DT-Web

DB00505 - Tridihexethyl


Identification
Name Tridihexethyl
Accession Number DB00505 (APRD00286)
Type small molecule
Description Tridihexethyl is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. Tridihexethyl is an antimuscarinic, anticholinergic drug.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 318.5166
Groups approved
Monoisotopic Weight 318.279689779
Pharmacology
Indication Used as an adjunct in the treatment of peptic ulcer disease and in Acquired nystagmus
Mechanism of action Tridihexethyl binds the muscarinic acetylcholine receptor. It may block all three types of muscarinic receptors including M-1 receptors in the CNS and ganglia, M-2 receptors in the heart (vagus) and M-3 receptors at the parasympathetic NEJ system. The muscarinic acetylcholine receptors mediate various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Tridihexethyl inhibits vagally mediated reflexes by antagonizing the action of acetylcholine. This in turn reduces the secretion of gastric acids in the stomach.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Haloperidol The anticholinergic increases the risk of psychosis and tardive dyskinesia
Food Interactions Not Available

Targets


Muscarinic acetylcholine receptor M3
Name Muscarinic acetylcholine receptor M3
Gene Name CHRM3
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5251
Muscarinic acetylcholine receptor M1
Name Muscarinic acetylcholine receptor M1
Gene Name CHRM1
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6588
Muscarinic acetylcholine receptor M2
Name Muscarinic acetylcholine receptor M2
Gene Name CHRM2
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5414

Predictions


Id Partner name Gene Name Score
450 Muscarinic acetylcholine receptor M4 CHRM4 0.2492
274 Muscarinic acetylcholine receptor M5 CHRM5 0.1934
492 Histamine H1 receptor HRH1 0.0869
4119 Cytochrome P450 2D6 CYP2D6 0.0852
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0764
4512 Cytochrome P450 3A4 CYP3A4 0.0703
3923 Cholinesterase BCHE 0.0694
502 5-hydroxytryptamine 2A receptor HTR2A 0.0539
831 D(2) dopamine receptor DRD2 0.0427
1588 Multidrug resistance protein 1 ABCB1 0.0427
556 Alpha-1A adrenergic receptor ADRA1A 0.0425
590 5-hydroxytryptamine 2C receptor HTR2C 0.0384
23 D(1A) dopamine receptor DRD1 0.0335
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0286
6016 Cytochrome P450 2C19 CYP2C19 0.0278
4757 Cytochrome P450 2C9 CYP2C9 0.0266
4200 Cytochrome P450 1A2 CYP1A2 0.0263
824 Sodium-dependent serotonin transporter SLC6A4 0.0258
789 Alpha-1D adrenergic receptor ADRA1D 0.0251
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0245
6013 Cytochrome P450 2E1 CYP2E1 0.0241
632 Alpha-1B adrenergic receptor ADRA1B 0.0233
833 Organic cation/carnitine transporter 1 SLC22A4 0.0218
432 D(4) dopamine receptor DRD4 0.021
4924 Cytochrome P450 2C8 CYP2C8 0.02
6030 Cytochrome P450 2B6 CYP2B6 0.0195
320 5-hydroxytryptamine 1A receptor HTR1A 0.0191
4118 Cytochrome P450 3A5 CYP3A5 0.0189
6145 Solute carrier family 22 member 1 SLC22A1 0.0182
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.018
6144 Solute carrier family 22 member 2 SLC22A2 0.0176
118 Organic cation/carnitine transporter 2 SLC22A5 0.0172
638 D(3) dopamine receptor DRD3 0.0172
318 Alpha-2A adrenergic receptor ADRA2A 0.0161
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0157
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0157
436 5-hydroxytryptamine 2B receptor HTR2B 0.0157
341 5-hydroxytryptamine 3 receptor HTR3A 0.0151
2129 Sucrase-isomaltase, intestinal SI 0.0149
378 Alpha-2C adrenergic receptor ADRA2C 0.0145
629 Alpha-2B adrenergic receptor ADRA2B 0.0144
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0136
124 Histamine H2 receptor HRH2 0.0132
528 5-hydroxytryptamine 1E receptor HTR1E 0.013
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0127
723 Cytosolic phospholipase A2 PLA2G4A 0.0124
1256 5-hydroxytryptamine 6 receptor HTR6 0.0121
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.012
163 D(1B) dopamine receptor DRD5 0.0118
5718 Cytochrome P450 2A6 CYP2A6 0.0116
6024 Cytochrome P450 1A1 CYP1A1 0.0116
716 5-hydroxytryptamine 7 receptor HTR7 0.011
725 5-hydroxytryptamine 1D receptor HTR1D 0.0098
6107 Cytochrome P450 3A7 CYP3A7 0.0097
885 5-hydroxytryptamine 1B receptor HTR1B 0.0096
713 Sodium-dependent dopamine transporter SLC6A3 0.0096
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0093
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0088
1656 CYP2B protein CYP2B 0.0087
474 Acetylcholinesterase ACHE 0.0079
465 Calmodulin CALM1 0.0074
6432 Transporter snf 0.0062
587 Serum albumin ALB 0.0048
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0045
6106 Cytochrome P450 2C18 CYP2C18 0.0044
1360 Sphingomyelin phosphodiesterase SMPD1 0.0043
6147 Solute carrier family 22 member 3 SLC22A3 0.0043
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0043
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0038
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0038
467 Delta-type opioid receptor OPRD1 0.0037
696 Kappa-type opioid receptor OPRK1 0.0037
94 5-hydroxytryptamine 4 receptor HTR4 0.0036
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0036
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0033
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0033
380 Cytochrome P450 17A1 CYP17A1 0.0032
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.003
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.003
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.003
1618 High affinity nerve growth factor receptor NTRK1 0.003
198 Sodium channel protein type 10 subunit alpha SCN10A 0.003
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0029
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0029
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0028
6182 Cytochrome P450 2J2 CYP2J2 0.0028
164 Histamine H4 receptor HRH4 0.0026
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0025
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0023
20 Prostaglandin G/H synthase 1 PTGS1 0.0022
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0022
193 Beta-1 adrenergic receptor ADRB1 0.002
766 Beta-2 adrenergic receptor ADRB2 0.002
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0019
847 Mu-type opioid receptor OPRM1 0.0018
3941 Amine oxidase [flavin-containing] A MAOA 0.0018
1898 Cytochrome P450 1B1 CYP1B1 0.0015
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0015
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