DT-Web

DB01108 - Trilostane


Identification
Name Trilostane
Accession Number DB01108 (APRD01276)
Type small molecule
Description Trilostane is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. It was withdrawn from the United States market in April 1994. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 329.4333
Groups approved
Monoisotopic Weight 329.199093735
Pharmacology
Indication Used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
Mechanism of action Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
Absorption Not Available
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I
Name 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I
Gene Name HSD3B1
Pharmacological action yes
Actions inhibitor
References
  • Naville D, Keeney DS, Jenkin G, Murry BA, Head JR, Mason JI: Regulation of expression of male-specific rat liver microsomal 3 beta-hydroxysteroid dehydrogenase. Mol Endocrinol. 1991 Aug;5(8):1090-100. - Pubmed
  • Takahashi M, Luu-The V, Labrie F: Inhibitory effect of synthetic progestins, 4-MA and cyanoketone on human placental 3 beta-hydroxysteroid dehydrogenase/5----4-ene-isomerase activity. J Steroid Biochem Mol Biol. 1990 Oct;37(2):231-6. - Pubmed
  • Suzuki S, Endo Y, Tanaka S, Iizuka R: Indirect immunofluorescence studies on the steroid-producing activity of hamster ova. Am J Obstet Gynecol. 1984 Jan 1;148(1):76-85. - Pubmed
  • Duffy DM, Hess DL, Stouffer RL: Acute administration of a 3 beta-hydroxysteroid dehydrogenase inhibitor to rhesus monkeys at the midluteal phase of the menstrual cycle: evidence for possible autocrine regulation of the primate corpus luteum by progesterone. J Clin Endocrinol Metab. 1994 Dec;79(6):1587-94. - Pubmed
  • Mensah-Nyagan AG, Feuilloley M, Dupont E, Do-Rego JL, Leboulenger F, Pelletier G, Vaudry H: Immunocytochemical localization and biological activity of 3 beta-hydroxysteroid dehydrogenase in the central nervous system of the frog. J Neurosci. 1994 Dec;14(12):7306-18. - Pubmed
  • Cooke GM: Differential effects of trilostane and cyanoketone on the 3 beta-hydroxysteroid dehydrogenase-isomerase reactions in androgen and 16-androstene biosynthetic pathways in the pig testis. J Steroid Biochem Mol Biol. 1996 Apr;58(1):95-101. - Pubmed
  • Igaz P, Tombol Z, Szabo PM, Liko I, Racz K: Steroid biosynthesis inhibitors in the therapy of hypercortisolism: theory and practice. Curr Med Chem. 2008;15(26):2734-47. - Pubmed
DTHybrid score 0.4054
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
Name 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
Gene Name HSD3B2
Pharmacological action yes
Actions inhibitor
References
  • Naville D, Keeney DS, Jenkin G, Murry BA, Head JR, Mason JI: Regulation of expression of male-specific rat liver microsomal 3 beta-hydroxysteroid dehydrogenase. Mol Endocrinol. 1991 Aug;5(8):1090-100. - Pubmed
  • Cooke GM: Differential effects of trilostane and cyanoketone on the 3 beta-hydroxysteroid dehydrogenase-isomerase reactions in androgen and 16-androstene biosynthetic pathways in the pig testis. J Steroid Biochem Mol Biol. 1996 Apr;58(1):95-101. - Pubmed
  • Takahashi M, Luu-The V, Labrie F: Inhibitory effect of synthetic progestins, 4-MA and cyanoketone on human placental 3 beta-hydroxysteroid dehydrogenase/5----4-ene-isomerase activity. J Steroid Biochem Mol Biol. 1990 Oct;37(2):231-6. - Pubmed
  • Suzuki S, Endo Y, Tanaka S, Iizuka R: Indirect immunofluorescence studies on the steroid-producing activity of hamster ova. Am J Obstet Gynecol. 1984 Jan 1;148(1):76-85. - Pubmed
  • Duffy DM, Hess DL, Stouffer RL: Acute administration of a 3 beta-hydroxysteroid dehydrogenase inhibitor to rhesus monkeys at the midluteal phase of the menstrual cycle: evidence for possible autocrine regulation of the primate corpus luteum by progesterone. J Clin Endocrinol Metab. 1994 Dec;79(6):1587-94. - Pubmed
  • Mensah-Nyagan AG, Feuilloley M, Dupont E, Do-Rego JL, Leboulenger F, Pelletier G, Vaudry H: Immunocytochemical localization and biological activity of 3 beta-hydroxysteroid dehydrogenase in the central nervous system of the frog. J Neurosci. 1994 Dec;14(12):7306-18. - Pubmed
  • Igaz P, Tombol Z, Szabo PM, Liko I, Racz K: Steroid biosynthesis inhibitors in the therapy of hypercortisolism: theory and practice. Curr Med Chem. 2008;15(26):2734-47. - Pubmed
DTHybrid score 0.4402
Estrogen receptor
Name Estrogen receptor
Gene Name ESR1
Pharmacological action yes
Actions allosteric modulator
References
  • Puddefoot JR, Barker S, Vinson GP: Trilostane in advanced breast cancer. Expert Opin Pharmacother. 2006 Dec;7(17):2413-9. - Pubmed
  • Puddefoot JR, Barker S, Glover HR, Malouitre SD, Vinson GP: Non-competitive steroid inhibition of oestrogen receptor functions. Int J Cancer. 2002 Sep 1;101(1):17-22. - Pubmed
