DT-Web

DB01090 - Pentolinium


Identification
Name Pentolinium
Accession Number DB01090 (APRD00038)
Type small molecule
Description A nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 240.428
Groups approved
Monoisotopic Weight 240.256549034
Pharmacology
Indication Used to produce controlled hypotension during surgical procedures and in hypertensive crises.
Mechanism of action Pentolinium binds to the nicotinic (ganglion) acetylcholine receptor. This receptor/channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. Blockage of the receptor leads to smooth muscle relaxation and vasodilaton.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Oral, mouse: LD50 = 512 mg/kg; Oral, rat: LD50 = 890 mg/kg.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Neuronal acetylcholine receptor subunit alpha-10
Name Neuronal acetylcholine receptor subunit alpha-10
Gene Name CHRNA10
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • McKay DB, Burkman AM: Nicotinic and nonnicotinic receptor-mediated actions of vinblastine. Proc Soc Exp Biol Med. 1993 Jul;203(3):372-6. - Pubmed
  • Cachelin AB, Rust G: Beta-subunits co-determine the sensitivity of rat neuronal nicotinic receptors to antagonists. Pflugers Arch. 1995 Jan;429(3):449-51. - Pubmed
DTHybrid score 0.4612
Neuronal acetylcholine receptor subunit alpha-3
Name Neuronal acetylcholine receptor subunit alpha-3
Gene Name CHRNA3
Pharmacological action yes
Actions antagonist
References
  • Cachelin AB, Rust G: Beta-subunits co-determine the sensitivity of rat neuronal nicotinic receptors to antagonists. Pflugers Arch. 1995 Jan;429(3):449-51. - Pubmed
DTHybrid score 0.5228
Neuronal acetylcholine receptor subunit beta-4
Name Neuronal acetylcholine receptor subunit beta-4
Gene Name CHRNB4
Pharmacological action yes
Actions antagonist
References
  • Cachelin AB, Rust G: Beta-subunits co-determine the sensitivity of rat neuronal nicotinic receptors to antagonists. Pflugers Arch. 1995 Jan;429(3):449-51. - Pubmed
DTHybrid score 0.4118

Predictions


Id Partner name Gene Name Score
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.1281
3923 Cholinesterase BCHE 0.1079
1075 Alkaline phosphatase, placental-like ALPPL2 0.1024
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0833
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0809
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0808
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.078
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0759
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.071
4512 Cytochrome P450 3A4 CYP3A4 0.0573
847 Mu-type opioid receptor OPRM1 0.0491
3811 Cytochrome P450 19A1 CYP19A1 0.0475
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0467
6107 Cytochrome P450 3A7 CYP3A7 0.0378
4119 Cytochrome P450 2D6 CYP2D6 0.0374
4118 Cytochrome P450 3A5 CYP3A5 0.0356
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.03
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0299
713 Sodium-dependent dopamine transporter SLC6A3 0.0296
474 Acetylcholinesterase ACHE 0.0247
6030 Cytochrome P450 2B6 CYP2B6 0.0238
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0227
6014 Cytochrome P450 2A13 CYP2A13 0.022
4924 Cytochrome P450 2C8 CYP2C8 0.0219
341 5-hydroxytryptamine 3 receptor HTR3A 0.0215
4200 Cytochrome P450 1A2 CYP1A2 0.0209
5718 Cytochrome P450 2A6 CYP2A6 0.0203
4757 Cytochrome P450 2C9 CYP2C9 0.0202
6013 Cytochrome P450 2E1 CYP2E1 0.0182
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0174
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0171
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0164
6016 Cytochrome P450 2C19 CYP2C19 0.0147
6147 Solute carrier family 22 member 3 SLC22A3 0.0144
833 Organic cation/carnitine transporter 1 SLC22A4 0.0144
3941 Amine oxidase [flavin-containing] A MAOA 0.0143
3939 Amine oxidase [flavin-containing] B MAOB 0.014
118 Organic cation/carnitine transporter 2 SLC22A5 0.0126
6144 Solute carrier family 22 member 2 SLC22A2 0.0125
6145 Solute carrier family 22 member 1 SLC22A1 0.012
6024 Cytochrome P450 1A1 CYP1A1 0.0115
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0092
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0092
6106 Cytochrome P450 2C18 CYP2C18 0.0075
467 Delta-type opioid receptor OPRD1 0.0074
1588 Multidrug resistance protein 1 ABCB1 0.0046
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