DT-Web

DB00707 - Porfimer


Identification
Name Porfimer
Accession Number DB00707 (APRD00078)
Type small molecule
Description The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 1676.0053
Groups approved
Monoisotopic Weight 1674.831531666
Pharmacology
Indication Indicated in the treatment of esophageal cancer.
Mechanism of action Cellular damage caused by porfimer is a consequence of the propagation of radical reactions. Radical initiation may occur after porfimer absorbs light to form a porphyrin excited state. Spin transfer from porfimer to molecular oxygen may then generate singlet oxygen. Subsequent radical reactions can form superoxide and hydroxyl radicals. Tumor death also occurs through ischemic necrosis secondary to vascular occlusion that appears to be partly mediated by thromboxane A2 release.
Absorption Not Available
Protein binding ~90%
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Low-density lipoprotein receptor
Name Low-density lipoprotein receptor
Gene Name LDLR
Pharmacological action unknown
Actions other/unknown
References
  • Korbelik M: Low density lipoprotein receptor pathway in the delivery of Photofrin: how much is it relevant for selective accumulation of the photosensitizer in tumors? J Photochem Photobiol B. 1992 Jan;12(1):107-9. - Pubmed
  • Tsukagoshi S: [Porfimer sodium (Photofrin-II)] Gan To Kagaku Ryoho. 1995 Aug;22(9):1271-8. - Pubmed
  • Maziere JC, Mora L, Biade S, Maziere C, Santus R: [Potentiation of the photocytotoxic effect of photofrin II: synergistic action of verapamil and lovastatin] Bull Acad Natl Med. 1994 Jun;178(6):1177-88; discussion 1188-9. - Pubmed
  • Candide C, Morliere P, Maziere JC, Goldstein S, Santus R, Dubertret L, Reyftmann JP, Polonovski J: In vitro interaction of the photoactive anticancer porphyrin derivative photofrin II with low density lipoprotein, and its delivery to cultured human fibroblasts. FEBS Lett. 1986 Oct 20;207(1):133-8. - Pubmed
  • Maziere JC, Morliere P, Biade S, Santus R: [Antitumor photochemotherapy: biochemical bases, therapeutic uses and perspectives] C R Seances Soc Biol Fil. 1992;186(1-2):88-106. - Pubmed
DTHybrid score 0.5794
High affinity immunoglobulin gamma Fc receptor I
Name High affinity immunoglobulin gamma Fc receptor I
Gene Name FCGR1A
Pharmacological action unknown
Actions antagonist
References
  • Krutmann J, Athar M, Mendel DB, Khan IU, Guyre PM, Mukhtar H, Elmets CA: Inhibition of the high affinity Fc receptor (Fc gamma RI) on human monocytes by porphyrin photosensitization is highly specific and mediated by the generation of superoxide radicals. J Biol Chem. 1989 Jul 5;264(19):11407-13. - Pubmed
DTHybrid score 0.5589

