DB01152 - Candicidin
| Identification | |
|---|---|
| Name | Candicidin |
| Accession Number | DB01152 (APRD00843) |
| Type | small molecule |
| Description | Candicidin is an antibiotic obtained from a streptomyces (Streptomyces griseus) and active against some fungi of the genus Candida (C. albicans). Candicidin is administered intravaginally in the treatment of vulvovaginal candidiasis. |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 1109.3009 |
| Groups | approved |
| Monoisotopic Weight | 1108.571913894 |
| Pharmacology | |
| Indication | Used in the topical treatment of vulvovaginal candidiasis. |
| Mechanism of action | Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of Candicidin. Candicidin binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. There is some evidence that the binding site in the cell wall may be to fatty acids or fatty acid esters and that this binding capacity must be satisfied before candicidin can bring about its lethal effect by binding to sterol in the cell membrane. |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Ergosterol, Candida albicans | |
|---|---|
| Name | Ergosterol, Candida albicans |
| Gene Name | Not Available |
| Pharmacological action | yes |
| Actions | antagonist |
| References |
|
| DTHybrid score | Not Available |
Predictions
| Id | Partner name | Gene Name | Score |
|---|