DB00807 - Proparacaine
| Identification | |
|---|---|
| Name | Proparacaine |
| Accession Number | DB00807 (APRD00522) |
| Type | small molecule |
| Description | Proparacaine is a topical anesthetic drug of the amino ester group. It is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. [Wikipedia] |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 294.3892 |
| Groups | approved |
| Monoisotopic Weight | 294.194342708 |
| Pharmacology | |
| Indication | Used as a local (ophthalmic) anesthetic. |
| Mechanism of action | The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. Proparacaine may alter epithelial sodium channels through interaction with channel protein residues. This limitation prevents the fundamental change necessary for the generation of the action potential. |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Plasma |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Sodium channel protein type 10 subunit alpha | |
|---|---|
| Name | Sodium channel protein type 10 subunit alpha |
| Gene Name | SCN10A |
| Pharmacological action | yes |
| Actions | inhibitor |
| References |
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| DTHybrid score | 0.5958 |