  • Barker S, Malouitre SD, Glover HR, Puddefoot JR, Vinson GP: Comparison of effects of 4-hydroxy tamoxifen and trilostane on oestrogen-regulated gene expression in MCF-7 cells: up-regulation of oestrogen receptor beta. J Steroid Biochem Mol Biol. 2006 Aug;100(4-5):141-51. Epub 2006 Jun 27. - Pubmed
DTHybrid score 0.9316
Estrogen receptor beta
Name Estrogen receptor beta
Gene Name ESR2
Pharmacological action yes
Actions allosteric modulator
References
  • Puddefoot JR, Barker S, Vinson GP: Trilostane in advanced breast cancer. Expert Opin Pharmacother. 2006 Dec;7(17):2413-9. - Pubmed
  • Puddefoot JR, Barker S, Glover HR, Malouitre SD, Vinson GP: Non-competitive steroid inhibition of oestrogen receptor functions. Int J Cancer. 2002 Sep 1;101(1):17-22. - Pubmed
  • Barker S, Malouitre SD, Glover HR, Puddefoot JR, Vinson GP: Comparison of effects of 4-hydroxy tamoxifen and trilostane on oestrogen-regulated gene expression in MCF-7 cells: up-regulation of oestrogen receptor beta. J Steroid Biochem Mol Biol. 2006 Aug;100(4-5):141-51. Epub 2006 Jun 27. - Pubmed
DTHybrid score 1.0462

Predictions


Id Partner name Gene Name Score
6228 Nuclear receptor coactivator 1 NCOA1 0.2566
6241 Nuclear receptor coactivator 2 NCOA2 0.2355
614 Progesterone receptor PGR 0.1043
2972 6-deoxyerythronolide B hydroxylase eryF 0.1014
945 Adrenocorticotropic hormone receptor MC2R 0.0978
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0903
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0792
1566 Corticoliberin CRH 0.0717
4512 Cytochrome P450 3A4 CYP3A4 0.0699
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.0683
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0611
6560 Nuclear receptor coactivator 5 NCOA5 0.0526
756 Sex hormone-binding globulin SHBG 0.0474
4757 Cytochrome P450 2C9 CYP2C9 0.0466
4924 Cytochrome P450 2C8 CYP2C8 0.0424
3437 Eosinophil lysophospholipase CLC 0.0424
3811 Cytochrome P450 19A1 CYP19A1 0.0354
1588 Multidrug resistance protein 1 ABCB1 0.0352
2107 Microtubule-associated protein 1A MAP1A 0.0204
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0189
4200 Cytochrome P450 1A2 CYP1A2 0.0188
1852 Microtubule-associated protein 2 MAP2 0.0153
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0141
6020 Aldehyde oxidase AOX1 0.0131
6030 Cytochrome P450 2B6 CYP2B6 0.0128
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0118
373 Transthyretin TTR 0.0117
6024 Cytochrome P450 1A1 CYP1A1 0.0117
146 Androgen receptor AR 0.0115
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0109
587 Serum albumin ALB 0.0099
992 Protein tyrosine kinase 2 beta PTK2B 0.0095
381 Prolactin receptor PRLR 0.0093
6145 Solute carrier family 22 member 1 SLC22A1 0.0088
5718 Cytochrome P450 2A6 CYP2A6 0.0088
6013 Cytochrome P450 2E1 CYP2E1 0.0081
1898 Cytochrome P450 1B1 CYP1B1 0.0077
3809 Estrogen-related receptor gamma ESRRG 0.0076
6016 Cytochrome P450 2C19 CYP2C19 0.0073
3810 Catechol O-methyltransferase COMT 0.0068
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0066
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0066
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0066
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0066
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0066
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0066
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0066
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0066
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0066
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0066
816 Biliverdin reductase A BLVRA 0.0066
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0066
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0066
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0066
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0066
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0066
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0066
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0066
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0066
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0066
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0066
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0066
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0066
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0066
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0066
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0066
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0066
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0066
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0066
