DB01040 - Hydroxystilbamidine Isethionate
| Identification | |
|---|---|
| Name | Hydroxystilbamidine Isethionate |
| Accession Number | DB01040 (APRD01024) |
| Type | small molecule |
| Description | Hydroxystilbamidine Isethionate is used in the therapy of some patients with nonprogressive blastomycosis of the skin, and pulmonary or systemic blastomycosis in children, with fewer side effects than amphotericin B. Hydroxystilbamidine Isethionate is also used in pathology for diagnostic purposes. |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 532.588 |
| Groups | approved |
| Monoisotopic Weight | 532.129769894 |
| Pharmacology | |
| Indication | Used in the treatment of nonprogressive blastomycosis of the skin and other mycoses. |
| Mechanism of action | Hydroxystilbamidine isethionate (HSB) acts on extracellular DNA and lysosomes. In Trypanosomes there is extensive and selective binding of HSB to the kinetoplastic DNA. This inhibits cell division and reproduction. In yeast there is evidence of binding to extranuclear DNA causing numerous mutations. HSB is also taken up in the lysosomes and leads to a significant increase in the number of lysosome-like bodies and secretion granules in trypanosomal organisms. HSB may also stabilize lysosomal membranes. HSB has also been found to bind RNA and is a powerful inhibitor of cellular ribonucleases. |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms |
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| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| DNA | |
|---|---|
| Name | DNA |
| Gene Name | Not Available |
| Pharmacological action | yes |
| Actions | other/unknown |
| References |
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| DTHybrid score | Not Available |
Predictions
| Id | Partner name | Gene Name | Score |
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