DB00826 - Natamycin
| Identification | |
|---|---|
| Name | Natamycin |
| Accession Number | DB00826 (APRD01136) |
| Type | small molecule |
| Description | Amphoteric macrolide antifungal antibiotic from Streptomyces natalensis or S. chattanoogensis. It is used for a variety of fungal infections, mainly topically. [PubChem] |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 665.7252 |
| Groups | approved |
| Monoisotopic Weight | 665.304740595 |
| Pharmacology | |
| Indication | For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis. |
| Mechanism of action | LIke other polyene antibiotics, Natamycin inhibits fungal growth by binding to sterols. Specifically, Natamycin binds to ergosterol in the plasma membrane, preventing ergosterol-dependent fusion of vacuoles, as well as membrane fusion and fission. This differs from the mechanism of most other polyene antibiotics, which tend to work by altering fungal membrane permeability instead. |
| Absorption | Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor. |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Ergosterol, Candida albicans | |
|---|---|
| Name | Ergosterol, Candida albicans |
| Gene Name | Not Available |
| Pharmacological action | yes |
| Actions | binder |
| References |
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| DTHybrid score | Not Available |
Predictions
| Id | Partner name | Gene Name | Score |
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