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0066
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0066
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0066
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0066
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0066
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0066
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0066
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0066
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0066
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0066
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0066
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0066
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0066
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0066
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0066
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0066
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0066
729 GDP-L-fucose synthetase TSTA3 0.0066
3463 GDP-L-fucose synthetase fcl 0.0066
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0066
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0066
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0066
206 3-keto-steroid reductase HSD17B7 0.0066
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0066
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0066
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0066
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0066
107 C-4 methylsterol oxidase SC4MOL 0.0066
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0066
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0066
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0066
3726 D-3-phosphoglycerate dehydrogenase serA 0.0066
4291 D-3-phosphoglycerate dehydrogenase serA 0.0066
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0066
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0066
167 L-lactate dehydrogenase C chain LDHC 0.0066
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0066
643 Peroxisomal bifunctional enzyme EHHADH 0.0066
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0066
711 UDP-glucose 6-dehydrogenase UGDH 0.0066
3672 UDP-glucose 6-dehydrogenase hasB 0.0066
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0066
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0066
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0066
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0066
644 Heme oxygenase 2 HMOX2 0.0066
4982 Heme oxygenase 2 pbsA2 0.0066
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0066
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0066
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0066
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0066
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0066
34 7-dehydrocholesterol reductase DHCR7 0.0066
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0066
862 Multidrug resistance-associated protein 1 ABCC1 0.0066
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0063
776 Bile salt export pump ABCB11 0.006
646 Malate dehydrogenase, cytoplasmic MDH1 0.0057
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0057
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0057
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0057
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0057
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0057
817 DNA topoisomerase 2-alpha TOP2A 0.0056
396 Alcohol dehydrogenase 4 ADH4 0.0056
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0056
666 NADP-dependent malic enzyme ME1 0.0056
6141 Sodium/bile acid cotransporter SLC10A1 0.0055
380 Cytochrome P450 17A1 CYP17A1 0.0055
328 Sorbitol dehydrogenase SORD 0.0055
597 Dihydropteridine reductase QDPR 0.0055
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0055
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0055
6026 Alcohol dehydrogenase 6 ADH6 0.0054
627 11-cis retinol dehydrogenase RDH5 0.0054
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0054
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0053
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0053
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0053
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0053
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0053
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0053
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0053
468 Cytochrome P450 4A11 CYP4A11 0.0053
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0053
626 Cysteine dioxygenase type 1 CDO1 0.0052
857 Malate dehydrogenase, mitochondrial MDH2 0.0052
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0052
