuchscherer M, Brussow KP, Nurnberg G, Otten W: Stress-related gene expression in brain and adrenal gland of porcine fetuses and neonates. Theriogenology. 2005 Mar 1;63(4):1220-34. - Pubmed
  • Mehrabani PA, Bassett JR: Adrenocorticotropin binding sites in rat cardiac tissue. Pharmacol Biochem Behav. 1990 Jan;35(1):99-103. - Pubmed
  • Moraes RB, Czepielewski MA, Friedman G: Cortisol variation after low-dose Cortrosyn test. Crit Care Med. 2010 Jul;38(7):1612-3. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.2

Predictions


Id Partner name Gene Name Score
1566 Corticoliberin CRH 0.1571
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.1483
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.1483
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.1368
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