DB00646 - Nystatin
| Identification | |
|---|---|
| Name | Nystatin |
| Accession Number | DB00646 (APRD01146) |
| Type | small molecule |
| Description | Nystatin is a polyene antifungal drug to which many molds and yeasts are sensitive, including Candida spp. Nystatin has some toxicity associated with it when given intravenously, but it is not absorbed across intact skin or mucous membranes. It is considered a relatively safe drug for treating oral or gastrointestinal fungal infections. |
| Structure |
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| Categories (*) | |
| Molecular Weight | 926.0949 |
| Groups | approved |
| Monoisotopic Weight | 925.503499979 |
| Pharmacology | |
| Indication | For treatment of cutaneous or mucocutaneous mycotic infections caused by Candida species |
| Mechanism of action | Nystatin exerts its antifungal activity by binding to ergosterol found in fungal cell membranes. Binding to ergosterol causes the formation of pores in the membrane. Potassium and other cellular constituents leak from the pores causing cell death. |
| Absorption | Nystatin is not absorbed from intact skin or mucous membrane. |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms |
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| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions |
|
Targets
| Ergosterol, Candida albicans | |
|---|---|
| Name | Ergosterol, Candida albicans |
| Gene Name | Not Available |
| Pharmacological action | yes |
| Actions | binder |
| References |
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| DTHybrid score | Not Available |
Predictions
| Id | Partner name | Gene Name | Score |
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