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0051
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0051
569 Retinal dehydrogenase 2 ALDH1A2 0.005
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.005
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.005
77 L-lactate dehydrogenase B chain LDHB 0.005
12 Alcohol dehydrogenase class 3 ADH5 0.0049
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0049
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0048
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0048
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0048
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0048
13 Aminomethyltransferase, mitochondrial AMT 0.0048
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0047
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0047
4118 Cytochrome P450 3A5 CYP3A5 0.0047
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0047
473 L-lactate dehydrogenase A chain LDHA 0.0047
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0047
611 Retinal dehydrogenase 1 ALDH1A1 0.0046
1649 Small inducible cytokine A2 CCL2 0.0046
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0045
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0044
279 Tyrosinase TYR 0.0044
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0043
251 Alcohol dehydrogenase 1A ADH1A 0.0043
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0043
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0043
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0043
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0042
1192 Sulfotransferase 1A1 SULT1A1 0.0041
871 Glucocorticoid receptor NR3C1 0.0041
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.004
226 Gonadotropin-releasing hormone receptor GNRHR 0.004
654 Flavin reductase BLVRB 0.004
6107 Cytochrome P450 3A7 CYP3A7 0.004
810 Heme oxygenase 1 HMOX1 0.0038
3391 Heme oxygenase 1 pbsA1 0.0038
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0038
444 Alcohol dehydrogenase 1B ADH1B 0.0038
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0037
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0037
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0036
4210 Toll-like receptor 4 TLR4 0.0036
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0036
714 Glutathione reductase, mitochondrial GSR 0.0035
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0035
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0035
6142 Solute carrier family 22 member 8 SLC22A8 0.0034
1291 cAMP response element-binding protein CREB1 0.0033
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0033
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0033
517 Alcohol dehydrogenase 1C ADH1C 0.0032
6085 Fatty acid-binding protein, intestinal FABP2 0.0032
3947 Xanthine dehydrogenase/oxidase XDH 0.0031
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0031
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.003
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.003
6147 Solute carrier family 22 member 3 SLC22A3 0.003
365 Dihydrofolate reductase DHFR 0.0029
2381 Dihydrofolate reductase DFR1 0.0029
2833 Dihydrofolate reductase Not Available 0.0029
2931 Dihydrofolate reductase folA 0.0029
3544 Dihydrofolate reductase folA 0.0029
3682 Dihydrofolate reductase folA 0.0029
6642 Dihydrofolate reductase folA 0.0029
6756 Dihydrofolate reductase dfrA 0.0029
4604 Liver carboxylesterase 1 CES1 0.0028
822 Aldose reductase AKR1B1 0.0028
1024 Solute carrier family 22 member 11 SLC22A11 0.0027
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0027
6144 Solute carrier family 22 member 2 SLC22A2 0.0026
3830 Calreticulin CALR 0.0025
6035 Nuclear receptor ROR-beta RORB 0.0024
6034 Hydroxyindole O-methyltransferase ASMT 0.0024
6036 Eosinophil peroxidase EPX 0.0024
6148 Multidrug resistance-associated protein 7 ABCC10 0.0022
4119 Cytochrome P450 2D6 CYP2D6 0.0021
571 Melatonin receptor type 1A MTNR1A 0.0021
362 Melatonin receptor type 1B MTNR1B 0.0021
765 Indoleamine 2,3-dioxygenase IDO1 0.002
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.002
696 Kappa-type opioid receptor OPRK1 0.002
467 Delta-type opioid receptor OPRD1 0.002
847 Mu-type opioid receptor OPRM1 0.0019
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
465 Calmodulin CALM1 0.0013
1757 Myeloperoxidase MPO 0.0013
737 Mineralocorticoid receptor NR3C2 0.0012
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0012
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0011
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0009
2164 Multidrug resistance-associated protein 4 ABCC4 0.0008
1729 Solute carrier family 22 member 6 SLC22A6 0.0007
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