DT-Web

DB00634 - Sulfacetamide


Identification
Name Sulfacetamide
Accession Number DB00634 (APRD00452)
Type small molecule
Description An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 214.242
Groups approved
Monoisotopic Weight 214.041212886
Pharmacology
Indication For the treatment of bacterial vaginitis, keratitis, acute conjunctivitis, and blepharitis.
Mechanism of action Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), an essential component for bacterial growth (according to the Woods-Fildes theory). The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Oral LD50 Mouse : 16500 mg/kg. Side effects include moderate to severe erythema (redness) and moderate edema (raised kin), nausea, vomiting, headache, dizziness, and tiredness. Higher exposure causes unconsciousness.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Dihydropteroate synthase
Name Dihydropteroate synthase
Gene Name folP
Pharmacological action yes
Actions inhibitor
References
  • Hevener KE, Zhao W, Ball DM, Babaoglu K, Qi J, White SW, Lee RE: Validation of Molecular Docking Programs for Virtual Screening against Dihydropteroate Synthase. J Chem Inf Model. 2009 Jan 27. - Pubmed
  • BROWN GM: The biosynthesis of folic acid. II. Inhibition by sulfonamides. J Biol Chem. 1962 Feb;237:536-40. - Pubmed
  • Patel OG, Mberu EK, Nzila AM, Macreadie IG: Sulfa drugs strike more than once. Trends Parasitol. 2004 Jan;20(1):1-3. - Pubmed
DTHybrid score 0.8156
Dihydropteroate synthase
Name Dihydropteroate synthase
Gene Name sulI
Pharmacological action yes
Actions inhibitor
References
  • Patel OG, Mberu EK, Nzila AM, Macreadie IG: Sulfa drugs strike more than once. Trends Parasitol. 2004 Jan;20(1):1-3. - Pubmed
DTHybrid score 0.8156
Folic acid synthesis protein FOL1
Name Folic acid synthesis protein FOL1
Gene Name FOL1
Pharmacological action yes
Actions inhibitor
References
  • Patel OG, Mberu EK, Nzila AM, Macreadie IG: Sulfa drugs strike more than once. Trends Parasitol. 2004 Jan;20(1):1-3. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
5359 Dihydropteroate synthase folP 0.8156
587 Serum albumin ALB 0.1048
4757 Cytochrome P450 2C9 CYP2C9 0.0802
6103 Arylamine N-acetyltransferase 1 NAT1 0.0248
4119 Cytochrome P450 2D6 CYP2D6 0.0204
4924 Cytochrome P450 2C8 CYP2C8 0.0182
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0177
6102 Arylamine N-acetyltransferase 2 NAT2 0.0147
4512 Cytochrome P450 3A4 CYP3A4 0.0145
5718 Cytochrome P450 2A6 CYP2A6 0.0136
6013 Cytochrome P450 2E1 CYP2E1 0.0123
6030 Cytochrome P450 2B6 CYP2B6 0.0122
6016 Cytochrome P450 2C19 CYP2C19 0.011
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0101
20 Prostaglandin G/H synthase 1 PTGS1 0.0079
↑