DB00561 - Doxapram
| Identification | |
|---|---|
| Name | Doxapram |
| Accession Number | DB00561 (APRD00935) |
| Type | small molecule |
| Description | A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225) |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 378.5072 |
| Groups | approved |
| Monoisotopic Weight | 378.230728214 |
| Pharmacology | |
| Indication | For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease. |
| Mechanism of action | Doxapram produces respiratory stimulation mediated through the peripheral carotid chemoreceptors. It is thought to stimulate the carotid body by inhibiting certain potassium channels. |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | Intravenous LD50 values in the mouse and rat were approximately 75 mg/kg and in the cat and dog were 40 to 80 mg/kg. Symptoms of overdosage are extensions of the pharmacologic effects of the drug. Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage. |
| Affected organisms |
|
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Potassium channel subfamily K member 3 | |
|---|---|
| Name | Potassium channel subfamily K member 3 |
| Gene Name | KCNK3 |
| Pharmacological action | yes |
| Actions | inhibitor |
| References |
|
| DTHybrid score | 0.8345 |
| Potassium channel subfamily K member 9 | |
| Name | Potassium channel subfamily K member 9 |
| Gene Name | KCNK9 |
| Pharmacological action | yes |
| Actions | inhibitor |
| References |
|
| DTHybrid score | 0.8345 |