DT-Web

DB01123 - Proflavine


Identification
Name Proflavine
Accession Number DB01123 (APRD00535)
Type small molecule
Description 3,6-Diaminoacridine. Topical antiseptic used mainly in wound dressings. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 209.2465
Groups approved
Monoisotopic Weight 209.095297367
Pharmacology
Indication Topical antiseptic used mainly in wound dressings.
Mechanism of action Proflavine acts by interchelating DNA (intercalation), thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands. This prevents bacterial reproduction.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions intercalation
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Sinha R, Hossain M, Kumar GS: Interaction of small molecules with double-stranded RNA: spectroscopic, viscometric, and calorimetric study of hoechst and proflavine binding to PolyCG structures. DNA Cell Biol. 2009 Apr;28(4):209-19. - Pubmed
  • Berezniak EG, gladkovskaia NA, Khrebtova AS, Dukhopel'nikov EV, Zinchenko AV: [Features of binding of proflavine to DNA at different DNA-ligand concentration ratios] Biofizika. 2009 Sep-Oct;54(5):805-12. - Pubmed
DTHybrid score Not Available
Prothrombin
Name Prothrombin
Gene Name F2
Pharmacological action no
Actions other/unknown
References
  • Sie P, Bezeaud A, Dupouy D, Archipoff G, Freyssinet JM, Dugoujon JM, Serre G, Guillin MC, Boneu B: An acquired antithrombin autoantibody directed toward the catalytic center of the enzyme. J Clin Invest. 1991 Jul;88(1):290-6. - Pubmed
  • Koehler KA, Magnusson S: The binding of proflavin to thrombin. Arch Biochem Biophys. 1974 Jan;160(1):175-84. - Pubmed
  • Sonder SA, Fenton JW 2nd: Proflavin binding within the fibrinopeptide groove adjacent to the catalytic site of human alpha-thrombin. Biochemistry. 1984 Apr 10;23(8):1818-23. - Pubmed
  • Valeri AM, Wilson SM, Feinman RD: Reaction of antithrombin with proteases. Evidence for a specific reaction with papain. Biochim Biophys Acta. 1980 Aug 7;614(2):526-33. - Pubmed
  • De Cristofaro R, De Candia E, Picozzi M, Landolfi R: Conformational transitions linked to active site ligation in human thrombin: effect on the interaction with fibrinogen and the cleavable platelet receptor. J Mol Biol. 1995 Jan 27;245(4):447-58. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.8003
HTH-type transcriptional regulator qacR
Name HTH-type transcriptional regulator qacR
Gene Name qacR
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.2728
TetR family transcriptional repressor LfrR
Name TetR family transcriptional repressor LfrR
Gene Name lfrR
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.859

Predictions


Id Partner name Gene Name Score
2331 HTH-type transcriptional regulator qacR qacR 0.2728
3176 Trypsin-1 PRSS1 0.1672
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.1164
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.1164
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.1124
239 Coagulation factor X F10 0.0394
1074 Urokinase-type plasminogen activator PLAU 0.0362
369 Coagulation factor VII F7 0.0173
3119 Fimbrial protein pilE1 0.0168
6564 Prephenate dehydrogenase tyrA 0.0122
6240 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 0.0122
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0093
3384 Macrophage migration inhibitory factor MIF 0.009
19 Coagulation factor VIII F8 0.0083
1757 Myeloperoxidase MPO 0.0083
798 Osteocalcin BGLAP 0.008
3831 Low-density lipoprotein receptor-related protein 1 LRP1 0.0075
3851 Serine protease hepsin HPN 0.0071
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0064
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0049
4757 Cytochrome P450 2C9 CYP2C9 0.0048
4165 P2Y purinoceptor 2 P2RY2 0.0047
400 Coagulation factor IX F9 0.0039
5461 Coagulation factor IX F9 0.0039
1547 Coagulation factor XI F11 0.0039
2654 Complement control protein C3L 0.0037
1959 Platelet factor 4 PF4 0.0035
3865 Serpin B6 SERPINB6 0.0035
1986 Ceruloplasmin CP 0.0035
1245 Vitamin K-dependent protein S PROS1 0.0035
4118 Cytochrome P450 3A5 CYP3A5 0.0035
430 Follicle-stimulating hormone receptor FSHR 0.0034
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0034
422 Vitamin K-dependent protein C PROC 0.0033
3842 Multiple coagulation factor deficiency protein 2 MCFD2 0.0033
3841 ERGIC-53 protein LMAN1 0.0033
3840 Asialoglycoprotein receptor 2 ASGR2 0.0033
1847 78 kDa glucose-regulated protein HSPA5 0.0033
1635 von Willebrand factor VWF 0.0033
5455 Arylsulfatase A ARSA 0.0032
3833 Plasma serine protease inhibitor SERPINA5 0.0031
4604 Liver carboxylesterase 1 CES1 0.0031
2072 Endothelial protein C receptor PROCR 0.0031
46 Coagulation factor V F5 0.0031
814 Ryanodine receptor 1 RYR1 0.0029
4512 Cytochrome P450 3A4 CYP3A4 0.0028
1516 Calnexin CANX 0.0028
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0027
2981 Phospholipase A2, membrane associated PLA2G2A 0.0026
2021 Thrombomodulin THBD 0.0026
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0025
3830 Calreticulin CALR 0.0023
3839 Phytanoyl-CoA dioxygenase, peroxisomal PHYH 0.0023
267 Plasminogen activator inhibitor 1 SERPINE1 0.0023
723 Cytosolic phospholipase A2 PLA2G4A 0.0023
1588 Multidrug resistance protein 1 ABCB1 0.0016
604 Vitamin K-dependent protein Z PROZ 0.0014
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0014
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.001
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.001
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
6020 Aldehyde oxidase AOX1 0.0009
3947 Xanthine dehydrogenase/oxidase XDH 0.0008
5718 Cytochrome P450 2A6 CYP2A6 0.0006
6024 Cytochrome P450 1A1 CYP1A1 0.0006
6013 Cytochrome P450 2E1 CYP2E1 0.0006
4200 Cytochrome P450 1A2 CYP1A2 0.0005
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