Predictions


Id Partner name Gene Name Score
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.1339
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.1337
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.1332
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.1332
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.1318
3814 Complement C1r subcomponent C1R 0.1309
3817 Complement C1q subcomponent subunit C C1QC 0.124
3815 Complement C1q subcomponent subunit A C1QA 0.124
3816 Complement C1q subcomponent subunit B C1QB 0.1239
2782 Complement C1s subcomponent C1S 0.0708
75 B-lymphocyte antigen CD20 MS4A1 0.0308
793 T-cell surface antigen CD2 CD2 0.0247
724 Interleukin-2 receptor alpha chain IL2RA 0.0181
717 Interleukin-2 receptor subunit beta IL2RB 0.0181
955 Complement C5 C5 0.0162
5898 Complement C3 C3 0.0159
4878 Glycoprotein hormones alpha chain CGA 0.0148
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0148
1072 Granzyme B GZMB 0.0148
4880 Membrane cofactor protein CD46 0.0148
4877 Beta-mannanase man 0.0148
4852 Reticulon-4 receptor RTN4R 0.0148
4850 Beta-2-glycoprotein 1 APOH 0.0148
4856 CD209 antigen CD209 0.0148
4889 Ig epsilon chain C region IGHE 0.0148
4189 Alpha-galactosidase A GLA 0.0148
4869 Major capsid protein A430L 0.0148
4845 ADAM 33 ADAM33 0.0148
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0148
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0148
1354 Beta-glucuronidase GUSB 0.0148
442 Envelope glycoprotein gp41 0.0148
4859 Envelope glycoprotein env 0.0148
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0148
4721 Beta-1,4-mannanase manA 0.0148
3352 Structural polyprotein Not Available 0.0148
3628 Structural polyprotein Not Available 0.0148
4892 Structural polyprotein Not Available 0.0148
844 Epidermal growth factor receptor EGFR 0.0136
93 CAMPATH-1 antigen CD52 0.0136
757 Fusion glycoprotein F0 F 0.0136
4875 Fusion glycoprotein F0 F 0.0136
777 Tumor necrosis factor TNF 0.0133
3837 Cytokine receptor common beta chain CSF2RB 0.0129
4861 Interleukin-6 receptor alpha chain IL6R 0.0129
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0129
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0129
744 Myeloid cell surface antigen CD33 CD33 0.0124
4890 Hemagglutinin HA 0.0116
6566 Hemagglutinin Not Available 0.0116
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0116
1379 Interleukin-12 subunit beta IL12B 0.0116
1184 Interferon beta IFNB1 0.0116
6858 Inactive carboxylesterase 4 CES1P1 0.0116
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0111
852 Heparin cofactor 2 SERPIND1 0.0111
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0111
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0111
2297 Genome polyprotein Not Available 0.0111
2322 Genome polyprotein Not Available 0.0111
2694 Genome polyprotein Not Available 0.0111
2719 Genome polyprotein Not Available 0.0111
2860 Genome polyprotein Not Available 0.0111
2928 Genome polyprotein Not Available 0.0111
3160 Genome polyprotein Not Available 0.0111
3260 Genome polyprotein Not Available 0.0111
4783 Genome polyprotein Not Available 0.0111
5726 Genome polyprotein Not Available 0.0111
5779 Genome polyprotein Not Available 0.0111
5867 Genome polyprotein Not Available 0.0111
6253 Genome polyprotein Not Available 0.0111
6301 Genome polyprotein Not Available 0.0111
6380 Genome polyprotein Not Available 0.0111
6381 Genome polyprotein Not Available 0.0111
6437 Genome polyprotein Not Available 0.0111
6520 Genome polyprotein Not Available 0.0111
6521 Genome polyprotein Not Available 0.0111
6652 Genome polyprotein Not Available 0.0111
6734 Genome polyprotein Not Available 0.0111
6735 Genome polyprotein Not Available 0.0111
6736 Genome polyprotein Not Available 0.0111
6737 Genome polyprotein Not Available 0.0111
6738 Genome polyprotein Not Available 0.0111
6739 Genome polyprotein Not Available 0.0111
6744 Genome polyprotein Not Available 0.0111
6748 Genome polyprotein Not Available 0.0111
6894 Genome polyprotein Not Available 0.0111
6898 Genome polyprotein Not Available 0.0111
1783 Intercellular adhesion molecule 1 ICAM1 0.0108
647 Integrin alpha-4 ITGA4 0.0108
1733 Vitronectin VTN 0.0106
1859 Prostatic acid phosphatase ACPP 0.0103
3140 Hemagglutinin-neuraminidase HN 0.0103
3609 Hemagglutinin-neuraminidase HN 0.0103
3444 Cyanovirin-N Not Available 0.0103
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0103
4787 Envelope glycoprotein gp160 env 0.0101
4820 Envelope glycoprotein gp160 env 0.0101
5727 Envelope glycoprotein gp160 env 0.0101
595 Fibrinogen alpha chain FGA 0.01
5901 T-cell surface glycoprotein CD3 zeta chain CD247 0.0099
5899 T-cell surface glycoprotein CD3 delta chain CD3D 0.0099
5900 T-cell surface glycoprotein CD3 gamma chain CD3G 0.0099
1789 Lymphotoxin-alpha LTA 0.0099
302 T-cell surface glycoprotein CD3 epsilon chain CD3E 0.0099
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0099
4666 Fucose-binding lectin PA-IIL lecB 0.0095
2372 Bifunctional tail protein 9 0.0095
488 Integrin alpha-IIb ITGA2B 0.0091
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.009
3480 Mannan endo-1,4-beta-mannosidase manA 0.0089
958 Insulin-like growth factor 1 receptor IGF1R 0.0089
572 Integrin alpha-L ITGAL 0.0087
64 Neuraminidase NA 0.0086
641 Neuraminidase NA 0.0086
2676 Neuraminidase NA 0.0086
3026 Neuraminidase NA 0.0086
3519 Neuraminidase NA 0.0086
6007 Neuraminidase NA 0.0086
1243 Cathepsin D CTSD 0.0085
309 Antithrombin-III SERPINC1 0.0084
183 Vascular endothelial growth factor A VEGFA 0.0084
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0083
1439 Lactotransferrin LTF 0.0083
2039 Integrin beta-3 ITGB3 0.008
2430 Chondroitinase B cslB 0.0078
6307 Ig gamma-2 chain C region IGHG2 0.0077
2581 Chondroitinase AC cslA 0.0076
6847 Lactase-phlorizin hydrolase LCT 0.0076
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0076
6500 Phospholipase A2 PLA2G1B 0.0073
2207 Rhodopsin RHO 0.0072
4785 Ig gamma-1 chain C region IGHG1 0.0063
4604 Liver carboxylesterase 1 CES1 0.0063
76 Nitric-oxide synthase, brain NOS1 0.0063
952 Dipeptidyl peptidase 4 DPP4 0.0054
3923 Cholinesterase BCHE 0.0052
3811 Cytochrome P450 19A1 CYP19A1 0.0049
20 Prostaglandin G/H synthase 1 PTGS1 0.0047
290 Prostaglandin G/H synthase 2 PTGS2 0.0041
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